Frequency and Genotype of Hepatitis D Virus Infection in Patients Infected with HIV and Those Undergoing Hemodialysis

Aghasadeghi, Mohammad Reza; Mohraz, Minoo; Bahramali, Golnaz; Aghakhani, Arezoo; Banifazl, Mohammad; Foroughi, Maryam; Ahmadi, Farrokhlagha; Eslamifar, Ali; Sadat, Seyed Mehdi; Ramezani, Amitis

doi:10.5812/hepatmon.7481

Cited by 15 publications

(17 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous HDV and HEV studies have reported the presence of HEV and HDV infections in different regions of the Iran (13, 22); however, there is not enough information regarding HIV co -infection in the Iran. In another study, HIV infected patients has also been reported a low anti -HDV prevalence in the Iran, however, the number of patients is increasing (21). The finding of the present study showed that ALT mean levels among group II and group III patients were higher than that among group I patients.…”

Section: Discussionsupporting

confidence: 44%

See 1 more Smart Citation

Sero - Epidemiology of Hepatitis E and D Infections among HIV - Infected and HIV/HCV - Coinfected Patients in Jahrom, Southern Iran

Shadmand

Baharlou

Shokouh

et al. 2018

Arch Clin Infect Dis

View full text Add to dashboard Cite

Background: Co -infection of hepatitis E virus (HEV) and hepatitis D virus (HDV) in human immunodeficiency virus (HIV) infected patients can develop and increase hepatic complications in the world, particularly in developing countries. Objectives: The purpose of this study was to assess and compare the sero -virological prevalence of HEV and HDV in patients bearing HIV infection and HIV/HCV co -infection, as well as their relation to clinical and demographic data. Methods: Cross -sectional study testing IgM/IgG anti -HEV and total antibodies HDV in serum samples belong to 73 HIV infected patients and co -infected HIV -HCV patients were evaluated. Demographic, lifestyle, and laboratory data such as CD4 counts and viral load were prospectively collected on each patient with the HIV infection. Results: There were 26 HEV infected patients IgG positive, two HEV infected patients IgM positive, two HDV infected patients total antibodies positive, and only one HDV infected patient IgM among the 73 HIV infected patients. The prevalence of HDV positive IgG and total anti -HDV among co -infected patients were 2.2% and 2.2%. In addition 18 (69.2%) and 2.2% were positive for anti -HEV IgG and IgM, respectively. Furthermore, HIV viral load among HIV co -infected patients with HEV or HDV were shown higher compared to patients solely infected with only HIV. Also, the numbers of HEV or HDV positive were high in low levels of CD4. Conclusions: According to the results, frequency of occurrence of hepatitis E was higher than hepatitis D in HIV infected patients. Severity of HIV infection and liver damage caused by HEV and HDV infections were in a direct relationship. Hence, HIV and HCV screening should be implemented in HIV -infected patients with liver damage.

show abstract

Section: Discussionsupporting

confidence: 44%

“…Thus, in a study in 2013 by Aghasadeghi et al, it was reported that the HDV infection in patients infected with HIV was among undergoing hemodialysis (21). In another study in Bushehr (South of Iran), Naeimi et al, showed positive serological cases for HEV among blood donors (22).…”

Section: Introductionmentioning

confidence: 95%

Sero - Epidemiology of Hepatitis E and D Infections among HIV - Infected and HIV/HCV - Coinfected Patients in Jahrom, Southern Iran

Shadmand

Baharlou

Shokouh

et al. 2018

Arch Clin Infect Dis

View full text Add to dashboard Cite

show abstract

“…Nested PCR gained popularity in the early 1990s after Nichol and colleagues used nested PCR reactions to identify a novel hantavirus during an outbreak of a highly pathogenic acute respiratory illness (Nichol et al, 1993). Nested PCR reactions have been employed to detect a number of viruses (Aghasadeghi et al, 2013; Lam et al, 2007; Song et al, 2009), but not yet for RVA until this study.…”

Section: Discussionmentioning

confidence: 99%

Sensitive and specific nested PCR assay for detection of rotavirus A in samples with a low viral load

Mijatovic-Rustempasic

Esona

Williams

et al. 2016

Journal of Virological Methods

View full text Add to dashboard Cite

Techniques such as the real-time reverse transcription-polymerase chain reaction (qRT-PCR) can detect RNA in samples with a low viral load. However, these amplicons typically are either too short or at insufficient concentrations for use in subsequent sequencing reactions for genotyping and detection confirmation. The assay developed in this study detects rotavirus G genotypes and P genotypes with viral loads as low as 6.2 and 8.2 copies per reaction, respectively. The assay was validated using a panel of 91 stool samples, 32 reference rotavirus strains, and 6 non-target enteric virus samples.

show abstract

“…In another study on 606 HBsAg-positive patients in Mashhad, HDVAb was found in the serum of 35 patients, representing a prevalence of around 5.8% (7). Another study on patients, who were receiving hemodialysis in Tehran found that 7.5% of the cases were HBsAg-positive and 33.3% of HBsAg-positive patients were HDVAb-positive (8). However, a study on 153 hemodialysis patients in the south of Iran showed that nine (5.88%) were HBsAg-positive and none suffered from hepatitis D (9).…”

Section: Introductionmentioning

confidence: 97%

“…The current findings also showed that the prevalence of HBsAg positivity among 108 hemodialysis patients was 3.7%. Previous studies in Iran reported that 5.88% to 7.5% of hemodialysis patients were HBsAg-positive (8,9,19,20). This rate among 76 hemodialysis and BTM patients in Iran was 7.89% (21).…”

Section: P R O O Fmentioning

confidence: 99%

The Prevalence of Hepatitis B Surface Antigen and Hepatitis D Virus Antibody Positivity Among Hemodialysis Patients and Patients With Beta-Thalassemia Major

Momen‐Heravi

Afzali

2018

Mod Care J

View full text Add to dashboard Cite

Background: Patients, who receive hemodialysis and patients with beta-thalassemia major are at great risk for blood-borne viral infections, chiefly different types of hepatitis. Objectives: This study aimed at assessing the prevalence of hepatitis B and D among hemodialysis patients and patients with betathalassemia major in Kashan, Iran. Methods: This cross-sectional study was conducted in 2016 on 108 patients on hemodialysis and 34 patients with beta-thalassemia major in Kashan, Iran. After explaining the aim of the study to the participants and securing their informed consents, data on their demographic and health-related characteristics were collected through a questionnaire. Then, a five-milliliter venous blood sample was obtained from each participant and tested using enzyme-linked immunosorbent assay technique for hepatitis B surface antigen and hepatitis D virus antibody. The data were entered in the SPSS program (v. 16.0) and analyzed using the Chi-square and the independent-sample t tests. Results: The prevalence of hepatitis B surface antigen positivity among patients on hemodialysis and patients with beta-thalassemia major was 3.7% and 8.8%, respectively. Moreover, the prevalence of hepatitis D virus antibody positivity among these patients was 2.9% and 1.9%, respectively. The prevalence of hepatitis B surface antigen positivity among patients on hemodialysis had a significant relationship with history of addiction and history of unprotected sex. Conclusions:The prevalence of hepatitis B and D was respectively 3.7% and 8.8% among hemodialysis patients and 2.9% and 1.9% among patients with beta-thalassemia major. Effective strategies should be employed to minimize the risks of hepatitis B and D transmission among hemodialysis patients and patients with beta-thalassemia major. Moreover, regular screening programs are needed for early diagnosis and treatment of viral hepatitis among these patients.

show abstract

Frequency and Genotype of Hepatitis D Virus Infection in Patients Infected with HIV and Those Undergoing Hemodialysis

Cited by 15 publications

References 33 publications

Sero - Epidemiology of Hepatitis E and D Infections among HIV - Infected and HIV/HCV - Coinfected Patients in Jahrom, Southern Iran

Sero - Epidemiology of Hepatitis E and D Infections among HIV - Infected and HIV/HCV - Coinfected Patients in Jahrom, Southern Iran

Sensitive and specific nested PCR assay for detection of rotavirus A in samples with a low viral load

The Prevalence of Hepatitis B Surface Antigen and Hepatitis D Virus Antibody Positivity Among Hemodialysis Patients and Patients With Beta-Thalassemia Major

Contact Info

Product

Resources

About