Fremkalt respons-undersøkelser i klinisk diagnostikk

Sand, Trond; Kvaløy, Marie Bu; Wader, Tony; Hovdal, Harald

doi:10.4045/tidsskr.12.1176

Cited by 13 publications

(6 citation statements)

References 32 publications

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“…Latency and amplitude are evaluated. VEP provide information about optic neuritis (22). We collected P100 data for each eye and for the 60' and 30' visual angles to obtain data from different macular fibers.…”

Section: Practical Ophthalmological Examinationsmentioning

confidence: 99%

Prospective Assessment of Early Proton Therapy-Induced Optic Neuropathy in Patients With Intracranial, Orbital or Sinonasal Tumors: Impact of A Standardized Ophthalmological Follow Up

Lecornu

Lesueur²,

Salleron³

et al. 2021

Front. Oncol.

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PurposeProton therapy (PT) can be a good option to achieve tumor control while reducing the probability of radiation induced toxicities compared to X-ray-based radiotherapy. However, there are still uncertainties about the effects of PT on the organs in direct contact with the irradiated volume. The aim of this prospective series was to report 6-month follow-up of clinical and functional optic neuropathy rates of patients treated by proton therapy using a standardized comprehensive optic examination.Methods and MaterialsStandardized ophthalmological examinations were performed to analyze subclinical anomalies in a systematic way before treatment and 6 months after the end of proton therapy with: Automatic visual field, Visual evoked potential (VEP) and optic coherence of tomography (OCT).ResultsFrom October 2018 to July 2020 we analyzed 81 eyes. No significant differences were found in the analysis of the clinical examination of visual functions by the radiation oncologist. However, considering VEP, the impairment was statistically significant for both fibers explored at 30’angle (p:0.007) and 60’angle (p <0.001). In patients with toxicity, the distance of the target volume from the optical pathways was more important with a p-value for 30’VEP at 0.035 and for 60’VEP at 0.039.ConclusionsThese results confirm uncertainties concerning relative biological effectiveness of proton therapy, linear energy transfer appears to be more inhomogeneous especially in areas close to the target volumes. The follow-up of patients after proton therapy is not an easy process to set up but it is necessary to improve our knowledges about the biological effects of proton therapy in real life. Our study which will continue during the coming years, suggests that follow-up with in-depth examinations such as VEP as a biomarker could improve the detection of early abnormalities.

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Section: Practical Ophthalmological Examinationsmentioning

confidence: 99%

Prospective Assessment of Early Proton Therapy-Induced Optic Neuropathy in Patients With Intracranial, Orbital or Sinonasal Tumors: Impact of A Standardized Ophthalmological Follow Up

Lecornu

Lesueur²,

Salleron³

et al. 2021

Front. Oncol.

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“…According Electrophysiological measures have many bene ts in SCI clinical trials (Sand et al 2013). They are largely objective, independent of patient cooperation, and unbiased, as the results do not depend on subjective patient responses.…”

Section: Resultsmentioning

confidence: 99%

Intelligent Integration of Assessment Tools for Specialized Prognosis in Spinal Cord Injuries: A scoping review

Chrysanthakopoulou,

Koutsojannis,

Matzaroglou

et al. 2023

Preprint

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Spinal cord injury is a life-threatening condition resulting from spinal cord trauma, leading to paralysis, loss of sensation, bowel and bladder control. Accurate assessment tools are crucial for diagnosing and treating spinal cord injuries, and various scales have been developed for this purpose. Additionally, electrophysiological measures, including somatosensory evoked potentials, motor evoked potentials, and nerve conduction studies, can aid in patient stratification. Recent developments in spinal cord injury assessment have shown promise, particularly with the use of advanced imaging techniques and artificial intelligence. Neuroimaging and molecular biomarkers combined with electrophysiological measures, promise to predict outcomes and guide treatment decisions. Machine learning and Artificial intelligence have revolutionized the healthcare industry, including the field of spinal cord injuries, as they can facilitate personalized medicine by accurately predicting. Challenges remain in validating machine learning models and ensuring they are safe and effective for clinical use. Quality data and expertise are crucial for accurately interpreting and applying machine learning results in spinal cord injury management. Moreover, due to artificial intelligence entering healthcare to assist in processing data, electrophysiology can eventually meet the high-quality information it can provide, as it is easier to analyze data recordings from somatosensory evoked potentials and other electrophysiologic measures. Summing up, the integration of advanced imaging techniques, biomarkers, and machine learning leading to maximizing the use and importance of electrophysiology as far as the information it can reveal, has the potential to revolutionize the diagnosis, prognosis, and treatment of spinal cord injuries, leading to improved patient outcomes and personalized care.

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“…If this is the case, then ABR testing might be useful for diagnosis and to monitor the progression of disease, particularly in children with a mild presentation (Yalcinkaya et al, 2005). In a similar manner, increased latency and decreased amplitude of ABR peaks have been used as criteria in the diagnosis of multiple sclerosis (Peyvandi et al, 2010; Sand et al, 2013). ABR testing is already used in universal newborn hearing screening (Mason and Herrmann, 1998) and is a rapid, inexpensive and non-invasive test.…”

Section: Discussionmentioning

confidence: 99%

A new mouse model of Canavan leukodystrophy displays hearing impairment due to central nervous system dysmyelination

Carpinelli

Voss

Manning

et al. 2014

Disease Models &Amp; Mechanisms

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Canavan disease is a leukodystrophy caused by mutations in the ASPA gene. This gene encodes the enzyme that converts N-acetylaspartate into acetate and aspartic acid. In Canavan disease, spongiform encephalopathy of the brain causes progressive mental retardation, motor deficit and death. We have isolated a mouse with a novel ethylnitrosourea-induced mutation in Aspa. This mutant, named deaf14, carries a c.516T>A mutation that is predicted to cause a p.Y172X protein truncation. No full-length ASPA protein is produced in deaf14 brain and there is extensive spongy degeneration. Interestingly, we found that deaf14 mice have an attenuated startle in response to loud noise. The first auditory brainstem response peak has normal latency and amplitude but peaks II, III, IV and V have increased latency and decreased amplitude in deaf14 mice. Our work reveals a hitherto unappreciated pathology in a mouse model of Canavan disease, implying that auditory brainstem response testing could be used in diagnosis and to monitor the progression of this disease.

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Fremkalt respons-undersøkelser i klinisk diagnostikk

Cited by 13 publications

References 32 publications

Prospective Assessment of Early Proton Therapy-Induced Optic Neuropathy in Patients With Intracranial, Orbital or Sinonasal Tumors: Impact of A Standardized Ophthalmological Follow Up

Prospective Assessment of Early Proton Therapy-Induced Optic Neuropathy in Patients With Intracranial, Orbital or Sinonasal Tumors: Impact of A Standardized Ophthalmological Follow Up

Intelligent Integration of Assessment Tools for Specialized Prognosis in Spinal Cord Injuries: A scoping review

A new mouse model of Canavan leukodystrophy displays hearing impairment due to central nervous system dysmyelination

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