“…37 However, based on patient characteristics, similar to those of patients with COPD, exercise training has emerged as a key component for CR in patients with CHF. 34,35 The systemic consequences of COPD and CHF show considerable similarity, including skeletal muscle dysfunction, mood disturbances, osteoporosis, hormonal alterations, and anemia. 34 Factors such as hypoxemia, disuse, aging, nutritional depletion, medication use, systemic inflammation, and smoking can contribute to skeletal muscle dysfunction, early onset of peripheral muscle fatigue, and impaired endurance performance.…”