Frequencies and Association of CYP3A5 Polymorphism With Tacrolimus Concentration Among Renal Transplant Recipients in Vietnam

Pharmacogenomic Analysis of CYP3A5*3 and Tacrolimus Trough Concentrations in Vietnamese Renal Transplant Outcomes

“…Therefore, Tac metabolism in renal transplant recipients carrying CYP3A5*3*3 is much slower than that of CYP3A5 expressors, which is supported by a number of studies and meta-analyses such as the finding of Chauhan et al 16 Our findings are consistent with those of previous studies. 6 , 16 , 17 In addition to CYP3A5, the post-operative day (POD) serves as a crucial covariate included in four out of the five examined models. However, there is some inconsistency in the effect of POD on tacrolimus clearance among these models.…”

“…Therefore, Tac metabolism in renal transplant recipients carrying CYP3A5*3*3 is much slower than that of CYP3A5 expressors, which is supported by a number of studies and meta-analyses such as the finding of Chauhan et al 16 Our findings are consistent with those of previous studies. 6,16,17 In addition to CYP3A5, the post-operative day (POD) serves as a crucial covariate included in Numerous studies have demonstrated the significance of hematocrit (HCT) in influencing population pharmacokinetic (PopPK) models in kidney transplant patients. Specifically, tacrolimus has a strong binding affinity to erythrocytes in plasma, leading to higher HCT levels indicating an increased fraction of tacrolimus bound to erythrocytes and a decreased fraction in the plasma.…”

“…[2][3][4] Some studies conducted in Vietnam have also examined the high prevalence of the *3 allele of the CYP3A5 gene and its impact on Tacrolimus trough concentration. 5,6 However, a precise formula to accurately quantify the influence of CYP3A5 genotype on the pharmacokinetic data of Vietnamese patients for determining the Tacrolimus dose has not yet been identified.…”