Frequência do Papilomavírus Humano na placenta, no colostro e no sangue do cordão umbilical

Teixeira, Lisiane Ortiz; Amaral, Suélen Cavalheiro; Finger‐Jardim, Fabiana; Hora, Vanusa Pousada da; Gonçalves, Carla Vitola; Soares, Marcelo A.; Martínez, Ana Maria Barral de

doi:10.1590/so100-720320150005293

Cited by 8 publications

(6 citation statements)

References 19 publications

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“…Vertical HPV transmission from mother to fetus has been also docu mented [25,26]. HPV DNA has been found in the oral cavity of newborns [26], breast milk [27], amniotic fluid, placenta, and umbilical cord blood [28]. HPV causing laryngeal papillomatosis can be transmitted to the new borns during birth and in utero; it was also found in chil dren born by caesarean section [22,23].…”

Section: Hpv Transmission Routesmentioning

confidence: 99%

Carcinogenesis Associated with Human Papillomavirus Infection. Mechanisms and Potential for Immunotherapy

Shabaeva

Runov

Лебедева

et al. 2019

Biochemistry Moscow

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Human papillomavirus (HPV) infection is responsible for approximately 5% of all cancers and is associated with 30% of all pathogen related cancers. Cervical cancer is the third most common cancer in women worldwide; about 70% of cervical cancer cases are caused by the high risk HPVs (HR HPVs) of genotypes 16 and 18. HPV infection occurs mainly through sexual contact; however, viral transmission via horizontal and vertical pathways is also possible. After HPV infec tion of basal keratinocytes or ecto endocervical transition zone cells, viral DNA persists in the episomal form. In most cases, infected cells are eliminated by the immune system. Occasionally, elimination fails, and HPV infection becomes chronic. Replication of HPVs in dividing epithelial cells is accompanied by increased expression of the E6 and E7 oncoproteins. These oncoproteins are responsible for genomic instability, disruption of the cell cycle, cell proliferation, immortalization, and malignant transformation of HPV infected cells. Besides, E6 and E7 oncoproteins induce immunosuppression, pre venting the detection of HPV infected and transformed cells by the immune system. HPV integration into the genome of the host cell leads to the upregulation of E6 and E7 expression and contributes to HPV associated malignization. Prophylactic HPV vaccines can prevent over 80% of HPV associated anogenital cancers. The vaccine elicits immune response that prevents initial infection with a given HPV type but does not eliminate persistent virus once infection has occurred and does not prevent development of the HPV associated neoplasias, which necessitates the development of ther apeutic vaccines to treat chronic HPV infections and HPV associated malignancies.

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Section: Hpv Transmission Routesmentioning

confidence: 99%

Carcinogenesis Associated with Human Papillomavirus Infection. Mechanisms and Potential for Immunotherapy

Shabaeva

Runov

Лебедева

et al. 2019

Biochemistry Moscow

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“…The low oncogenic risk genotype tracked was the HPV-6 (60%), and the high oncogenic risk was the HPV-16 and the HPV-18 (20% each). 8 High-risk HPV virus infection is an indispensable condition, although not sufficient, to the development of cervical cancer.…”

Section: Introductionmentioning

confidence: 99%

Knowledge of Pregnant Adolescents about Human Papillomavirus

Tanaka

Kamizaki

Quintana

et al. 2019

Rev Bras Ginecol Obstet

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Objective To evaluate the level of information possessed by pregnant adolescents regarding the human papillomavirus (HPV). Methods Descriptive study developed in the adolescent prenatal outpatient clinic of a tertiary hospital from the state of São Paulo, Brazil. Data were collected between June and December 2017 following approval from the ethics and research committee (CAAE: 1.887.892/2017). Pregnant adolescents, ≤18 years old, who attended the abovementioned outpatient section, composed the sample. Those diagnosed with a psychiatric disorder and those with hearing or cognitive disabilities were excluded. After acceptance to participate in the present study, the pregnant adolescents signed an Informed Consent Form. Regarding the statistical analysis, the chi-squared test and the Fisher exact test were used. Results Regarding the knowledge about HPV, 123 (80.92%) of the participants had already heard about the subject; for 77 (50.66%), their schools had been the source of the information; 101 (66.45%) did not know how they could be infected by the virus. Age variation did not influence their knowledge on how to prevent themselves from HPV (p = 0.2562). The variable vaccine is associated with HPV prevention (p < 0.0001). Conclusion The pregnant adolescents composing the sample have shown to have knowledge about HPV. However, they do not prevent themselves from it appropriately, given that little more than half of the sample was vaccinated, had not reported an understanding that the use of preservatives and vaccination are effective means of prevention, and did not correlate HPV with uterine cervical cancer.

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“…O Papilomavírus Humano (HPV) é um vírus responsável por infectar células epiteliais e desenvolver verrugas genitais e cânceres de útero, pênis e ânus. Estima-se que haja em torno de 120 tipos de vírus, e destes, 36 podem infectar o sistema genital masculino e feminino (TEIXEIRA et al, 2015).…”

Section: Introductionunclassified

“…Observa-se, pois, que a ausência de conhecimentos sobre as formas de transmissão do HPV pode mascarar uma infecção que se manifesta de modo latente, sem que haja o desenvolvimento das lesões, prejudicando o diagnóstico precoce (COSTA; GOLDENBERG, 2013;TEIXEIRA et al, 2015). A compreensão sobre a importância da infecção por HPV e os riscos de desenvolvimento de lesões cancerígenas em adolescentes ainda é pequena, sobretudo entre os próprios adolescentes.…”

Section: Introductionunclassified

Estudos Multidisciplinares Sobre Saúde Da Criança E Do Adolescente

SOUSA¹,

BARBOSA²,

MACÊDO³

et al. 2023

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A primeira edição do Congresso Brasileiro de Saúde da Criança e do Adolescente foi realizado de forma remota, nos dias 16, 17 e 18 de dezembro de 2022, sendo promovido pelo Instituto Academic (CNPJ: 42.698.982/0001-87). O evento contou com a participação de vários palestrantes renomados que discutiram temáticas relevantes sobre o cuidado à saúde da criança e adolescente. O objetivo do evento foi de promover a educação, capacitação, treinamento e atualização multidisciplinar na área da saúde da criança e do adolescente, sendo destinado a discentes, docentes, profissionais de saúde e demais interessados pela discussão da temática. O e-book é composto por 50 capítulos que servem de base para a construção do conhecimento baseado em evidências, servindo de base para reflexão, discussão e embasamento teórico para a construção de outros estudos sobre a área.

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Frequência do Papilomavírus Humano na placenta, no colostro e no sangue do cordão umbilical

Abstract: These results suggest that HPV can infect the placenta, the colostrum and the umbilical cord blood.

Cited by 8 publications

References 19 publications

Carcinogenesis Associated with Human Papillomavirus Infection. Mechanisms and Potential for Immunotherapy

Carcinogenesis Associated with Human Papillomavirus Infection. Mechanisms and Potential for Immunotherapy

Knowledge of Pregnant Adolescents about Human Papillomavirus

Estudos Multidisciplinares Sobre Saúde Da Criança E Do Adolescente

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