French Adaptation of the Vascular Cognitive Impairment Harmonization Standards: The GRECOG-VASC Study

Godefroy, Olivier; Leclercq, Claire; Roussel, Martine; Moroni, Christine; Quaglino, Véronique; Beaunieux, Hélène; Tallia, Hervé; Nédélec-Ciceri, Claudine; Bonnin, Camille; Thomas‐Antérion, Catherine; Varvat, Jérôme; Aboulafia-Brakha, Tatiana; Assal, Frédéric

doi:10.1111/j.1747-4949.2012.00794.x

Cited by 36 publications

(25 citation statements)

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“…The lack of satisfactory criteria for VCI diagnosis and its preventable nature urged the establishment of NINDS-CSN neuropsychological battery [ 7 ]. International effort has been made by validation studies from France [ 9 ], Hong Kong [ 8 ], and Singapore [ 10 ]. Our study was consistent with previous studies, also showing good validity and reliability of the protocols for diagnosing VCI.…”

Section: Discussionmentioning

confidence: 99%

“…A similar conclusion was drawn by researchers in the Singapore [ 10 ] and our previous Hong Kong [ 8 ] validation studies. The French study [ 9 ] (ClinicalTrials.gov ID: NCT01339195) was supposed to end in August 2013, yet no results have been published so far.…”

Section: Discussionmentioning

confidence: 99%

“…Because there are language and culture differences across countries, validation of the NINDS-CSN neuropsychological protocols is critical for the implementation of VCI diagnosis. Currently, Korean [ 3 ], Hong Kong [ 8 ], France [ 9 ] and Singapore [ 10 ] have validated these protocols in stroke or transient ischemic attack patients. However, there is no validation study in the population of mainland China, where stroke and dementia burden are one of the highest countries worldwide [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

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Validation of NINDS-CSN neuropsychological battery for vascular cognitive impairment in Chinese stroke patients

Chen

Wong

et al. 2015

BMC Neurol

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BackgroundThe NINDS-Canadian Stroke Network (NINDS-CSN) recommended a neuropsychological battery of three protocols to diagnose vascular cognitive impairment (VCI), however, due to culture and language differences, the battery cannot be directly used in China. Validation of the battery in mandarin Chinese is lacking. Our study investigated the reliability and validity of the adapted Chinese versions of the battery in stroke patients with high probability of VCI.MethodsFifty mild stroke patients (median of National Institute of Health Stroke Scale [NIHSS] score, 2) and 50 stroke-free normal controls were recruited. All subjects’ demographics, clinical history, and stroke severity were recorded. The NINDS-CSN neuropsychological protocols were adapted into the Chinese versions. External validity, defined as the ability of the protocol summary scores to differentiate stroke patients from controls, was determined using the area under the curve (AUC) of the receiver operating characteristics curve. We also evaluated internal consistency and intra-rater reliability.ResultsStroke patients performed significantly poorer than controls on all three protocols (F statistics between 24.9 and 31.4, P < 0.001). External validity evaluated by AUCs was 0.88 (95% confidence interval [CI], 0.81-0.95), 0.88 (95% CI, 0.81-0.94), and 0.86 (95% CI, 0.79-0.94) for the 60-min, 30-min and 5-min protocols, respectively. Cronbach’s alpha of the cognitive tests was 0.87 for all subjects. Intra-rater reliability was acceptable with intraclass correlation coefficients 0.90, 0.83 and 0.75 for the 60-min, 30-min and 5-min protocols, respectively.ConclusionsThe adapted Chinese versions of three NINDS-CSN neuropsychological protocols were valid and reliable for assessing VCI in Chinese patients with mild stroke.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Validation of NINDS-CSN neuropsychological battery for vascular cognitive impairment in Chinese stroke patients

Chen

Wong

et al. 2015

BMC Neurol

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“…(2004; 2007) [32], [33]Groupe de Réflexion pour l'Evaluation COGnitive VASCulaire study (GRECOG-VASC)§France2010–20153606m6 mo6 moVASCOGGodefroy et al. (2012) [34]Helsinki Stroke Aging Memory (SAM)Finland1993–20154863m, 15m, 21y3 moInitialDSMJokinen et al. (2015) [35]; Oksala et al(2009) [36]Maastricht Cognitive Disorders After Stroke (CODAS)Netherlands2000–20031941m, 6m, 1y, 2y1 mo, 6 mo, 1 y, 2 yNoDSM-III, DSM-III-R, DSM-IV, ICD-10, NINDS-AIREN, ADDTCRasquin et al.…”

Section: Methodsmentioning

confidence: 99%

STROKOG (stroke and cognition consortium): An international consortium to examine the epidemiology, diagnosis, and treatment of neurocognitive disorders in relation to cerebrovascular disease

Sachdev

Crawford

et al. 2016

Alz & Dem Diag Ass & Dis Mo

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IntroductionThe Stroke and Cognition consortium (STROKOG) aims to facilitate a better understanding of the determinants of vascular contributions to cognitive disorders and help improve the diagnosis and treatment of vascular cognitive disorders (VCD).MethodsLongitudinal studies with ≥75 participants who had suffered or were at risk of stroke or TIA and which evaluated cognitive function were invited to join STROKOG. The consortium will facilitate projects investigating rates and patterns of cognitive decline, risk factors for VCD, and biomarkers of vascular dementia.ResultsCurrently, STROKOG includes 25 (21 published) studies, with 12,092 participants from five continents. The duration of follow-up ranges from 3 months to 21 years.DiscussionAlthough data harmonization will be a key challenge, STROKOG is in a unique position to reuse and combine international cohort data and fully explore patient level characteristics and outcomes. STROKOG could potentially transform our understanding of VCD and have a worldwide impact on promoting better vascular cognitive outcomes.

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“…Our comparison with the HSP indicated that it does not underestimate the prevalence of cognitive dysexecutive disorder when it is due to arterial infarct or hemorrhage. From a clinical perspective, our study indicates that the assessment of executive functions in stroke should include both a validated inventory of behavioral dysexecutive syndrome and cognitive tests [ 41 ]. In patients with infarct and cerebral hemorrhage, initial assessment may be based on executive function tests from the HSP.…”

Section: Discussionmentioning

confidence: 99%

The Behavioral and Cognitive Executive Disorders of Stroke: The GREFEX Study

Roussel¹,

Martinaud²,

Hénon³

et al. 2016

PLoS ONE

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BackgroundMany studies have highlighted the high prevalence of executive disorders in stroke. However, major uncertainties remain due to use of variable and non-validated methods. The objectives of this study were: 1) to characterize the executive disorder profile in stroke using a standardized battery, validated diagnosis criteria of executive disorders and validated framework for the interpretation of neuropsychological data and 2) examine the sensitivity of the harmonization standards protocol proposed by the National Institute of Neurological Disorders and Stroke and Canadian Stroke Network (NINDS-CSN) for the diagnosis of Vascular Cognitive Impairment.Methods237 patients (infarct: 57; cerebral hemorrhage: 54; ruptured aneurysm of the anterior communicating artery (ACoA): 80; cerebral venous thrombosis (CVT): 46) were examined by using the GREFEX battery. The patients’ test results were interpreted with a validated framework derived from normative data from 780 controls.ResultsDysexecutive syndrome was observed in 88 (55.7%; 95%CI: 48–63.4) out of the 156 patients with full cognitive and behavioral data: 40 (45.5%) had combined behavioral and cognitive syndromes, 29 (33%) had a behavioral disorder alone and 19 (21.6%) had a cognitive syndrome alone. The dysexecutive profile was characterized by prominent impairments of initiation and generation in the cognitive domain and by hypoactivity with disinterest and anticipation loss in the behavioral domain. Cognitive impairment was more frequent (p = 0.014) in hemorrhage and behavioral disorders were more frequent (p = 0.004) in infarct and hemorrhage. The harmonization standards protocol underestimated (p = 0.007) executive disorders in CVT or ACoA.ConclusionsThis profile of executive disorders implies that the assessment should include both cognitive tests and a validated inventory for behavioral dysexecutive syndrome. Initial assessment may be performed with a short cognitive battery, such as the harmonization standards protocol. However, administration of a full cognitive battery is required in selected patients.

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French Adaptation of the Vascular Cognitive Impairment Harmonization Standards: The GRECOG-VASC Study

Cited by 36 publications

References 5 publications

Validation of NINDS-CSN neuropsychological battery for vascular cognitive impairment in Chinese stroke patients

Validation of NINDS-CSN neuropsychological battery for vascular cognitive impairment in Chinese stroke patients

STROKOG (stroke and cognition consortium): An international consortium to examine the epidemiology, diagnosis, and treatment of neurocognitive disorders in relation to cerebrovascular disease

The Behavioral and Cognitive Executive Disorders of Stroke: The GREFEX Study

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