Frequency-dependent transversal flow control in centrifugal microfluidics

Brenner, Thilo; Glatzel, Thomas; Zengerle, Roland; Ducrée, Jens

doi:10.1039/b406699e

Cited by 121 publications

(86 citation statements)

References 7 publications

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“…Kim et al 22 developed a flow switch by using a capillary valve upstream of an open chamber and unique threedimensional (3D) junction geometry. A similar router, solely 1 controlled by the rotationally actuated hydrodynamic Coriolis pseudo-force, was reported by Brenner et al 23 . This virtual routing concept was further refined by Haeberle et al, who successfully extracted DNA from calf thymus using silica beads by alternating the sense of rotation 24 .…”

Section: Introductionmentioning

confidence: 72%

Phase-selective graphene oxide membranes for advanced microfluidic flow control

et al. 2016

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For the first time, we harness the unique phase-selectivity of chip-integrated graphene oxide (GO) membranes to significantly enhance flow control on centrifugal microfluidic platforms. In this paper, we present novel processes for the assembly of these GO membranes into polymeric microfluidic systems and demonstrate that multilayer GO membranes allow the passage of water while blocking pressurized air and organic solutions.

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Section: Introductionmentioning

confidence: 72%

Phase-selective graphene oxide membranes for advanced microfluidic flow control

et al. 2016

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“…The relevant RPM burst frequency value for siphon priming is of interest here, and so the system modeled is taken to be in a steady-state mode. Dynamic forces, such as the Coriolis force, are not present in such equilibrium states, and so are not considered (Brenner et al 2005). The channels being modeled have a dimension in the Z-axis (out of the CD plane) of 100 lm, which is much smaller than the X-Y dimension of the channel, 1 mm.…”

Section: Analytical Analysismentioning

confidence: 99%

Serial siphon valving for centrifugal microfluidic platforms

Siegrist

Gorkin

Clime

et al. 2009

Microfluid Nanofluid

130

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Today, the focus in microfluidic platforms for diagnostics is on the integration of several analysis steps toward sample-to-answer systems. One of the main challenges to integration is the requirement for serial valving to allow the sequential release of fluids in a temporally and spatially controlled manner. The advantages offered by centrifugal microfluidic platforms make them excellent candidates for integration of biological analysis steps, yet they are limited by the lack of robust serial valving technologies. This is especially true for the majority of centrifugal microfluidic devices that rely on hydrophilic surfaces, where few passive serial valving techniques function reliably. Building on the useful functionality of centrifugal microfluidic siphoning previously shown, a novel serial siphon valve is introduced that relies on multiple, inline siphons to provide for a better controlled, sequential release of fluids. The introduction of this novel concept is followed by an analytical analysis of the device.Proof-of-concept is also demonstrated, and examples are provided to illustrate the range of functionality of the serial siphon valve. The serial siphon is shown to be robust and reproducible, with variability caused by the dependence on contact angle, rotation velocity, and fluidic properties (viz., surface tension) significantly reduced compared to current microfluidic, centrifugal serial valving technologies.

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“…The permeability of a channel on a microfluidic CD has been calculated and measured [34][35][36][37] to be…”

Section: A Microfluidic Cdsmentioning

confidence: 99%

Invited Review Article: Review of centrifugal microfluidic and bio-optical disks

Nolte

2009

Review of Scientific Instruments

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Spinning biodisks have advantages that make them attractive for specialized biochip applications. The two main classes of spinning biodisks are microfluidic disks and bio-optical compact disks ͑BioCD͒. Microfluidic biodisks take advantage of noninertial pumping for lab-on-a-chip devices using noninertial valves and switches under centrifugal and Coriolis forces to distribute fluids about the disks. BioCDs use spinning-disk interferometry, under the condition of common-path phase quadrature, to perform interferometric label-free detection of molecular recognition and binding. The optical detection of bound molecules on a disk is facilitated by rapid spinning that enables high-speed repetitive sampling to eliminate 1 / f noise through common-mode rejection of intensity fluctuations and extensive signal averaging. Multiple quadrature classes have been developed, such as microdiffraction, in-line, phase contrast, and holographic adaptive optics. Thin molecular films are detected through the surface dipole density with a surface height sensitivity for the detection of protein spots that is approximately 1 pm. This sensitivity easily resolves a submonolayer of solid-support immobilized antibodies and their antigen targets. Fluorescence and light scattering provide additional optical detection techniques on spinning disks. Immunoassays have been applied to haptoglobin using protein A/G immobilization of antibodies and to prostate specific antigen. Small protein spots enable scalability to many spots per disk for high-throughput and highly multiplexed immonoassays.

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Frequency-dependent transversal flow control in centrifugal microfluidics

Cited by 121 publications

References 7 publications

Phase-selective graphene oxide membranes for advanced microfluidic flow control

Phase-selective graphene oxide membranes for advanced microfluidic flow control

Serial siphon valving for centrifugal microfluidic platforms

Invited Review Article: Review of centrifugal microfluidic and bio-optical disks

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