Frequency and risk factors in bronchopulmonary dysplasia in a cohort of very low birth weight infants

Korhonen, Päivi; Tammela, Outi; Am, Koivisto; Laippala, Pekka; Ikonen, Sami

doi:10.1016/s0378-3782(98)00101-7

Cited by 96 publications

(74 citation statements)

References 24 publications

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“…The literature review found seven similar studies (6)(7)(8)(9)(10)(11)(12). These are summarized in Table 3.…”

Section: Resultsmentioning

confidence: 96%

“…In one study, the cohort was born before 1991 and BPD was determined at 28 days only (12). In another study of infants <1,501 g birth weight from a single hospital, it was not possible to reconstruct data for the outcome of BPD at 36 wks' PMA, although there was a nonsignificant reduction in the risk of BPD at 28 days in those whose mothers had PE (risk ratio 0.71; 95% CI 0.39, 1.27) (10). One study was excluded because it was a casecontrol study and not a cohort study (9); in this study, there was a nonsignificant reduction in the odds of BPD with exposure to PE (OR 0.89, 95% CI 0.28, 2.81).…”

Section: Resultsmentioning

confidence: 99%

“…The previous studies are either single-centered (8)(9)(10)(11)(12) or multicentered (6,7), but none is based on a geographical cohort. A weakness of our study is that we cannot be certain about the biochemical abnormalities that led to a diagnosis of PE in the mother, but we do know it had to be severe enough to lead to early delivery.…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have examined the relationship between intrauterine exposure to maternal PE and the risk of the infant developing BPD (6)(7)(8)(9)(10)(11)(12). Some of these report that PE is protective and reduces the incidence of BPD (9,10,12).…”

mentioning

confidence: 99%

“…Some of these report that PE is protective and reduces the incidence of BPD (9,10,12). Others report that PE is associated with an increased incidence of BPD (7,8).…”

mentioning

confidence: 99%

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Maternal preeclampsia and risk of bronchopulmonary dysplasia in preterm infants

2011

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INTRODUCTION:To better understand whether preeclampsia (Pe) increases the risk of bronchopulmonary dysplasia (BPD). RESULTS: Of 753 infants alive at 36 wks, 138 (18.3%) were exposed to Pe. BPD was not significantly related to exposure to Pe either before (odds ratio (OR) 0.73; 95% confidence interval (cI) 0.50, 1.06) or after adjustment for confounding variables (adjusted OR 1.14; 95% cI 0.71, 1.81). If infants were selected by gestational age alone, there was no association (OR 1.05; 95% cI 0.63, 1.75). In contrast, selecting by birth weight alone, Pe was associated with a significant reduction in BPD (OR 0.61, 95% cI 0.41, 0.91). however, this effect disappeared after adjustment for confounding variables. DISCUSSION: conclusions were unchanged when data from other studies were included in a pooled analysis. Pe does not significantly affect the risk of BPD in extremely preterm (eP) or extremely-low-birth-weight (eLBW) subjects. METHODS:We examined data on eP (<28 wks gestation) or eLBW (<1,000 g) infants live born in Victoria, australia, in three eras: 1991Victoria, australia, in three eras: -1992Victoria, australia, in three eras: , 1997Victoria, australia, in three eras: , and 2005. We compared the incidence of BPD (oxygen requirement at 36 wks' postmenstrual age) in the Pe group (infants exposed to Pe) with that in the remainder (nonexposed infants). We also contrasted results with comparable reported studies.

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“…The literature review found seven similar studies (6)(7)(8)(9)(10)(11)(12). These are summarized in Table 3.…”

Section: Resultsmentioning

confidence: 96%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

“…Some of these report that PE is protective and reduces the incidence of BPD (9,10,12). Others report that PE is associated with an increased incidence of BPD (7,8).…”

mentioning

confidence: 99%

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Maternal preeclampsia and risk of bronchopulmonary dysplasia in preterm infants

2011

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Clinical Outcomes Following Institution of Universal Leukoreduction of Blood Transfusions for Premature Infants

Fergusson

Hébert²,

Lee³

et al. 2003

JAMA

110

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Context Leukocytes present in stored blood products can have a variety of biological effects, including depression of immune function, thereby increasing nosocomial infections and possibly resulting in organ failure and death. Premature infants, given their immature immune state, may be uniquely predisposed to the effects of transfused leukocytes. Objective To evaluate the clinical outcomes following implementation of a universal prestorage red blood cell (RBC) leukoreduction program in premature infants admitted to neonatal intensive care units (NICUs). Design and Setting Retrospective before-and-after study conducted in 3 Canadian tertiary care NICUs from January 1998 to December 2000. Patients A total of 515 premature infants weighing less than 1250 g who were admitted to the NICU, received at least 1 RBC transfusion, and survived at least 48 hours were enrolled. The intervention group consisted of infants admitted in the 18-month period following the introduction of universal leukoreduction (n=247) and the control group consisted of infants admitted during the 18 months prior to the introduction of universal leukoreduction (n=268). Main Outcome Measures Primary outcomes were nosocomial bacteremia and NICU mortality, compared before and after implementation of universal leukoreduction using multivariate regression. Secondary outcomes included bronchopulmonary dysplasia, retinopathy of prematurity, necrotizing enterocolitis, and intraventricular hemorrhage. Results The proportion of infants who acquired bacteremia after an RBC transfusion was 79/267 (29.6%) in the nonleukoreduction period and 63/246 (25.6%) in the leukoreduction period. For NICU mortality, there were 45 deaths (16.8%) in the nonleukoreduction period and 44 deaths (17.8%) in the leukoreduction period. The adjusted odds ratio (OR) for bacteremia was 0.59 (95% confidence interval [CI], 0.34-1.01) and for mortality was 1.22 (95% CI, 0.59-2.50). The adjusted ORs for bronchopulmonary dysplasia and retinopathy of prematurity were 0.42 (95% CI, 0.25-0.70) and 0.56 (95% CI, 0.33-0.93), respectively. The adjusted ORs for necrotizing enterocolitis and grade 3 or 4 intraventricular hemorrhage were 0.39 (95% CI, 0.17-0.90) and 0.65 (95% CI, 0.35-1.19), respectively. The adjusted OR for a composite measure of any major neonatal morbidity was 0.31 (95% CI, 0.17-0.56). Crude and adjusted rates for all secondary outcomes suggest that leukoreduction was associated with improved outcomes. Conclusion Implementation of universal prestorage leukoreduction was not associated with significant reductions in NICU mortality or bacteremia but was associated with improvement in several clinical outcomes in premature infants requiring RBC transfusions.

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Is Leukoreduction of Blood Components for Everyone?

Corwin¹,

AuBuchon²

2003

JAMA

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Frequency and risk factors in bronchopulmonary dysplasia in a cohort of very low birth weight infants

Cited by 96 publications

References 24 publications

Maternal preeclampsia and risk of bronchopulmonary dysplasia in preterm infants

Maternal preeclampsia and risk of bronchopulmonary dysplasia in preterm infants

Clinical Outcomes Following Institution of Universal Leukoreduction of Blood Transfusions for Premature Infants

Is Leukoreduction of Blood Components for Everyone?

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