Frequency and Effects of Bacterial Infection in Children with Influenza Under Oseltamivir Treatment

Ninomiya, Keiko; Madenokouji, Naoki; Hajikano, Miharu; Kawabata, K.; Matsuoka, Kazuhiko; Fukunaga, Yoshitaka

doi:10.1272/jnms.73.122

Cited by 2 publications

(1 citation statement)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Influenza A infection can cause severe pneumonia, bronchiolitis and encephalopathy, and may be complicated by prolonged secondary bacterial superimposed infection, even in patients treated with OSV 6 . Problems associated with OSV use include a high rate of viral neuraminidase mutation, the development of drug‐resistant viruses 5,7 .…”

Section: Introductionmentioning

confidence: 99%

Boost of mucosal secretory immunoglobulin A response by clarithromycin in paediatric influenza

et al. 2009

View full text Add to dashboard Cite

Background and objective:The antiviral neuraminidase inhibitor oseltamivir (OSV) is used to treat influenza. The macrolide clarithromycin (CAM) is used to treat bacterial infections and has anti-inflammatory and immunomodulatory activities. This retrospective study investigated the immunomodulatory effects of CAM in children presenting with influenza A. Methods: The study recruited 40 children with acute influenza, and grouped them according to the treatment received: 5-day treatment with OSV (n = 14), CAM (n = 8), OSV + CAM (n = 12) and untreated (n = 6). The before and after treatment comparisons were made of the level of secretory IgA (sIgA) against influenza A virus (H3N2) and (H1N1), total sIgA, viral RNA copy numbers in nasopharyngeal aspirates and disease symptoms. Results: Infection induced anti-viral mucosal sIgA in the nasopharyngeal aspirates of most patients of all treatment groups. Particularly prominent increases in the levels were found in the CAM and OSV + CAM groups. Low induction of anti-viral sIgA was observed in the OSV group, but the addition of CAM to OSV augmented sIgA production and restored local mucosal sIgA levels. The frequency of residual cough in the OSV + CAM group was significantly lower than in the other groups including the group treated with OSV. Conclusions: CAM boosted the nasopharyngeal mucosal immune response in children presenting with influenza A, even in those treated with OSV who had low production of mucosal anti-viral sIgA, and alleviated the symptoms of influenza.

show abstract

Section: Introductionmentioning

confidence: 99%

Boost of mucosal secretory immunoglobulin A response by clarithromycin in paediatric influenza

et al. 2009

View full text Add to dashboard Cite

show abstract

Antigenic Complementarity between Influenza A Virus and Haemophilus influenzae may Drive Lethal Co-Infection Such as that Seen in 1918-19 Pandemic

Root‐Bernstein

Podufaly²,

Aimone³

2013

J Virol Antivir Res

View full text Add to dashboard Cite

Frequency and Effects of Bacterial Infection in Children with Influenza Under Oseltamivir Treatment

Abstract: Background: New antiviral drugs can rapidly improve the symptoms of influenza, but

Cited by 2 publications

References 12 publications

Boost of mucosal secretory immunoglobulin A response by clarithromycin in paediatric influenza

Boost of mucosal secretory immunoglobulin A response by clarithromycin in paediatric influenza

Antigenic Complementarity between Influenza A Virus and Haemophilus influenzae may Drive Lethal Co-Infection Such as that Seen in 1918-19 Pandemic

Contact Info

Product

Resources

About