The paper represents the research results as for the factors of such dangerous geological phenomenon as landslides in terms of geological medium of the city of Dnipro. It is emphasized that there are certain geological, geomorphological, and hydrogeological conditions favouring the development of a medium for landslide formation. Irrespective of long-term study of that phenomenon, spatiotemporal prognosis is a complex scientific problem requiring application of innovative ideas and scientific statements concerning both separate components of a geological medium and rather complex natural and technogenic system. The paper analyzes conditions of the development of deep landslides within the territory of the city of Dnipro connected with a geological structure in a scope going beyond traditional scope of engineering and geological studies. Despite wide occurrence of landslide developments within the territory of the region, landslide of the Dnipro region are not singled out as a separate regional type. According to different estimations, general number of landslides is more than 144 within the city of Dnipro. The studies are based on numerous calculations of slope stability indicating the importance of the occurrence of Pre-Quaternary deposits as the factor favour- ing deep landslide formations. Basing upon the processing of the geological studies, cartographic modeling of the surfaces of certain levels, their thickness, and analysis of landslides grouping within the areas of singled-out territories have been performed. Maps of the surfaces of reddish-brown (N2-Q1) and grey-green (N1-S2) clays as well as deposits of Obukhivska (P2ob) and Mezhyhirska (P3 mž) suites, representing together the rock thickness corresponding to Kharkiv Stage (P2-3hr), have been developed. It has been proved that occurrence mode of clays at the base of loessial soils creates certain conditions for the development of landslides being different in their mechanisms (i.e. cutting, slipping, and squeezing). An example of certain calculations of slope stability is given confirming the important role of argillaceous rocks in the formation of the zone of changed soil condition and property. It has been proved that occur- rence mode of the rocks occurring lower than the depth of water erosion development should be studied thoroughly while designing landslide protection structures to obtain accurate model of the geological medium.