Frequencies of circulating myeloid derived suppressor cells and dendritic cells in Egyptian patients with chronic Hepatitis C Virus infection undergoing treatment with IFN-α-based therapy

Salem, Mohamed Labib; Zidan, Abdel‐Aziz A.; Senna, Mohamed Abou; Al-Azm, Abdel Raouf Abou; Albatei, Hasan; Aldemelaawy, Maha; Attia, Mohamed

doi:10.1186/2051-1426-1-s1-p248

Cited by 4 publications

(5 citation statements)

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“…Second, viral infections could induce proinflammatory mediators as cytokines (IL‐1 family members, IL‐6, TNF, and IL‐10), lipid mediators (prostaglandin E2 [PGE2]), and growth factors (GM‐CSF), leading to generation of MDSC by enhancing myelopoiesis, skewing differentiation of progenitors into monocytes and DCs (STAT3/STAT5 activation), and promoting survival of M‐MDSC . Moreover, previous studies reported that MDSC confer unfavorable effects on the protective immune responses in patients with chronic HCV infection and their level decreases after successful interferon therapy …”

Section: Discussionmentioning

confidence: 99%

Frequency and Implications of myeloid‐derived suppressor cells and lymphocyte subsets in Egyptian patients with hepatitis C virus‐related hepatocellular carcinoma

Hetta

Zahran²,

Mansor³

et al. 2019

Journal of Medical Virology

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Background and aim: Myeloid-derived suppressor cells (MDSCs) play a pivotal role in tumor immunity and induction of immune tolerance to a variety of antitumor effectors, including T lymphocytes. Herein, we tried to evaluate the frequency and clinical significance of MDSCs and different lymphocyte subsets in hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC). Methods: Four groups were enrolled; chronic HCV (CHC; n = 40), HCV-related liver cirrhosis (n = 40), HCV-related HCC (HCV-HCC; n = 75), and healthy control group (n = 20). The percentage of peripheral lymphocytes subsets and total MDSCs with their main two subsets; monocytic (M-MDSCs) and granulocytic (G-MDSCs) was evaluated by flow cytometry. Results: The frequency of total MSDCs and M-MDSCs was significantly elevated in HCV-HCC especially patients with advanced stage HCC compared with those with early-stage HCC. The frequency of total MSDCs and M-MDSCs was positively correlated with ALT, AFP, and HCV viral load and negatively correlated with CD8 + T-cell frequency. CD4 + T cells were significantly decreased in HCV-HCC patients. The frequency of CD4 + T cells and CD8 + T cells was negatively correlated with AFP and AST, but not with albumin or HCV viral load. Conclusion: Taken together, our data suggest that MDSCs, M-MDSCs, and lymphocyte subsets are associated with the development and progression of HCV-related HCC K E Y W O R D S hepatocellular carcinoma (HCC), hepatitis C Virus (HCV), lymphocytes, myeloid-derived suppressor cells

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Section: Discussionmentioning

confidence: 99%

Frequency and Implications of myeloid‐derived suppressor cells and lymphocyte subsets in Egyptian patients with hepatitis C virus‐related hepatocellular carcinoma

Hetta

Zahran²,

Mansor³

et al. 2019

Journal of Medical Virology

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“…Increased MDSC frequencies positively correlate with HCV viral load and decreased CD8 T-cell function ( 21 , 99 ). Reports show that elevated levels of immature Lin − HLA-DR − CD33 + CD11b + MDSC, consisting of M-MDSC and PMN-MDSC, in chronic HCV-infected patients, decline following successful IFN-α treatment ( 98 ), while treatment-naive HCV-infected individuals show significantly increased liver- and circulating MDSC frequencies compared to treated and uninfected individuals ( 99 , 161 ). Nonetheless, other in vivo investigations failed to show significant MDSC elevations or an association with viral load ( 100 ).…”

Section: M-mdsc In Pathophysiology Of Chronic Infectionsmentioning

confidence: 99%

Monocytic Myeloid-Derived Suppressor Cells in Chronic Infections

Dorhoi

Plessis²

2018

Front. Immunol.

129

131

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Heterogeneous populations of myeloid regulatory cells (MRC), including monocytes, macrophages, dendritic cells, and neutrophils, are found in cancer and infectious diseases. The inflammatory environment in solid tumors as well as infectious foci with persistent pathogens promotes the development and recruitment of MRC. These cells help to resolve inflammation and establish host immune homeostasis by restricting T lymphocyte function, inducing regulatory T cells and releasing immune suppressive cytokines and enzyme products. Monocytic MRC, also termed monocytic myeloid-derived suppressor cells (M-MDSC), are bona fide phagocytes, capable of pathogen internalization and persistence, while exerting localized suppressive activity. Here, we summarize molecular pathways controlling M-MDSC genesis and functions in microbial-induced non-resolved inflammation and immunopathology. We focus on the roles of M-MDSC in infections, including opportunistic extracellular bacteria and fungi as well as persistent intracellular pathogens, such as mycobacteria and certain viruses. Better understanding of M-MDSC biology in chronic infections and their role in antimicrobial immunity, will advance development of novel, more effective and broad-range anti-infective therapies.

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“…We and others have reported that chronic HCV patients harbor high numbers of MDSCs in nonresponders than in responders (Grutzner et al, 2016;Younis et al, 2016;Salem et al, 2017). The responders have the tendency of lower MDSC levels than non-responders (Salem et al, 2013).…”

Section: Introductionmentioning

confidence: 70%

Analysis of Micro RNA 29, 122 and 155 Gene Expression in Immune Cells of Egyptian Patients with Chronic Hepatitis C Virus Infection

Salem,

El-Naggar,

Zidan

et al. 2017

Egyptian Journal of Cancer and Biomedical Research

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Introduction:Infected patients with chronic hepatitis C virus (HCV) showed high numbers of myeloid-derived suppressor cells (MDSCs) which are known to suppress the immune response. Given that microRNAs regulate the expression of many genes, it is important to test whether MDSCs correlate with altered miRNA expression. Aim: The present study aimed to assess the expression of miR-29, 122 and 155 in chronic HCV patients under interferon (IFN) therapy and their correlation with the frequency of MDCS. A total of 28 subjects, including eighteen chronic HCV patients, and 10 healthy volunteers were enrolled in this study. MiR-29, 122 and 155 were evaluated using real-time-polymerase chain reaction (RT-PCR). Flow cytometric analysis was performed to evaluate the MDSCs which defined as Lin -HLA-DR -CD33 + CD11b + . Results: miR-29 and 122 expressions in HCV patients showed significant decrease when compared to their control. However, there was an increase (but non-significance) in miR-155 in HCV patients than control subjects. Both relative and absolute numbers of MDSCs were increased in the peripheral blood in HCV patients as compared to control subjects. Moreover, non-significance change in IFNα/β receptors was observed in HCV patients as compared to control subjects. Conclusion: High numbers of MDSCs in chronic HCV patients correlate with low expression of miR-29 and122.

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Frequencies of circulating myeloid derived suppressor cells and dendritic cells in Egyptian patients with chronic Hepatitis C Virus infection undergoing treatment with IFN-α-based therapy

Abstract: Salem et al.: Frequencies of circulating myeloid derived suppressor cells and dendritic cells in Egyptian patients with chronic Hepatitis C Virus infection undergoing treatment with IFN-αbased therapy.

Cited by 4 publications

References 0 publications

Frequency and Implications of myeloid‐derived suppressor cells and lymphocyte subsets in Egyptian patients with hepatitis C virus‐related hepatocellular carcinoma

Frequency and Implications of myeloid‐derived suppressor cells and lymphocyte subsets in Egyptian patients with hepatitis C virus‐related hepatocellular carcinoma

Monocytic Myeloid-Derived Suppressor Cells in Chronic Infections

Analysis of Micro RNA 29, 122 and 155 Gene Expression in Immune Cells of Egyptian Patients with Chronic Hepatitis C Virus Infection

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