Frequency and anatomic distribution of lymphadenopathic Kaposi's sarcoma in the acquired immunodeficiency syndrome: An autopsy series

Moskowitz, Lee B.; Hensley, George T.; Gould, Edwin W.; Weiss, Steven D.

doi:10.1016/s0046-8177(85)80081-2

Cited by 64 publications

(17 citation statements)

References 19 publications

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“…It is possible that during terminal stages of AIDS, involvement of lymphoid organs is far more common. 21 The fact that none of the 5 splenectomy specimens showed involvement by KS, may reflect the susceptibility of specific sites within lymphoid organs for KS involvement. In the current study, KS involvement of LNs specifically centered on capsule, trabeculae, and hilum.…”

Section: Discussionmentioning

confidence: 99%

“…3,25,26 Although lymphadenopathic KS is relatively uncommon in clinical practice, an earlier autopsy study in AIDS patients showed that more than 90% of patients have microscopic evidence of KS in the LNs or spleen. 21 In the background of these observations, we present here our findings in clinical LN biopsies and splenectomy specimens from HIV-positive patients with MCD and compare them with LN samples without features of MCD from HIV-positive patients.…”

mentioning

confidence: 95%

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Lymph Nodes Involved by Multicentric Castleman Disease Among HIV-positive Individuals are Often Involved by Kaposi Sarcoma

Naresh

Rice

Bower

2008

American Journal of Surgical Pathology

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Multicentric Castleman disease (MCD), a lymphoproliferative disorder and Kaposi sarcoma (KS), a vascular tumor, both occur at a higher frequency among patients with human immunodeficiency virus (HIV) infection. Human herpes virus 8 (HHV8), with an ability to infect and persist in B-lymphoid cells and endothelial cells, is causally associated with both MCD and KS. The coexistence of these HHV8-associated diseases in the same tissue samples has hitherto not been investigated. In this report, we compile the histologic and immunohistochemical findings in 24 lymph node (LN) and 5 spleen samples from 26 patients documented to have HIV-associated MCD. In addition to MCD, 15 of 24 LN samples (63%) showed evidence of coexisting KS. The involvement by KS was typically "microscopic" and involved the LN capsule, trabeculae, or hilum. Examination of 5 spleens involved by MCD did not show any evidence of KS. These were compared with LN biopsies from HIV patients with neither granulomatous diseases, metastatic carcinomas nor lymphoproliferative disorders. Among 20 LN biopsies from 19 individuals without MCD, 5 LNs showed involvement by KS (25%); an association significantly lower than LNs with MCD (Pearson chi 2: 6.2, 2-sided significance: 0.013). Coexistence of MCD and KS in the same tissue sample is a common phenomenon and we hypothesise that the association is due to lytic HHV8 infection of B-lymphoid cells exposing susceptible endothelial cells at vulnerable subsites within the LNs to extremely high levels of HHV8 resulting in formation of KS tumorlets in MCD-LNs.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 95%

Lymph Nodes Involved by Multicentric Castleman Disease Among HIV-positive Individuals are Often Involved by Kaposi Sarcoma

Naresh

Rice

Bower

2008

American Journal of Surgical Pathology

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“…23 The chest x-ray may identify lymphadenopathy and/or intrapulmonary nodules. 24 Pleural fluid characteristics are as follows: -pH mostly greater than 7.44 -mononuclear cell predominance -LDH between 111 and 330 IU/L -Glucose concentration > 3.3 mmol/l 21 Cytological examination of the fluid is unrewarding. 25 A percutaneous pleural biopsy cannot confirm the diagnosis of Kaposi's sarcoma as the lesions are not found on the parietal pleura.…”

Section: Kaposi's Sarcomamentioning

confidence: 99%

“…25 A percutaneous pleural biopsy cannot confirm the diagnosis of Kaposi's sarcoma as the lesions are not found on the parietal pleura. 21 An open-lung biopsy confirms the diagnosis in 75% of cases, but owing to the risk/benefit ratio this procedure is of limited value. 26 The characteristic cherry-red endobronchial lesions found on bronchoscopy, in the proper clinical setting, establish the diagnosis of Kaposi's sarcoma.…”

Section: Kaposi's Sarcomamentioning

confidence: 99%

The pleural effusion in HIV—an approach to diagnosis

Mostert

Pannell

2009

South African Family Practice

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“…It has been found Table 3. Cutaneous Findings in Patients with AIDS at autopsy, however, in more than 90% of patients in a variety of risk groups, usually in the lymph nodes and spleen [27]. Skin involvement is characterized by lesions that vary from brown macules to blue-violet nodules, plaques, or tumors [26].…”

Section: Acquired Immunodeficiency Syndromementioning

confidence: 99%