Maintaining the accuracy of a sensor system across various operating conditions has always been a challenge, especially for those operating in harsh surroundings such as a radiation environment. Concerning frequency-based sensor interfaces, supply voltage drifts and gain shift of the voltage-to-frequency converter (VFC) are critical design issues. These manifest as gain, offset, and linearity errors at the system level and therefore require continuous correction mechanisms. In this paper, dynamic gain and offset error-compensated open-loop frequency-based sensor interface architectures with adaptive clock frequency are proposed, which result in a ratiometric digital output. To address the mismatch issue, two architectures, one with periodic swapping of the VFCs’ inputs and outputs, and the other with the use of a single analog-to-digital converter (ADC) as an analog front end, are developed. The concepts were demonstrated with implementations on a Zynq board (ZYBO). The results of the first architecture showed that for a 25% gain mismatch between the VFCs, the output gain error was reduced from around 7.4% to 0.79% and the offset error was reduced from around 11.8% to 0.01%. Additionally, for the second architecture, a maximum of 0.11% gain error and 0.1% offset error were recorded for an emulated ±25% supply drift.