Frequency and antimicrobial susceptibility of clinical isolates of enterococci

Guiney, Michael; Urwin, Gillian

doi:10.1007/bf01964435

Cited by 20 publications

(6 citation statements)

References 24 publications

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“…faecalis was the species more frequently isolated from all clinical samples as reported in previous studies (Murray 1990;Guiney and Urwin 1993;Facklam and Sahm 1995;Pangon et al 1999). The finding that approximately 25% of E. faecalis isolates and over 75% of E. faecium isolates were resistant to penicillin and ampicillin has great importance, since penicillin and ampicillin are the main drugs in the treatment of enterococcal infections (Murray 2000).…”

Section: Discussionsupporting

confidence: 62%

Susceptibility Patterns of Enterococci Causing Infections

Öncü

Punar

Eraksoy

2004

Tohoku J. Exp. Med.

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Enterococci are among the common organisms associated with hospital-acquired infections. We examined in vitro activities of different antibiotics to 103 enterococcal isolates. Minimal inhibitory concentrations (MICs) of penicillin G, ampicillin, gentamicin, ciprofloxacin, ofloxacin, levofloxacin, grepafloxacin, trovafloxacin and gemifloxacin were determined by broth microdilution testing method. Among the isolates 71 (69%) were identified as E. faecalis and 32 (31%) as E. faecium. While over 75% of E. faecium isolates were resistant to penicillin and ampicillin, approximately 25% of E. faecalis isolates were resistant to penicillin and ampicillin. None of the E. faecalis and E. faecium isolates were resistant to vancomycin. While 17 (52%) of E. faecium isolates exhibited high-level gentamicin resistance (HLGR), high level streptomycin resistance (HLSR) was detected in 24 (74%) of the isolates. In contrast, HLGR and HLSR rates for E. faecalis were 14 (20%) and 22 (31%), respectively. Both HLGR and HLSR were detected with higher frequency in ampicillin resistant isolates. Among fluoroquinolones, gemifloxacin and trovafloxacin were the most potent antibiotics tested. There was no increase in MIC 90 values of the fluoroquinolones in ampicillin resistant isolates in comparison with ampicillin susceptible isolates. Our data suggest newer fluoroquinolones would be good alternative agents to use especially for combination drug therapy where enterococci with ampicillin resistance and HLAR are prevalent.enterococci; susceptibility; infection

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Section: Discussionsupporting

confidence: 62%

Susceptibility Patterns of Enterococci Causing Infections

Öncü

Punar

Eraksoy

2004

Tohoku J. Exp. Med.

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“…Our finding that over 95% of enterococcal isolates were susceptible to ampicillin is consistent with the previous reports for bovine mastitis from many other countries (Pitkälä et al., 2004; Tenhagen et al., 2006). While ampicillin is generally known to be the drug of choice to treat enterococcal infections (Guiney and Urwin, 1993), nosocomial outbreaks caused by ampicillin ‐ resistant E. faecium were reported in many countries (Quiñones et al., 2005; Lester et al., 2008), suggesting the need for continued monitoring of enterococci resistant to this antimicrobial.…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial Resistance of Enterococci Isolated from Mastitic Bovine Milk Samples in Korea

Nam

Lim

Moon

et al. 2010

Zoonoses and Public Health

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The aim of this study was to determine the antimicrobial resistance of various species of enterococci isolated from mastitic bovine milk samples. A total of 105 enterococci isolates were examined: Enterococcus faecalis (n = 47), Enterococcus faecium (n = 39), Enterococcus gallinarum (n = 6), Enterococcus avium (n = 6), Enterococcus hirae (n = 5) and Enterococcus durans (n = 2). All the isolates were susceptible to ampicillin, gentamicin and vancomycin, and only a single E. hirae isolate was resistant to ampicillin. In general, the most frequently observed resistance among the enterococcal isolates was to tetracycline (69.5%), followed by penicillin (64.7%), erythromycin (57.1%) and cephalothin (44.7%). A similar antimicrobial resistance pattern was observed among individual species except E. durans, which exhibited only tetracycline resistance. Resistance observed among isolates of E. hirae and E. gallinarum was almost as high as E. faecium and E. faecalis. Of 105 isolates, only six (5.7%) strains of E. faecium were susceptible to all the antimicrobials tested and about 52% (55/105) showed resistance to more than three antimicrobials. The most common multiple resistance pattern was penicillin, tetracycline and erythromycin, which was observed in 32 of 105 (30.4%) isolates. This study demonstrates that enterococcal isolates belonging to minor species showed antimicrobial resistance rates as high as those of E. faecium and E. faecalis, and that monitoring of antimicrobial resistance should not be restricted only to those two major species.

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“…Also in domestic studies, the prevalence of vancomycin-resistant Enterococci was reported to be 4.7%, 5.6%, 12%, and 23%, respectively [25][26][27][28]. However, Salah et al [29], Loza et al [30], And Guiney [31] did not find any Enterococci resistant to vancomycin. The study of 414 Enterococci, 19(4.6%) isolates of vancomycin resistant Enterococci were identified.…”

Section: Discussionmentioning

confidence: 99%