Frequencies and specificities of red cell alloantibodies in the Southern Thai population

Promwong, Charuporn; Siammai, Santi; Hassarin, Sarunya; Buakaew, Jarin; Yeela, T; Soisangwan, Patravee; Roxby, David

doi:10.4103/0973-6247.106718

Cited by 30 publications

(27 citation statements)

References 8 publications

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“…These patients were children: pregnancy‐associated exposure was not relevant for this group. Anti‐E and anti‐Mi a are identified frequently in donors who have not received transfusions or have never been pregnant, and these antibodies may also be induced by environmental stimuli . However, other than these two so‐called naturally occurring antibodies, immune RBC antibodies were not detected in the antigen‐matched RBC group in the current cohort within the observation period of 10 years.…”

Section: Discussionmentioning

confidence: 66%

The prevalence, alloimmunization risk factors, antigenic exposure, and evaluation of antigen‐matched red blood cells for thalassemia transfusions: a 10‐year experience at a tertiary care hospital

et al. 2018

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The prevalence, alloimmunization risk factors, antigenic exposure, and evaluation of antigen-matched red blood cells for thalassemia transfusions: a 10-year experience at a tertiary care hospital BACKGROUND: Hemoglobin E-β 0 thalassemia and homozygous β 0 -thalassemia are the most common chronic transfusion-dependent thalassemias in Thailand. Patients with these conditions can experience clinical complications such as RBC alloimmunization. In this study we aimed to determine the prevalence, alloimmunization risk factors, antigenic exposure, and evaluation of antigen-(C, c, E, e, Mi a ) matched RBC transfusion. STUDY DESIGN AND METHODS: Thalassemia patients were recruited from a tertiary care hospital for 10 years from 2008 to 2017. The medical records of transfusion history were reviewed for red cell phenotype both of patients and donors, number of units transfused, and type of alloantibodies. RESULTS: A total of 383 thalassemia patients were identified (178 males and 205 females). The frequency of RBC alloantibodies was 19.3%. Some patients tested positive for more than one antibody type. Autoantibodies were detected in nine individuals. Anti-E (49 [39.5%]), anti-Mi a (24 [19.4%]), and anti-c (19 [15.3%]) were the most common antibodies detected. A high rate of alloimmunization was found in splenectomized patients. Risk of alloimmunization increased when more total units of blood had been transfused. A trend toward low alloimmunization rates was noted in the antigen-matched RBC group, where 3.5% (5/143) of patients were alloimmunized. Anti-E and anti-Mi a , which may be naturally occurring, were identified in this group.CONCLUSION: Thai patients are more prone to develop antibodies against the Rh and Mi a than to the Kell blood group antigens.

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Section: Discussionmentioning

confidence: 66%

The prevalence, alloimmunization risk factors, antigenic exposure, and evaluation of antigen‐matched red blood cells for thalassemia transfusions: a 10‐year experience at a tertiary care hospital

et al. 2018

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“…The prevalence of red cell alloand autoantibodies has been reported in several study populations including hospital based patients, transfusion dependent patients with chronic haematological disorders, pregnant females and blood donors, and the incidence of alloantibodies detected worldwide is 0.2%-0.9% in healthy blood donors, 2%-9% in patients with a history of blood transfusion, 9%-30% among chronic transfusion dependant patients, 0.5%-1.9% among antenatal women and 0.5%-1% of red cell autoantibodies among transfused patients [8][9][10][11][12][13][14].…”

Section: Discussionmentioning

confidence: 99%

Erythrocyte Alloimmunization and Autoimmunization among Blood Donors and Recipients visiting a Tertiary Care Hospital

Kaur

Bains

Kandwal

et al. 2017

JCDR

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Introduction: The ultimate aim of pretransfusion testing is the acceptable survival of donor red cells in recipient's body and antibody detection plays a critical role in achieving the same. The cornerstone of antibody detection method is detecting an unexpected antibody as against the expected antibodies of ABO blood group system. Autoantibodies can also interfere with the detection of clinically significant alloantibodies. Aim:To study the frequency of alloantibodies and autoantibodies in the healthy blood donors and patient population visiting our hospital. Materials and Methods:The Column Agglutination Technology (CAT) was used for ABO RhD blood grouping, Direct Antiglobulin Test (DAT), Autocontrol (AC), Indirect Antiglobulin Test (IAT) and red cell antibody screening and the unexpected reactions in any of these tests were recorded for further evaluation. Ethylene Diamine Tetra Acetic Acid (EDTA) blood samples were used for all these tests for both blood donors and admitted patients. The CAT was exercised for the blood grouping (using ABDReverse Diluent cassettes) and antibody screening (using 0. Results: Among all blood donors (n=6350), seven (0.11%) donors had showed unexpected reaction. Of these, four had positive antibody screen (three having naturally occuring antibodies 2=anti-M, 1=anti-Le a and 1=inconclusive) and the other three had positive DAT. Of all the patient samples (n=6136) screened for irregular red cell antibodies, four (0.06%) patients were found to have unexpected reaction revealing one (0.02%) with anti-M antibody and the other three (0.05%) had autoantibodies in their serum. Conclusion:The combined prevalence for both blood donor and recipient population (n=12,486) was found to be 0.11% at our center. The alloimmunisation among patient population was found to be lower than many other studies worldwide as our hospital does not cater to multitransfused or transfusion dependant patients with haematological disorders and majorly elective surgery patients with no history of previous blood transfusions visit our hospital.www.jcdr.net Daljit Kaur et al., Erythrocyte Alloimmunization and Autoimmunization among Blood Donors and Recipients

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“…However other studies had higher prevalence 0.09-0.13 % [3,4]. These differences in prevalence may be due to variation in the study population and techniques used for detection.…”

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confidence: 51%

Significance of Adopting a Sensitive Technique for Donor Antibody Screening

Chenna

Shastry

Murugesan

2015

Indian J Hematol Blood Transfus

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Frequencies and specificities of red cell alloantibodies in the Southern Thai population

Cited by 30 publications

References 8 publications

The prevalence, alloimmunization risk factors, antigenic exposure, and evaluation of antigen‐matched red blood cells for thalassemia transfusions: a 10‐year experience at a tertiary care hospital

The prevalence, alloimmunization risk factors, antigenic exposure, and evaluation of antigen‐matched red blood cells for thalassemia transfusions: a 10‐year experience at a tertiary care hospital

Erythrocyte Alloimmunization and Autoimmunization among Blood Donors and Recipients visiting a Tertiary Care Hospital

Significance of Adopting a Sensitive Technique for Donor Antibody Screening

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