Frequency and topography of small cerebrovascular lesions in vascular and in mixed dementia: a post-mortem 7-tesla magnetic resonance imaging study with neuropathological correlates

Reuck, Jacques L. De; Auger, F.; Durieux, Nicolas; Deramecourt, Vincent; Maurage, Claude‐Alain; Cordonnier, Charlotte; Pasquier, Florence; Leys, Didier; Bordet, Régis

doi:10.5114/fn.2017.66711

Cited by 10 publications

(5 citation statements)

References 27 publications

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“…The increase of CAA with age is the leading cause of mixed AD group in elderly patients, leading to more frequent cerebral infarcts and lobar haematomas [10,14,[16][17][18]21,24].…”

Section: Discussionmentioning

confidence: 99%

Aging and cerebrovascular lesions in pure and in mixed neurodegenerative and vascular dementia brains: a neuropathological study

Reuck¹,

Maurage²,

Deramecourt³

et al. 2018

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Introduction: The prevalence of dementia is increasing in our aging population. Because of the complexity of disease pathology, dementia classifications remain controversial. The present post-mortem study investigates whether there are age differences between dementia brains with a single pure neurodegenerative or cerebrovascular disease and those with mixed pathological features. Also, the impact of these vascular lesions is compared. Material and methods: A total of 132 dementia brains with a pure neurodegenerative or cerebrovascular disease and 84 with mixed features were examined. Main age and gender distribution were compared between the overall group of pure and of mixed dementia. Also, the most common subgroups were compared separately. In addition to the detection of macroscopic visible lesions, a whole coronal section of a cerebral hemisphere, at the level of the mamillary body, was taken for semi-quantitative microscopic evaluation of white matter changes (WMCs), cortical micro-bleeds (CoMBs), and cortical micro-infarcts (CoMIs). Results: Overall, patients with mixed dementia were at death significantly older than those with pure dementia. According to the main diagnosis, the pure forms of Alzheimer's disease (AD) and frontotemporal lobar degeneration (FTLD) were more common in the younger age groups while in the older ones the mixed form of Lewy body disease (LBD) predominated. Neuropathological examination revealed an increased severity of cerebral amyloid angiopathy (CAA), territorial infarcts, lobar haematomas, and CoMIs in the mixed AD group. In FTLD only CoMIs were increased in the mixed group, while in LBD no differences in severity of all cerebrovascular lesions were observed. Lacunar infarcts were more frequent in pure vascular dementia, while CAA predominated in the mixed one. Conclusions: Mixed dementia during the aging process is mainly due to the severity of AD and LBD pathologies combined with CAA-related cerebrovascular lesions.

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“…The increase of CAA with age is the leading cause of mixed AD group in elderly patients, leading to more frequent cerebral infarcts and lobar haematomas [10,14,[16][17][18]21,24].…”

Section: Discussionmentioning

confidence: 99%

Aging and cerebrovascular lesions in pure and in mixed neurodegenerative and vascular dementia brains: a neuropathological study

Reuck¹,

Maurage²,

Deramecourt³

et al. 2018

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“…On MRI Fe deposits are absent in cortical micro-infarcts ( Fig.5). On the other end, small areas of Fe deposits reflecting the hemoglobin accumulation are the hallmarks of cortical microbleeds ( Fig.6) [29].…”

Section: Resultsmentioning

confidence: 99%

Iron Deposition in Cerebrovascular Diseases: A Post-Mortem Review

Reuck¹

2019

IJNP

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“…24 CoMIs predominate in the occipital lobes in mixed dementias compared to their prevalent location in the frontal lobes and cerebellum of CAA-related VAD brains. 25 Cerebellar CoMIs are in contrast to cerebral ones not related to CAA, but mainly due to arteriosclerotic cerebrovascular disease in VAD as well as in the different neurodegenerative diseases. 26…”

Section: Cortical Micro-infarctsmentioning

confidence: 99%

Significance of Cortical Micro-Infarcts in the Human Brain

Reuck¹

2021

SOJNN

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Cortical micro-infarcts are due to cerebral small vessel disease. In contrast to the arteriosclerotic type of cerebral small vessel disease, cortical micro-infarcts are mainly related and due to cerebral amyloid angiopathy. Alzheimer’s disease is the most frequent neurodegenerative dementia disease associated to cerebral amyloid angiopathy and cortical micro-infarcts. Vascular dementia cannot only be due to lacunar infarcts and ischemic white matter changes, but can also be caused by cortical micro-infarcts. The latter are a frequent cause of vascular dementia and decrease globally the cerebral blood flow.

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Frequency and topography of small cerebrovascular lesions in vascular and in mixed dementia: a post-mortem 7-tesla magnetic resonance imaging study with neuropathological correlates

Abstract: A b s t r a c t Introduction: Mixed dementia (MixD) refers to a combination of definite Alzheimer's disease (AD) and vascular

Cited by 10 publications

References 27 publications

Aging and cerebrovascular lesions in pure and in mixed neurodegenerative and vascular dementia brains: a neuropathological study

Aging and cerebrovascular lesions in pure and in mixed neurodegenerative and vascular dementia brains: a neuropathological study

Iron Deposition in Cerebrovascular Diseases: A Post-Mortem Review

Significance of Cortical Micro-Infarcts in the Human Brain

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