Frequency and morphological study of testicular germ cell tumor.

Abstract

Objectives: To assess the frequency of various histopathological types of testicular germ cell tumor in our study population. The prime identification of testicular germ cell tumor is important to prevent the advance stage of cancers. The present study was design to assess the frequency of different morphological types of testicular germ cell tumor which have a mirror effect on the treatment and prognosis of tumor. Study Design: Cross sectional study. Setting: Department of pathology, Basic Medical Sciences Institute, Jinnah Postgraduate Medical Centre Karachi. Period: 10 years period from 1st January 2006 to 31st December 2015. Material and Methods: A 34 cases of testicular germ cell tumor were studied for morphological features using all properly formalin fixed, paraffin embedded surgical pathological testicular specimens received during the above period. All relevant clinical information was recorded on designed proformas. Section were taken and stained with hematoxylin and eosin. Data entered and analysed through computer software SPSS version 21. Results: The result of study showed that the frequency of testicular germ cell tumor was 0.80% among all malignancy in male. Out of 36 cases of testicular tumor, 34 (94.5%) were germ cell tumors and remaining 02 (5.5%) cases were sex cord stromal tumor. Among 34 cases of germ cell tumor 12 (35.2%) cases of mixed germ cell tumor found which was the most common between them, followed by seminoma 10 (29.4%) cases. However 05(14.7%) of yolk sac tumor, 04 (11.6%) of teratoma and 03(8.8%) of embryonal tumor were found. Conclusion: Results revealed that frequency of different types of testicular germ cell tumor in this study were in accordance to national and international studies. However the incidence of tumor varies noticeably in different geographical areas. Different pattern of seminomas and non – seminomas also may be emerging.

Testiküler Seminomatöz ve Nonseminomatöz Germ Hücreli Tümörler: Klinik ve Patolojik Özelliklerinin Karşılaştırılması

“…MGCTs are the most commonly seen group among NSE-GCTs and they demonstrate the morphological combinations of EC+TE, EC+SEM or EC+YST while they may have any morphological combination; they commonly include more than 2 components (7). It has been shown in some studies that MGCT is the most frequently seen subtype among NSE-GCTs (1,13,16). Consistently with the literature, 51% and 49% of our cases were in the SEM and NSE-GCT groups, respectively, and 69.2% of the NSE-GCTs revealed the morphology of MGCT.…”

“…Without subgroup discrimination, no patient below 15 years and over 60 years of age was present also in our case series and NSE-GCT was detected at one-decade earlier age compared with SEM consistently with the literature. It has been shown in the studies that their incidence has increased in the recent half century because of lifestyle changes (11) and varies between racial/ethnic groups (5,10,12,13). The incidence of germ cell tumors in the Scandinavian and European countries is higher compared with the Asian and African countries.…”