Frequency components of systolic blood pressure variability reflect vasomotor and cardiac sympathetic functions in conscious rats

Yoshimoto, Takahiko; Eguchi, Kunihiro; Ohmichi, Yusuke; Hashimoto, Tatsuyuki; Ohmichi, Mika; Morimoto, Akihito; Yamaguchi, Yoshiko; Ushida, Takahiro; Iwase, Satoshi; Sugenoya, Junichi; Kumazawa, Takao

doi:10.1007/s12576-011-0158-7

Cited by 24 publications

(17 citation statements)

References 29 publications

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“…Evidence that LF‐BPV is an index of vascular sympathetic activity is more limited. In rats, phentolamine decreased midfrequency blood pressure variability, consistent with the hypothesis that it reflects α‐adrenergic‐mediated vasomotor function (Yoshimoto et al., ). Other blockade studies also support this view (Julien, Malpas, & Stauss, ; Stauss & Kregel, ; Stauss, Persson, Johnson, & Kregel, ; Zhang et al., ).…”

Section: Discussionsupporting

confidence: 81%

Effects of aerobic conditioning on cardiovascular sympathetic response to and recovery from challenge

et al. 2013

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Objective Exercise has widely-documented cardioprotective effects but the mechanisms behind these effects are still poorly understood. Here, we test the hypothesis that aerobic training lowers cardiovascular sympathetic responses to and speeds recovery from challenge. Methods We conducted a randomized controlled trial contrasting aerobic versus strength training on indices of cardiac (pre-ejection period, PEP) and vascular (low-frequency blood pressure variability, LF-BPV) sympathetic responses to and recovery from psychological and orthostatic challenge in 149 young, healthy and sedentary adults. Results Aerobic and strength training did not alter PEP or LF-BPV reactivity to or recovery from challenge. Conclusions These findings, from a large randomized controlled trial using an intent-to-treat design, show that moderate aerobic exercise training has no effect on PEP and LF BPV reactivity to or recovery from psychological or orthostatic challenge. In healthy young adults, the cardioprotective effects of exercise training are unlikely to be mediated by changes in sympathetic activity.

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Section: Discussionsupporting

confidence: 81%

Effects of aerobic conditioning on cardiovascular sympathetic response to and recovery from challenge

et al. 2013

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“…Recently, frequency components of SBP variability have been studied in conscious rats: mid-frequency and high frequency components may reflect -adrenoceptor-mediated vasomotor function and -adrenoceptor-mediated cardiac sympathetic function, respectively [64].…”

Section: Evidence For Altered Characteristics Of Blood Pressure Rhythmentioning

confidence: 99%

Circadian Rhythm of Blood Pressure in Diabetes Mellitus: Evidence, Mechanisms and Implications

Matteucci

Giampietro²

2012

CDR

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Circadian misalignment has been implicated in the development of diabetes mellitus and cardiovascular disease. Circadian rhythms of blood pressure (BP) and heart rate (HR) have long been known and the mechanisms controlling them have been actively investigated in physiology and disease. In this respect, the introduction of 24-hour ambulatory blood pressure monitoring (ABPM) has enabled a more accurate assessment of circadian BP patterns in order to solve diagnostic uncertainty or to establish dipper status. However, attention has been mainly focused on measures of extent (midline estimating statistic of rhythm, MESOR, and amplitude) rather than timing (acrophase) of changes within a cycle. The review summarises 1) evidence for altered characteristics of BP rhythm (in particular, phase shifts along the time axis) in animal and human diabetes mellitus, 2) the mechanisms that have been supposed to underlie the observed changes in cardiovascular function before diabetes onset and during progression of the disease, and 3) the adverse consequences that may result from an altered circadian BP rhythm.

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“…), and to impair baroreflex responsiveness (Yoshimoto et al. ). In contrast, surgical interventions are known to increase blood pressure and HR (Abraham et al.…”

Section: Introductionmentioning

confidence: 99%

“…Cardiovascular autonomic function is acutely challenged in the perioperative setting (Vinik and Ziegler 2007;Oakley and Emond 2011) by both anesthesia and surgical intervention. For instance, anesthesia is well known to lower blood pressure and heart rate (HR) (Altholtz et al 2006), and to impair baroreflex responsiveness (Yoshimoto et al 2011). In contrast, surgical interventions are known to increase blood pressure and HR (Abraham et al 1981;Gemes et al 2009;Charlet et al 2011;Yeh et al 2012).…”

Section: Introductionmentioning

confidence: 99%

Effect of type 2 diabetes, surgical incision, and volatile anesthesia on hemodynamics in the rat

Bussey

Lamberts

2017

Physiol Rep

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Diabetic patients have increased cardiac complications during surgery, possibly due to impaired autonomic regulation. Anesthesia lowers blood pressure and heart rate (HR), whereas surgical intervention has opposing effects. The interaction of anesthesia and surgical intervention on hemodynamics in diabetes is unknown, despite being a potential perioperative risk factor. We aimed to determine the effect of diabetes on the integrative interaction between hemodynamics, anesthesia, and surgical incision. Zucker type 2 diabetic rats (DM) and their nondiabetic littermates (ND) were implanted with an intravenous port for drug delivery, and a radiotelemeter to measure mean arterial blood pressure (MAP) and derive HR (total n = 50). Hemodynamic pharmacological responses were assessed under conscious, isoflurane anesthesia (~2–2.5%), and anesthesia–surgical conditions; the latter performed as a laparotomy. MAP was not different between groups under conscious conditions (ND 120 ± 6 vs. DM 131 ± 4 mmHg, P > 0.05). Anesthesia reduced MAP, but not differently in DM (ND −30 ± 6 vs. DM −38 ± 4 ΔmmHg, P > 0.05). Despite adequate anesthesia, surgical incision increased MAP, which tended to be less in DM (ND +21 ± 4 vs. DM +13 ± 2 ΔmmHg, P = 0.052). Anesthesia disrupted central baroreflex HR responses to sympathetic activation (sodium nitroprusside 10 μg·kg−1, ND conscious 83 ± 13 vs. anesthetized 16 ± 5 Δbpm; P < 0.05) or to sympathetic withdrawal (phenylephrine 10 μg·kg−1, ND conscious −168 ± 37 vs. anesthetized −20 ± 6 Δbpm; P < 0.05) with no additional changes observed after surgical incision or during diabetes. During perioperative conditions, type 2 diabetes did not impact on short‐term hemodynamic regulation. Anesthesia had the largest hemodynamic impact, whereas surgical effects were limited to modulation of baseline blood pressure.

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Frequency components of systolic blood pressure variability reflect vasomotor and cardiac sympathetic functions in conscious rats

Cited by 24 publications

References 29 publications

Effects of aerobic conditioning on cardiovascular sympathetic response to and recovery from challenge

Effects of aerobic conditioning on cardiovascular sympathetic response to and recovery from challenge

Circadian Rhythm of Blood Pressure in Diabetes Mellitus: Evidence, Mechanisms and Implications

Effect of type 2 diabetes, surgical incision, and volatile anesthesia on hemodynamics in the rat

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