This paper studies the implementation strategy of an online tracking simulation system for the 660 MW ultra supercritical circulating fluidized bed boiler (USCFB). The establishment of the online system can be divided into offline and online phases. In the offline phase, the high-precision model and initial condition database of the boiler are first established. After the initial conditions are loaded, the initial conditions are adjusted through mass and energy compensation to make the initial state of the model consistent with the current operating state of the unit. In the online phase, this paper analyzes the global sensitivity of the 660 MW USCFB, establishes an online tracking mechanism based on the PI controller, and conducts simulation tests. The experiment shows that the tracking simulation system established in this paper can track the analog signal quickly and accurately.