Frequency and antimicrobial susceptibility of Shigella species isolated in Children Medical Center Hospital, Tehran, Iran, 2001-2006

Pourakbari, Babak; Mamishi, Setareh; Mashoori, Negar; Mahboobi, Nima; Ashtiani, Mohammad H.; Afsharpaiman, Shahla; Abedini, Masomeh

doi:10.1016/s1413-8670(10)70029-5

Cited by 29 publications

(31 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Fortunately, no resistance was found against ciprofloxacin and imipenem in our study. This finding is similar to results of other studies from Iran, in which all of the Shigella isolates showed susceptibility to these antibiotics (6,18,19). The World Health Organization (WHO) currently recommends ciprofloxacin for all patients with bloody diarrhea, irrespective of age, with ceftriaxone as an alternative agent in adults and children (25).…”

Section: Discussionsupporting

confidence: 87%

See 1 more Smart Citation

Prevalence and Antibiotic Susceptibility of Shigella Species Isolated From Pediatric Patients in Tehran

Talebreza

Memariani

et al. 2015

Arch Pediatr Infect Dis

View full text Add to dashboard Cite

Background: Dysentery accounts for a significant proportion of morbidity and mortality cases, especially in children with diarrhea in developing countries. Shigellosis remains a public health problem in Iran. Objectives: The objectives of this study were to investigate the presence and the frequency of Shigella spp. among children younger than 10 years with diarrhea and to determine the antimicrobial resistance patterns of these isolates in Tehran, Iran. Patients and Methods: This cross-sectional study was conducted in two pediatric hospitals in Tehran, from October, 2013 to October, 2014. Nine hundred and thirty-eight (n = 938) stool samples were collected (one stool per patient) from children less than 10 years of age. The stools were primarily cultured on MacConkey agar and xylose lysine deoxycholate (XLD). (Selenite-F broth is also used as an enrichment medium for the isolation of Shigella spp.) All of the isolates were confirmed as Shigella species by biochemical and serological tests. Molecular confirmation of Shigella isolates was determined by polymerase chain reaction (PCR) using specific primers for the ipaH gene. The antibiotic susceptibility of the Shigella isolates was tested using the Kirby-Bauer disc-diffusion method. Results: Amongst 938 stool samples, 36 were Shigella spp. S. sonnei (61.1%, n = 22), which was the most common, followed by S. flexneri (27.8%, n = 10), S. boydii (8.3%, n = 3), and S. dysenteriae (2.8%, n = 1). Furthermore, most Shigella isolates showed resistance to amoxicillin (83.3%), tetracycline (61.1%), and co-trimoxazole (83.3%). No resistance was found against ciprofloxacin and imipenem. This study showed that S. sonnei is currently the predominant species in Tehran, Iran. Conclusions: Because resistance to antibiotics changes constantly, Shigella strains should be under surveillance in order to monitor local susceptibility and subsequently formulate policies for the use of antimicrobial drugs.

show abstract

Section: Discussionsupporting

confidence: 87%

“…However, Shigella species have become progressively resistant to most widely-used antibiotics such as ampicillin, chloramphenicol, tetracycline, and trimethoprim-sulfamethoxazole. Furthermore, the emergence of resistance to third-generation cephalosporins in Shigella is a matter of great concern, mainly in developing countries (5,6).…”

Section: Introductionmentioning

confidence: 99%

Prevalence and Antibiotic Susceptibility of Shigella Species Isolated From Pediatric Patients in Tehran

Talebreza

Memariani

et al. 2015

Arch Pediatr Infect Dis

View full text Add to dashboard Cite

show abstract

“…The major cluster (cluster C) constituted 75.7% of the total isolates, all of which (except eight isolates) consonantly showed identical class 2 integron of 1500 bp which strongly suggests the dissemination of a single S. sonnei clone among the pediatric population in 2012 autumn in Tehran, Iran, in comparison with the equal data from the comparable time period from recent years (Eftekhari et al, 2013;Farshad et al, 2006;Ghaemi et al, 2007;Pourakbari et al, 2010;Savadkoohi and Ahmadpour-Kacho, 2007). Antimicrobial resistance, integron content and tetracycline resistance gene patterns showed a minor discrepancy among isolates with identical PFGE genotypes.…”

Section: Discussionmentioning

confidence: 76%

Clonal dissemination of a single Shigella sonnei strain among Iranian children during Fall 2012 in Tehran, I.R. Iran

Alizadeh-Hesar

Bakhshi

Peerayeh

2015

Infection, Genetics and Evolution

View full text Add to dashboard Cite

“…especially S. flexneri. 13 In summary, this study reported five cases of lethal toxic encephalopathy associated with shigellosis or Ekiri syndrome. Death occurred following rapid neurological detoriation resulting in brain edema despite intensive treatment.…”

Section: Discussionmentioning

confidence: 72%

“…In a recent study, the most common species of Shigella in Iranian children were S. flexneri (48%) and S. sonnei (45%). 13 The pathogenesis of lethal encephalopathy due to shigellosis or Ekiri remains unknown. It has been postulated that Shiga toxin, which is only produced by Shigella dysenteriae type 1, plays a role.…”

Section: Discussionmentioning

confidence: 99%

Lethal toxic encephalopathy due to childhood shigellosis or Ekiri syndrome

Pourakbari

Mamishi

Kohan

et al. 2012

Journal of Microbiology, Immunology and Infection

Self Cite

View full text Add to dashboard Cite

Lethal toxic encephalopathy due to shigellosis or Ekiri syndrome is a rare complication of shigellosis with a high fatality rate. Data are very limited on factors that can predict this encephalopathy, so we evaluated clinical and laboratory characteristics for these patients. In this study children with extreme toxicity and convulsions followed by rapid neurological deterioration resulting in brain edema and fatal outcome without sepsis and severe dehydration were selected as having lethal toxic encephalopathy. There were 1295 children with shigellosis during the 10 years of the study. Five children (0.4%) had lethal toxic encephalopathy due to shigellosis. Death occurred following rapid neurological detoriation resulting in brain edema despite intensive treatment. Evidence of brain edema may be a prediction factor for death. Early recognition of encephalopathy and measures to prevent brain edema may improve patient outcome.

show abstract

Frequency and antimicrobial susceptibility of Shigella species isolated in Children Medical Center Hospital, Tehran, Iran, 2001-2006

Cited by 29 publications

References 24 publications

Prevalence and Antibiotic Susceptibility of Shigella Species Isolated From Pediatric Patients in Tehran

Prevalence and Antibiotic Susceptibility of Shigella Species Isolated From Pediatric Patients in Tehran

Clonal dissemination of a single Shigella sonnei strain among Iranian children during Fall 2012 in Tehran, I.R. Iran

Lethal toxic encephalopathy due to childhood shigellosis or Ekiri syndrome

Contact Info

Product

Resources

About