Fréquence des signes de gravité du paludisme chez l’enfant à Dakar

Camara, B.; Diagne-Guèye, N.R.; Faye, P.M.; Fall, Lamine; Niang, Dibor; Mc, Ba; Sow, H.

doi:10.1016/j.arcped.2010.03.013

Cited by 5 publications

(7 citation statements)

References 4 publications

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“…The association between cerebral malaria and the death of children affected by severe malaria as registered in our distribution coinside with results from previous research carried out in Africa [ 6 , 18 , 30 , 31 ]. Litterature revue shows that the gravity of cerebral malaria could be explained by the sequestration of invaded red blood cell in a tissus, causing vital dysfonction in the concerned organ for exemple the production of cytokines (TNF, IFN) which may cause the release of carbon monoxyde [ 32 - 35 ].…”

Section: Discussionsupporting

confidence: 91%

Severe malaria and death risk factors among children under 5 years at Jason Sendwe Hospital in Democratic Republic of Congo

Mutombo¹,

Mukuku²,

Tshibanda³

et al. 2018

Pan Afr Med J

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IntroductionMalaria is still a major public health concern in the Democratic Republic of Congo. Its morbidity and mortality challenge the actual strategies of the fight agains malaria. This study was aimed to describe the epidemiology, the clinical caracteristics and the risk factors of death associated to severe malaria in the pediatric population under 5 years at Sendwe Hospital of Lubumbashi.MethodsThis analytical retrospective study was conducted in Lubumbashi, in the province of Haut-Katanga. All patients under 5 years hospitalized for severe malaria were registered from January 2014 to December 2016.ResultsAmong the 3,092 patients hospitalised during our study period, 452 (14.6%) were admitted for severe malaria. The average age was 27.04 months, the male sex was the most affected (53.54% with the sex-ratio 1.15). The most frequent forms of gravity noticed were cerebral malaria (48.23%) and severe anemia (46.90%). Death was noted in the evolution in 28.32%. Repeated convulsion (OR = 2.27; 95% CI: 1.47-3.48), coma (OR = 3.55; 95% CI: 2.19-5.74) and severe acute malnutrition (OR = 3.32; 95% CI: 1.56-7.06) were asscociated with a high risk of death.ConclusionThis research shows that severe malaria is still an important cause of morbidity and mortality among young children in Lubumbashi. Neurologic and anemic forms are the most frequent. The predictive signs of death are: repeated convulsions, coma and severe acute malnutrition.

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Section: Discussionsupporting

confidence: 91%

Severe malaria and death risk factors among children under 5 years at Jason Sendwe Hospital in Democratic Republic of Congo

Mutombo¹,

Mukuku²,

Tshibanda³

et al. 2018

Pan Afr Med J

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“…This rate is lower than those observed in Togo and Benin respectively, of about 28% and 30.76% [6,20]. Our results are within the range estimated by the WHO; reporting the probability of retaining neurological sequelae between 5% and 30% in children who survive neuromalaria [23,24]. Regarding the origin of the sequelae in this study, neuromalaria is the first provider of neurological sequelae with 42.85% (n=9) of cases; followed by neuromeningeal tuberculosis and sepsis with 14.28% (n=3) for each pathology.…”

Section: About the After-effectssupporting

confidence: 68%

“…The high mortality in Africa is attributable, among other things, to the depth of the coma, late admission due to the delay in consultation, the predominance of children under 24 months of age, and the quality of management, sometimes due to the obsolescence of the technical facilities of emergency departments and intensive care units [1]. In addition to the risk of death, children are also likely to have neurological sequelae [23,24]. The problems posed by this condition are difficult and require a good understanding of the semiology and a real diagnostic and therapeutic strategy for their solution [25].…”

Section: Introductionmentioning

confidence: 99%

Untitled

2022

JPNB

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IntroductionNon-traumatic coma is the most common pediatric medical emergency. Their therapeutic and evolutionary profile remains controversial in resource-limited countries. We report our experience with 370 children. ObjectiveTo evaluate the management and evolution of nontraumatic comas in the intensive care unit of the Pediatric Hospital Complex of Bangui (CHUPB). Materials and methods: This was a descriptive and analytical cross-sectional study conducted between January 1 and June 31, 2021 at the CHUPB. Children aged 1 month to 15 years, admitted to the intensive care unit of CHUPB with a Glasgow score less than or equal to 8 in a trauma-free setting were included. Data were entered and analyzed using SPSS 20.0 statistical software. The statistical test used was Pearson's chi-square. Any p-value <0.05 was considered statistically significant. ResultDuring the study period, 370 children were admitted to the intensive care unit of CHUPB for non-traumatic coma. The sex ratio was 1.35 and the mean age was 35.95±27.21 months. Neuromalaria (29.72%), meningitis-meningoencephalitis-encephalitis (30%), septic states (19.72%) and acidotic coma (5.40%) were the main etiologies. The children had received emergency drug treatment based on anticonvulsants in 59.18% of cases, antipyretics in 91.35% of cases and dopamine 18.1% of cases. Drug treatment was adapted to the etiology in 44.60% of cases and probabilistic in 55.40% (n=205) of cases. Neurological sequelae were noted in 8.93% of cases and death in 36.48%, 57.77% of which occurred within the first 48 hours. ConclusionInfectious diseases are the predominant cause of biologically documented non-traumatic comas and are also the cause of non-documented clinical situations. This reality has induced the use of anti-infectives beyond the rational with an outcome marked by high mortality and sequelae. The transformation of these outcomes requires the reinforcement of the technical platform of the CHUPB.

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“…In Benin, in the study of Lalya et al, fewer children had impaired consciousness or 18 children out of 54 (33.3%) [11]. This could be related to the uremic syndrome that can increase the rate of patients with consciousness disorder, since uremia has its proper neurological manifestations, such as impaired concentration, decreased cognitive function, seizures, mental clouding or coma [9].…”

Section: Commentmentioning

confidence: 99%

“…In Senegal, studies on severe post malaria ARF (IRA-PG) included only children, and mainly focused on the prevalence [9,10]. With this in mind, we therefore undertook this work in order to determine the epidemiological, clinical, therapeutic and evolutionary profile of acute renal failure following severe malaria (IRA-PG) in the hospital environment.…”

Section: Introductionmentioning

confidence: 99%