Frequency and clinical manifestations of post-poliomyelitis syndrome in a brazilian tertiary care center

Quadros, Abrahão Augusto Juviniano; Conde, Mônica Tilli Reis Pessoa; Marin, Luís Fabiano; Silva, Helga Cristina Almeida da; Silva, Tatiana Mesquita e; Paula, Maria Bernadete Eduardo de; Pereira, Roberto Dias Batista; Ramos, Paulo Eduardo; Abe, G.C.; Oliveira, Acary Souza Bullé

doi:10.1590/s0004-282x2012000800002

Cited by 11 publications

(12 citation statements)

References 7 publications

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“…For many geographic areas these data are totally missing. Data from polio associations and/or publications are available for some countries, including Australia (http://www.polio.org.au/about-polioaustralia/), 71,72 Brazil, 73,74 Canada, 16 Denmark (http://www. polioplace.org/resources/ptu-danish-society-polio-and-accidentvictims-landsforeningen-af-polio-trafik-og-ulykkessk), 13 France, 75 Germany, 76 Italy, 77,78 Japan, 79 Norway, 10 Poland, 80 Spain, 81 Sweden, 82,83 the UK, 84 and the USA (http://www.post-polio.org/ ir-usa.html).…”

Section: Epidemiology: Polio Survivors and Ppsmentioning

confidence: 99%

Post-poliomyelitis syndrome as a possible viral disease

Baj

Colombo

Headley³

et al. 2015

International Journal of Infectious Diseases

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This review summarizes current concepts on post-polio syndrome (PPS), a condition that may arise in polio survivors after partial or complete functional recovery followed by a prolonged interval of stable neurological function. PPS affects 15-20 million people worldwide. Epidemiological data are reported, together with the pathogenic pathways that possibly lead to the progressive degeneration and loss of neuromuscular motor units. As a consequence of PPS, polio survivors experience new weakness, generalized fatigue, atrophy of previously unaffected muscles, and a physical decline that may culminate in the loss of independent life. Emphasis is given to the possible pathogenic role of persistent poliovirus infection and chronic inflammation. These factors could contribute to the neurological and physical decline in polio survivors. A perspective is then given on novel anti-poliovirus compounds and monoclonal antibodies that have been developed to contribute to the final phases of polio eradication. These agents could also be useful for the treatment or prevention of PPS. Some of these compounds/antibodies are in early clinical development. Finally, current clinical trials for PPS are reported. In this area, the intravenous infusion of normal human immunoglobulins appears both feasible and promising.

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Section: Epidemiology: Polio Survivors and Ppsmentioning

confidence: 99%

Post-poliomyelitis syndrome as a possible viral disease

Baj

Colombo

Headley³

et al. 2015

International Journal of Infectious Diseases

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“…The clinical and epidemiological aspects of PPS in the Brazilian population were evaluated through two studies performed in 2009 and 2012 (Conde et al, 2009; Quadros et al, 2012). The two studies included 132 and 129 patients with a mean age of 39 years after the onset of the syndrome and after a period of 30–35 years of functional stability.…”

Section: Introductionmentioning

confidence: 99%

“…The most common symptoms were fatigue (87.1% and 77.5%), muscle pain (82.4% and 76.0%), and joint pain (72.0% and 79.8%), respectively. Approximately 50% of the cases were severe cases, which were defined as cases with patients who required assistance in walking and/or presented with severe sleep apnea (Quadros et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

A twelve‐week, four‐arm, randomized, double‐blind, placebo‐controlled, phase 2 prospective clinical trial to evaluate the efficacy and safety of an anthroposophic multimodal treatment on chronic pain in outpatients with postpolio syndrome

et al. 2020

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Introduction: Chronic pain and fatigue are the main symptoms of postpoliomyelitis syndrome (PPS). This study aimed to evaluate the efficacy and safety of an anthroposophic multimodal treatment for chronic pain in PPS outpatients. Methods: A twelve-week, four-arm, randomized, double-blind, placebo-controlled, phase 2 prospective clinical trial was designed to compare four groups (n = 48): groups A and B received daily active experimental transdermal gel (ETG) or placebo gel (PTG), respectively; groups C and D received weekly external therapies, art therapies, and neurofunctional reorganization, plus either daily ETG or PTG, respectively. The pain symptoms were evaluated through a visual analogue scale (VAS), the McGill questionnaire, and thermography. Quality of life and resilience were evaluated by the WHOQOL-BREF and Antonovsky sense of coherence questionnaires applied at baseline and after the interventions.Results: No related adverse events occurred, and 10% of the patients reports dysphagia improvement. In the groups C and D, pain reduction was statistically significant in both the placebo group (p = .02, d = 1.315) and in the ETG (p = .005, d = 2.035).However, following the week-to-week evolution of pain with the concomitant use of the ETG, this significant pain reduction occurred earlier from the 4th week and continued to decrease (p = .016, d = 1.369). In the group that received the complete multimodal treatment, the greatest significant benefit in increasing quality of life occurred in the physical domain and elevation in resilience with an emphasis on meaning and comprehension domains. Conclusions:The anthroposophic multimodal treatment group presented both safety and efficacy as an analgesic in the groups that received the nonpharmacological therapies, much earlier when associated with the ETG. The multimodal approach

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“…Approximately 69.8% of individuals with PPS in Brazil exhibit CI. On clinical examination, the affected limbs are abnormally cold due to affected sympathetic nerve cells [5]. The etiology of CI has not yet been established, and there is no specific treatment for it; the affected individuals are advised to wear appropriate clothes, perform distal/proximal massages and apply local heat over short periods of time [6].…”

mentioning

confidence: 99%

Immediate and Long-Term Effects of Qigong on Cold Intolerance in Patients with Post-Poliomyelitis Syndrome

Ramos¹,

Abe²,

Pradella-Hallinan³

et al. 2018

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Post-poliomyelitis syndrome (PPS) is a disorder in individuals who have had poliomyelitis, characterized by new muscle weakness and often associated with other symptoms, including cold intolerance (CI). Qigong is a Traditional Chinese Medicine technique to adjust energy and blood circulation. Objective: To verify the effects and late repercussions of Qigong on CI complaints in PPS patients. Methods: PPS patients (n = 22, 14 females, 8 males; ages 35 -60) performed Qigong exercises in 40-minute sessions, three times per week, for three consecutive months. They were evaluated at baseline, the end of treatment and every three months for a year using a visual analogue scale adapted for CI (VAS-cold). Results: The systemic VAS-cold scores exhibited significant differences between the baseline, the end of treatment and throughout 12 months of follow-up. Conclusion: The CI scores were low and bearable at the end of intervention and for the following 12 months without activity.

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Frequency and clinical manifestations of post-poliomyelitis syndrome in a brazilian tertiary care center

Abstract: Most patients of our sample presented PPS. In Brazil, PPS frequency and clinical features are quite similar to those of other countries.

Cited by 11 publications

References 7 publications

Post-poliomyelitis syndrome as a possible viral disease

Post-poliomyelitis syndrome as a possible viral disease

A twelve‐week, four‐arm, randomized, double‐blind, placebo‐controlled, phase 2 prospective clinical trial to evaluate the efficacy and safety of an anthroposophic multimodal treatment on chronic pain in outpatients with postpolio syndrome

Immediate and Long-Term Effects of Qigong on Cold Intolerance in Patients with Post-Poliomyelitis Syndrome

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