Frequency and Significance of the Major and Minor Features of Hanifin and Rajka among Patients with Atopic Dermatitis

Abstract

In 481 patients with atopic dermatitis (AD), 4 major features of Hanifin and Rajka were found in 72%, and in 96% over 6 minor features were seen, which is much more than the minimum required by these authors for making a ‘firm diagnosis’. The incidence of particular minor features in all patients was varying significantly, and in subgroups of patients they appeared with different frequency. For example, asthma occurred more often in AD patients with the onset of skin lesions before the 6th month of life, and food intolerance was more frequently observed in patients with very high serum IgE level. In the control groups some minor features also occur but less frequently than in AD patients. We conclude that the anterior neck folds and Dennie-Morgan infraorbital fold should be regarded as minor AD features.

Stratum Corneum Tape Stripping: Monitoring of Inflammatory Mediators in Atopic Dermatitis Patients Using Topical Therapy

“…Ninety adult patients from the VU Medical Center Amsterdam outpatient clinic (average age 33 years; 57 females, 33 males) with AD as defined by the Hanifin and Rajka criteria entered the study after their written informed consent had been obtained [18]. Only patients with mild-to-moderate AD based on the OSCORAD (Objective SCORing AD) score (range 12.5-50) were included [19,20].…”

DJ-1 regulates mast cell activation and IgE-mediated allergic responses

“…They fulfilled the criteria of Hanifin and Rajka. 23 The patients had been suffering from wide range of AD severity with a SCORAD index of 35.0 ± 19.8 (22 mild, 17 moderate, and 17 severe patients) at the time of study (Table E1 in this article’s Online Repository at www.jacionline.org). 24 All medications were discontinued for at least two weeks before the study although topical application of hydrocortisone 1% was allowed.…”

Guidelines of care for the management of atopic dermatitis

“…11 While comprehensive and often utilized in clinical trials, such a large number of criteria are unwieldy for use in clinical practice. Some of the minor criteria have been noted to be poorly defined or non-specific (such as pityriasis alba), while others, such as upper lip cheilitis and nipple eczema, are quite specific for AD but uncommon.…”

“…Some of the minor criteria have been noted to be poorly defined or non-specific (such as pityriasis alba), while others, such as upper lip cheilitis and nipple eczema, are quite specific for AD but uncommon. 11, 12 Several international groups proposed modifications to address these limitations (e.g. Kang and Tian criteria, International Study of Asthma and Allergies in Childhood (ISAAC) criteria).…”