Freezing of Speech Single Questionnaire as a Screening Tool for Cognitive Dysfunction in Patients With Dementia With Lewy Bodies

Abstract

Introduction: Freezing phenomenon is a striking feature of Parkinson's disease. However, it has never been studied in people with dementia with Lewy bodies (DLB). We designed a freezing of speech single questionnaire (FOSSQ) and investigated the frequency and association of freezing of speech (FOS) in patients with DLB and other types of dementia.Methods: This is a retrospective analysis of data from the project of historybased artificial intelligent computerized dementia diagnostic system. We compared the frequencies of FOS among non-demented (ND) participants, patients with Alzheimer's disease (AD), vascular dementia (VaD), and DLB. Further, we explored the association factors of FOS in all the participants.Results: We enrolled 666 individuals with the following disease distribution: 190, ND; 230, AD; 183, VaD; and 63, DLB. Compared to individuals with ND (2.1%), patients with AD (6.1%), or VaD (18.0%), DLB (54.0%) showed a significantly higher frequency of positive FOS (all p < 0.001). The association factors of FOS were older age, more severe dementia, more severe motor dysfunction, fluctuating cognition, visual hallucinations, parkinsonism, rapid eye movement sleep behavior disorder, attention, mental manipulation, and language. Conclusion:Our study showed that the informant-based FOSSQ may be a practical screening tool for discriminating DLB from individuals with ND or other forms of dementia. The FOSSQ can be applied in clinical practice as well as on the artificial intelligent platform.

Synuclein Motor Dysfunction Composite Scale for the Discrimination of Dementia With Lewy Bodies From Alzheimer’s Disease

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Operational Determination of Subjective Cognitive Decline, Mild Cognitive Impairment, and Dementia Using Sum of Boxes of the Clinical Dementia Rating Scale

“…This study is a retrospective analysis of the dementia registry database from the Show Chwan Healthcare System, currently applied in three centers in Taiwan (two in central Taiwan and one in southern Taiwan). In the database, the detailed clinical history of each participant was recorded using a structured questionnaire called the History-Based Artificial Intelligent Clinical Dementia Diagnostic System (HAICDDS), which has been well-validated (Lin et al, 2018 ; Chiu et al, 2019a , b , 2020 ; Tsai and Chiu, 2019 ; Chang et al, 2020 ; Wang et al, 2020 ; Zhu et al, 2020a , b ; Huang et al, 2021 ). In addition, CDR was used for staging dementia, and the daily function was assessed using the Instrumental Activities of Daily Living (IADL) Scale (Lawton and Brody, 1969 ) and Barthel Index (BI) (Mahoney and Barthel, 1965 ).…”

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