Frequency and Risk Factors of Kidney Alterations in Children and Adolescents who Are Overweight and Obese in a Primary Health-care Setting

Martín-del-Campo, Fabiola; Batis, Carolina; Ordaz-Medina, Susan M.; Martínez-Ramírez, Héctor R.; Vizmanos-Lamotte, Barbara; Romero‐Velarde, Enrique; Cortés-Sanabria, Laura; Cueto-Manzano, Alfonso M.

doi:10.1053/j.jrn.2018.11.005

Cited by 5 publications

(4 citation statements)

References 29 publications

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“…We here showed that SCr values of children with overweight and obesity are within the reference range. While some studies have demonstrated similar SCr values between children with lean weight and overweight or obesity [32][33][34][35], in other studies [36,37], SCr values were higher in children with overweight or obesity compared to lean controls. It is not excluded that these inconsistent results are due to confounding factors such as age, height, and sex and/or due to the heterogeneity of the methods for SCr measurements.…”

Section: Discussionmentioning

confidence: 96%

Creatinine-based GFR-estimating equations in children with overweight and obesity

2022

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Background With the increasing prevalence of childhood obesity and related development of chronic kidney disease (CKD), there is a critical need to understand how best to assess kidney function in children with obesity. Since serum creatinine (SCr) is recommended as marker of first choice for GFR estimation, we evaluated and compared creatinine-based GFR equations in children with overweight and obesity. Methods Six hundred children with overweight and obesity (53.5% female; mean age 12.20 ± 3.28 years; mean BMI z-score 3.31 ± 0.75) were included from the Centre for Overweight Adolescent and Children’s Healthcare (COACH). Results Serum creatinine (SCr), normalized using Q-age polynomials obtained from reference values, results in median and mean SCr/Q value close to “1” for all age groups, and 96.5% of the children have a SCr/Q within the reference band [0.67–1.33], corresponding to the 2.5th and 97.5th percentile. eGFR CKiD (bedside Schwartz equation) and Schwartz-Lyon decreased with age, whereas eGFR EKFC and modified CKD-EPI40 showed no age-dependency, but the distribution of eGFR values was not symmetrical. eGFR CKiD under 25 (CKiDU25) demonstrated no age-dependency but major sex differences were observed. eGFR FAS age, FAS height, and adjusted-creatinine revised Lund-Malmö (LMR18) showed a relatively symmetrical distribution and no age-dependency. Conclusions Serum creatinine (SCr) values of children with overweight and obesity are mostly within the reference range for children. Normalization of SCr using reference Q-age polynomials works very well in this cohort. After evaluation of the different equations, we suggest that FAS age, FAS height, and LMR18 are the preferred creatinine-based GFR-estimating equations in children with overweight and obesity. Clinical trial registration. ClinicalTrial.gov; Registration Number: NCT02091544. Graphical abstract A higher resolution version of the Graphical abstract is available as Supplementary information

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Section: Discussionmentioning

confidence: 96%

Creatinine-based GFR-estimating equations in children with overweight and obesity

2022

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“…In a study by Martin-Del-Campo et al [ 38 ] subjects with kidney alterations had higher body fat markers (including body mass index, waist circumference, fat percentage, subscapular skinfold, etc. ) values and lower high-density lipoprotein cholesterol levels.…”

Section: What Is the State Of Art Of Ma In Children With Obesity?mentioning

confidence: 99%

Tangled relationship between insulin resistance and microalbuminuria in children with obesity

Colasante¹,

Bartiromo²,

Nardolillo³

et al. 2022

World J Clin Pediatr

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Childhood obesity represents a complex disease with a well-known cardiometabolic burden including fatty liver, type 2 diabetes, metabolic syndrome, and cardiovascular disease. From a pathogenic point of view, insulin resistance (IR) represents the key factor underlying the spectrum of these obesity consequences. As observed in adults, recent data supported the occurrence of microalbuminuria (MA) as marker of early kidney dysfunction and its potential link with cardiometabolic factors also in children with obesity. In fact, a well-documented pathophysiological hypothesis both in adults and children supported an intimate correlation with the major feature of obesity such as IR through the influence of insulin on renal hemodynamics. Based on the clinical and prognostic relevance of this relationship in daily practice (including an increased risk of chronic kidney disease development overtime), more scientific attention needs to be paid to the evaluation of early kidney damage in children with obesity. In this paper, we attempt to address three debated questions regarding the intriguing liaison between IR and MA in children with obesity: (1) What is the prevalence of pediatric MA? (2) What is the state of art of MA in children with obesity? and (3) Is there a link between IR and MA in children with obesity?

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“…Although the 3 aforementioned studies by Martin-del-Campo et al 15 , Song et al, 16 and Yong et al 17 imply the potential impact of nutritional status including certain nutrient intakes on CKD risk and on disease progression, i.e., primary and secondary prevention of CKD, in the nested case-control study by Abbasi et al, 18 also published in this issue of JREN, there was no significant association of total antioxidant capacity of the food or total dietary energy intake with prevalence of CKD in persons with type 2 diabetes. It is possible that dietary factors relevant to patients with diabetes and no CKD, such as higher dietary energy intake, are less relevant to patients with CKD and diabetes, and that dietary protein intake is a more relevant dietary target as shown recently, although the latter was not examined in this study.…”

mentioning

confidence: 98%

“…In this issue of the JREN, Martin-del-Campo et al 15 examined the association of obesity with kidney disease in 172 children and adolescents and found that renal hyperfiltration (defined as estimated glomerular filtration rate .170 mL/min/1.73 m 2 ) and microalbuminuria were present in children and adolescents with overweight and obesity, whereas those considered at normal weight exhibited no kidney alterations. Hence, better nutritional management of children to prevent or correct obesity may have an impact on overall kidney health across the population.…”

mentioning

confidence: 99%

Implementing the “Advancing American Kidney Health Initiative” by Leveraging Nutritional and Dietary Management of Kidney Patients

Moore

Kalantar-Zadeh

2019

Journal of Renal Nutrition

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Frequency and Risk Factors of Kidney Alterations in Children and Adolescents who Are Overweight and Obese in a Primary Health-care Setting

Cited by 5 publications

References 29 publications

Creatinine-based GFR-estimating equations in children with overweight and obesity

Creatinine-based GFR-estimating equations in children with overweight and obesity

Tangled relationship between insulin resistance and microalbuminuria in children with obesity

Implementing the “Advancing American Kidney Health Initiative” by Leveraging Nutritional and Dietary Management of Kidney Patients

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