Frequency and characteristics of HTLV in migrants: results from the +Redivi collaborative network in Spain

Norman, Francesca; Salvador, Fernando; Gullón, Beatriz; Díaz‐Menéndez, Marta; Pérez‐Ayala, Ana; Rodríguez-Guardado, Azucena; García-Rodríguez, Magdalena; Henriquez-Camacho, Cesar; Goikoetxea, Josune; Bosch-Nicolau, Pau; Calle, Fernando; Ramos-Rincón, José-Manuel; Aznar, Maria-Luisa; Peñaranda, María; Calabuig, Eva; Suárez‐García, Inés; Pérez‐Molina, José A.; López‐Vélez, Rogelio

doi:10.1093/jtm/taac019

Cited by 3 publications

(2 citation statements)

References 25 publications

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“…Roughly 15% had clinical manifestations linked to HTLV-1, being the rest asymptomatic. 26 The molecular epidemiology of HTLV-1 in Spain has been examined in 94 samples. Subtype A is present in all but two Africans that carry subtype B.…”

Section: Migrantsmentioning

confidence: 99%

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The slowdown of new infections by human retroviruses has reached a plateau in Spain

Mendoza

Carrizo

Sauleda

et al. 2023

Journal of Medical Virology

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The 2022 annual meeting of the HTLV & HIV-2 Spanish Network was held in Madrid on December 14. We summarize here the main information presented and discussed at the workshop and review time trends for human retroviral infections in Spain. As transmissible agents, infections by human retroviruses are of obligatory declaration.Until the end of 2022, the Spanish national registry had recorded 451 cases of HTLV-1, 821 of HTLV-2, and 416 of HIV-2. For HIV-1, estimates are of 150 000 people currently living with HIV-1 and 60 000 cumulative deaths due to AIDS.During year 2022, new diagnoses in Spain were of 22 for HTLV-1, 6 for HTLV-2, and 7 for HIV-2. The last updated figures for HIV-1 are from 2021 and counted 2786 new diagnoses. The slowdown in yearly infections for HIV-1 in Spain points out that new strategies are needed to achieve the United Nations 95-95-95 targets by 2025.

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Section: Migrantsmentioning

confidence: 99%

“…Most cases were from Latin America and Sub‐Saharan Africa. Roughly 15% had clinical manifestations linked to HTLV‐1, being the rest asymptomatic 26 . The molecular epidemiology of HTLV‐1 in Spain has been examined in 94 samples.…”

Section: Htlv‐1 Epidemicsmentioning

confidence: 99%

The slowdown of new infections by human retroviruses has reached a plateau in Spain

Mendoza

Carrizo

Sauleda

et al. 2023

Journal of Medical Virology

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Trends in imported malaria during the COVID-19 pandemic, Spain (+Redivi Collaborative Network)

Norman

Treviño-Maruri

Giardín

et al. 2022

Journal of Travel Medicine

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Introduction The COVID-19 pandemic has caused disruptions in prevention and management strategies for malaria globally. Currently, data analysing trends in travel-related infections during the pandemic years are scarce. The objective of this analysis was to describe the epidemiological and clinical characteristics of patients with imported malaria within the +Redivi network in Spain, focusing on yearly trends from pre-pandemic years to date. Methods Cases recorded in +Redivi from October 2009 to December 2021 were analysed and patients with a diagnosis of malaria (standard diagnostic methods using thick/thin peripheral blood smears, with/without a malaria rapid diagnostic test and/or Plasmodium spp. PCR) were identified. The total number of malaria cases, cases according to type of patient and severe cases, per year, were analysed. Results In total, 1751 cases of malaria (1751/26601, 6.6%) were identified. The majority occurred in males (1041, 59.5%), median age was 36.3 (IQR: 27–44.7) years and most occurred in VFR-immigrants (872, 49.8%). Most infections were acquired in sub-Saharan Africa (1.660, 94.8%) and were due to P. falciparum (81.3%). There were 64 cases of severe malaria (3.7%) and 4 patients died (0.2% mortality, all in pre-pandemic years). A significant increase in cases of severe malaria was observed during the study period (p < 0.001)(attributable to the increase in 2021). There were 16/93 severe cases in 2021 (17.2%), all due to P. falciparum, (compared with ≤ 5% in previous years), which mainly occurred in travellers and VFR-immigrants (10/16, 62.5% and 5/16, 31.3%, respectively). Conclusions After an initial decline associated with travel restrictions due to the ongoing COVID-19 pandemic, an increase in imported malaria and a significant increase in cases of severe malaria was observed. Patients with imported malaria may present and/or be diagnosed late during this public health crisis and health care professionals should be alerted to the recent increase in severe cases.

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HTLV-2 Enhances CD8+ T Cell-Mediated HIV-1 Inhibition and Reduces HIV-1 Integrated Proviral Load in People Living with HIV-1

Abad-Fernández

Hernández-Walias

León

et al. 2022

Viruses

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People living with HIV-1 and HTLV-2 concomitantly show slower CD4+ T cell depletion and AIDS progression, more frequency of the natural control of HIV-1, and lower mortality rates. A similar beneficial effect of this infection has been reported on HCV coinfection reducing transaminases, increasing the spontaneous clearance of HCV infection and delaying the development of hepatic fibrosis. Given the critical role of CD8+ T cells in controlling HIV-1 infection, we analysed the role of CD8+ T cell-mediated cytotoxic activity in coinfected individuals living with HIV-1. One hundred and twenty-eight individuals living with HIV-1 in four groups were studied: two groups with HTLV-2 infection, including individuals with HCV infection (N = 41) and with a sustained virological response (SVR) after HCV treatment (N = 25); and two groups without HTLV-2 infection, including individuals with HCV infection (N = 25) and with a sustained virological response after treatment (N = 37). We found that CD8+ T cell-mediated HIV-1 inhibition in vitro was higher in individuals with HTLV-2. This inhibition activity was associated with a higher frequency of effector memory CD8+ T cells, higher levels of granzyme A and granzyme B cytolytic enzymes, and perforin. Hence, cellular and soluble cytolytic factors may contribute to the lower HIV-1 pre-ART viral load and the HIV-1 proviral load during ART therapy associated with HTLV-2 infection. Herein, we confirmed and expanded previous findings on the role of HTLV-2 in the beneficial effect on the pathogenesis of HIV-1 in coinfected individuals.

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Frequency and characteristics of HTLV in migrants: results from the +Redivi collaborative network in Spain

Cited by 3 publications

References 25 publications

The slowdown of new infections by human retroviruses has reached a plateau in Spain

The slowdown of new infections by human retroviruses has reached a plateau in Spain

Trends in imported malaria during the COVID-19 pandemic, Spain (+Redivi Collaborative Network)

HTLV-2 Enhances CD8+ T Cell-Mediated HIV-1 Inhibition and Reduces HIV-1 Integrated Proviral Load in People Living with HIV-1

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