Frequency and specificity of Red blood cell alloantibodies in multitransfused Egyptian patients with hematological and nonhematological malignancies

Fetouh, Randa M. Abo El; Elmoniem, Gamal M. Abd; Allam, Rasha Mahmoud; Sobeih, Mohamed Emam; Kamel, Mahmoud M.; Radwan, Samah

doi:10.1016/j.transci.2020.102909

Cited by 6 publications

(2 citation statements)

References 34 publications

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“…"The finding is lower and at variance with previous findings that reported frequency of alloimmunization to be 18.7 % among the previously transfused and 5 % in all sickle cell disease patients with a specificity of 46.7 % Rhesus, 40 % Kell, while Lutheran and Duffy 13.3 %, each as well as auto-antibodies in 1.25 %" [16]. It is also at variance with the report of El Fetouh and colleagues who reported prevalence of different alloantibodies as 9.16% with some having more than 1 antibody detected in a patient with haematological malignancies at Egypt with f alloantibodies specificity as the Rh system [45.3% with specificity of anti-E (21.3%) and anti-D (6.4%), anti-C (9.4%) and anti-c (8.2%)], followed by Kell (25.1%), Duffy (13.9%), MNS (7.5%), Kidd (7.1%), and Lewis (1.1%) [17]. It is also at variance with the report of Hussein and colleagues who recorded alloimmunization incidence as 22.8% with 37.4% Rh-related alloantibody followed by 26% anti-Kell, 8.9% anti-MNS 8.9% anti-Kidd, 8.1% anti-Duffy, 5.7% anti-Le, 2.4% anti-Lu and 1.6% anti-P1 [18].…”

Section: Resultsmentioning

confidence: 99%

Distribution of Maternal Red Cell Antibodies and the Risk of Haemolytic Disease of the Foetus and Newborn in Sokoto Nigeria

Buhari

Sagir²,

Akuyam³

et al. 2022

JOCAMR

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Background: The incidence is still of clinical importance because sensitization of the mother may occur through the placenta, blood transfusion, miscarriage, ectopic pregnancy, amniocentesis as well as lack of prophylaxis of alloantibody except RhD. Aim: The aim of this study is to determine the prevalence of clinically significant red blood cell alloantibodies among pregnant women. Study Design: This was a cross- sectional study. Duration of Study: The study lasted for a period of one year between January to December, 2021. Methodology: About 1250 consecutively recruited pregnant women were screened for alloantibody and identification was done to determine the specificity of the antibody using NHSBT reagent with column agglutination card technology. Results: Among the 1250 apparently healthy pregnant women studied, 73(5.8%) had alloantibodies with specificity as follows: Multiple antibody of C, E 3 (4.1%), D 23 (31.5%), C 6(8.2%), E 5(6.8%), e (1.4%), Jka 2 (2.7%), Jkb 2 (2.7), M 1 (1.4%), S 1 (1.4%), Lea 7 (9.6%), Leb 8 (11%), I 4 (5.5%), and Lu 7 (9.6%). When the demographic and obstetric characteristics were compared with the presence of alloantibodies, statistically significant differences were observed in gestational age, past history of pregnancy, preeclampsia, and previous baby delivered with jaundice and previous administration of anti-D prophylaxis. Conclusion: There is high prevalence of alloantibody among pregnant women that may be linked to lack of premarital testing to know couple at risk and lack of standard protocol of alloantibody testing.

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Section: Resultsmentioning

confidence: 99%

Distribution of Maternal Red Cell Antibodies and the Risk of Haemolytic Disease of the Foetus and Newborn in Sokoto Nigeria

Buhari

Sagir²,

Akuyam³

et al. 2022

JOCAMR

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“…Patients with sickle cell disease are more at risk of developing alloimmunisation, which makes cross-matching and suitable blood for transfusions problematic when the issues of minor antigens are not considered during the transfusion [ 58 , 119 ]. According to Boateng et al [ 123 ], the frequency of alloantibody development in patients with SCD is as high as 76% compared to the general population [ 124 ]. The frequency of red blood cell alloimmunisation in SCD patients may not be the same in every part of the world due to blood transfusion rates, ethnic mismatch, and the age of the initial transfusion [ 20 , 125 , 126 ].…”

Section: The Cause Of High Alloimmunisation In Scd Patientsmentioning

confidence: 99%

A Review of the Relationship between the Immune Response, Inflammation, Oxidative Stress, and the Pathogenesis of Sickle Cell Anaemia

Aboderin,

Oduola,

Davison

et al. 2023

Biomedicines

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Sickle cell anaemia (SCD) is a life-threatening haematological disorder which is predominant in sub-Saharan Africa and is triggered by a genetic mutation of the β-chain haemoglobin gene resulting in the substitution of glutamic acid with valine. This mutation leads to the production of an abnormal haemoglobin molecule called haemoglobin S (HbS). When deoxygenated, haemoglobin S (HbS) polymerises and results in a sickle-shaped red blood cell which is rigid and has a significantly shortened life span. Various reports have shown a strong link between oxidative stress, inflammation, the immune response, and the pathogenesis of sickle cell disease. The consequence of these processes leads to the development of vasculopathy (disease of the blood vessels) and several other complications. The role of the immune system, particularly the innate immune system, in the pathogenesis of SCD has become increasingly clear in recent years of research; however, little is known about the roles of the adaptive immune system in this disease. This review examines the interaction between the immune system, inflammation, oxidative stress, blood transfusion, and their effects on the pathogenesis of sickle cell anaemia.

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Risk factors for red blood cell alloimmunization in patients with hematologic malignancy

Pattarakosol,

Lorucharoen,

Watanaboonyongcharoen

et al. 2024

Transfusion Medicine

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IntroductionPatients with hematologic malignancy have a higher risk of developing red blood cell (RBC) alloimmunization which can delay blood transfusion. Information on the risk factors for alloimmunization in this group is still limited. This study aimed to determine the prevalence and predictors of RBC alloimmunization among these patients.Materials and MethodsElectronic medical records of the patients with acute myeloid leukaemia (AML), acute lymphoid leukaemia (ALL), multiple myeloma (MM) and lymphoma from a tertiary care hospital between January 2018 and December 2022 were retrospectively reviewed. Clinical, demographic and transfusion history data of the included patients were analysed.ResultsOf the 983 patients with hematologic malignancy, 798 were included in the study. The prevalence of RBC alloantibodies in this population was 4.8% (38 patients). The alloimmunization rate of each subgroup was as followed: AML 9.1%, ALL 2.9%, MM 3.8% and lymphoma 2.5%. The most common alloantibodies were anti‐Mia, anti‐E and anti‐Lea. The majority (29/38, 76.3%) of alloimmunization had a single alloantibody. RBC autoantibody was detected in 10 patients. The detection of autoantibodies and having AML were independently associated with RBC alloimmunization (adjusted odds ratio [aOR] 13.41, 95% confidence interval [CI] 2.00–89.72, p = 0.007 and aOR 11.44, 95% CI 2.02–64.72, p = 0.006, respectively).ConclusionThe prevalence of RBC alloimmunization in the patients with hematologic malignancy was 4.8%. The alloimmunization rate of the AML subgroup was higher than those of other hematologic malignancies. The detection of autoantibodies and the AML diagnosis were identified as potential risk factors for RBC alloimmunization.

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Frequency and specificity of Red blood cell alloantibodies in multitransfused Egyptian patients with hematological and nonhematological malignancies

Cited by 6 publications

References 34 publications

Distribution of Maternal Red Cell Antibodies and the Risk of Haemolytic Disease of the Foetus and Newborn in Sokoto Nigeria

Distribution of Maternal Red Cell Antibodies and the Risk of Haemolytic Disease of the Foetus and Newborn in Sokoto Nigeria

A Review of the Relationship between the Immune Response, Inflammation, Oxidative Stress, and the Pathogenesis of Sickle Cell Anaemia

Risk factors for red blood cell alloimmunization in patients with hematologic malignancy

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