Frequency and Levels of Autoantibodies in Healthy Adult Omanis

Al-Jabri, Ali A.; Belushi, Mohammed S. Al; Nsanze, H

doi:10.5144/0256-4947.2003.372

Cited by 15 publications

(13 citation statements)

References 9 publications

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“…However, the frequency of thyroid antibodies in Kuwaiti healthy individuals in our study was low compared with the 12.4% found by O'Leary et al [27] among Australians and 5.7% among Omanis reported by Al-Jabri et al [17] . The reason for these discrepancies can not be explained clearly, but it may be due to ethnic differences, and unknown genetic or environmental factors.…”

Section: Discussioncontrasting

confidence: 53%

“…There have been no detailed reports in the literature on the frequency of abnormal thyroid function tests and the presence of thyroid autoantibodies in healthy Kuwaitis or in those with autoimmune diseases other than our previous short report limited to the prevalence of hypothyroidism in patients with RA [16] , but there are detailed reports on other Arabs [17,18] . Therefore, the present study was designed to investigate the frequency of abnormal thyroid function tests in healthy Kuwaiti Arabs and in those with RA, SLE, and pSS.…”

Section: Introductionmentioning

confidence: 98%

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Frequency of Abnormal Thyroid Function Tests in Kuwaiti Arabs with Autoimmune Diseases

Al-Awadhi

Olusi²,

Hasan³

et al. 2008

Med Princ Pract

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Objectives: The purpose of this study was to examine the frequencies of abnormal thyroid function tests and serum thyroid autoantibodies in healthy Kuwaitis and those with autoimmune diseases. Subjects and Methods: Serum concentrations of sensitive thyrotropin, and free thyroxine were measured in 577 apparently healthy controls, 177 patients with rheumatoid arthritis (RA), 60 with systemic lupus erythematosus (SLE) and 25 with primary Sjogren’s syndrome (pSS) using the immunochemiluminescent assay method on IMMULITE 1000. Serum microsomal and thyroglobulin autoantibodies were also measured by passive hemagglutination assay. For analysis of the thyroid function tests, the subjects were classified into five categories: normal, subclinical hypothyroidism, overt hypothyroidism, euthyroid sick syndrome and biochemical hyperthyroidism. Results: Subclinical hypothyroidism was seen in 1.7% of healthy controls, 10.2% of RA, 13.3% of SLE, and 16% of pSS patients. Among RA patients, the frequency of subclinical hypothyroidism in females (11.4%) was significantly higher than among males (5.4%; p < 0.01). In SLE and pSS patients, all those with subclinical hypothyroidism were females. Overt hypothyroidism was seen in 1.4% of controls, 10.2% of RA, 8.3% of SLE, and 4% of pSS patients. Biochemical hyperthyroidism was seen in 0.2% of controls, 4.5% of RA, 5% of SLE and none of pSS patients. The euthyroid sick syndrome was seen in 0.4% of controls, 13.6% of RA, 16.7% of SLE and in none of pSS patients. Thyroid autoantibodies were present in 3.1% of controls, 12.4% of RA, 18.3% of SLE, and 12% of pSS patients. Conclusion: Our data show that abnormal thyroid function tests and thyroid autoantibodies occur frequently in Ku-waitis with autoimmune diseases. Therefore, ordering these tests in these diseases is recommended.

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Section: Discussioncontrasting

confidence: 53%

Section: Introductionmentioning

confidence: 98%

Frequency of Abnormal Thyroid Function Tests in Kuwaiti Arabs with Autoimmune Diseases

Al-Awadhi

Olusi²,

Hasan³

et al. 2008

Med Princ Pract

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“…Investigation of ANA seroprevalences is important, not only in the identification of autoimmune diseases in societies, but also in revealing subclinical conditions prior to disease, guiding early treatment and monitoring and in establishing the risk factors for these diseases (2). ANA seroprevalences between 4.2% and 22.6% have been reported for different societies (3)(4)(5)(6)(7)(8)(9). However, there are insufficient data regarding the ANA seroprevalence for the Eastern Black Sea region of Turkey, which includes the province of Trabzon, as well as for other regions of the country.…”

mentioning

confidence: 99%

Determination of Anti-Nuclear Antibody Seroprevalence in Adult Age Groups in Trabzon Province

Kaklıkkaya¹,

Akıneden²,

Topbaş³

et al. 2013

Balkan Med J

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“…4% to 13% 20,21,22,23 . ANA has been reported as 7.6% in Omani population 24 and 4.2% in Saudi Arabian population 20 . Baig and Shere (1989) also suggested ANA as four-fold more prevalent in females than in males in Saudi Arabian population, whereas in the current study, there was no difference of ANA between healthy male and females.…”

Section: Discussionmentioning

confidence: 99%

“…It should be noted that RF a-Abs are frequently present in healthy subjects and can be detected in chronic infections. It have been suggested that RF may have a protective or regulatory role in the immune system 24 . In the current study, 7.4% subjects had anti dsDNA that is higher than 3.3% documented in the Omani population 26 .…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Autoantibodies in Healthy Adults in Pakistani Population

Ashraf

Afzal

Kashif

et al. 2016

Bangladesh J Med Sci

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Introduction: Autoimmune phenomenon is attributed to a number of diseases which were once considered idiopathic. In humans, production of auto antibodies (a-Abs) against self-antigens is quite frequent but earlier their presence was associated with autoimmune diseases, however a-Abs have been documented in non-autoimmune disorders i.e. complicated pregnancy, cancer, stroke etc. In Pakistan, limited data is available on frequency of a-Abs, therefore this study was designed to determine serum level of antinuclear antibody (ANA), Rheumatoid factor (RF) and anti dsDNA antibodies in apparently healthy population. Materials and methods: After written informed consent, blood sample of 256 subjects was obtained by random sampling. Participants of established autoimmune diseases were excluded. Enzyme linked immunosorbent assay (ELISA) was used to determine ANA, RF and anti-dsDNA antibody. Categorical variables were compared by using χ 2 test. A p value <0.05 was considered statistically significant. Results: Rheumatoid factor was the most frequent a-Ab (18%), followed by anti dsDNA (7.4%), while ANA was the lowest (0.4%) antibody detected. Only RF had a statistically significant association with gender (p=0.047). No association of these antibodies with age was detected. Conclusion: Rheumatoid factor auto antibody was more prevalent as compared to ANA and dsDNA antibody in healthy adults.

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Frequency and Levels of Autoantibodies in Healthy Adult Omanis

Cited by 15 publications

References 9 publications

Frequency of Abnormal Thyroid Function Tests in Kuwaiti Arabs with Autoimmune Diseases

Frequency of Abnormal Thyroid Function Tests in Kuwaiti Arabs with Autoimmune Diseases

Determination of Anti-Nuclear Antibody Seroprevalence in Adult Age Groups in Trabzon Province

Prevalence of Autoantibodies in Healthy Adults in Pakistani Population

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