Frequency-domain photothermoacoustics: Alternative imaging modality of biological tissues

Telenkov, Sergey A.; Mandelis, Andreas; Lashkari, Bahman; Forcht, Michael

doi:10.1063/1.3116136

Cited by 73 publications

(57 citation statements)

References 36 publications

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“…The acoustic signal level acquired in frequency-domain photoacoustics is reported several orders smaller than that in time-domain photoacoustics 27 under similar irradiation and depth conditions. It should be noticed that Eq.…”

Section: Discussionmentioning

confidence: 99%

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Magnetothermoacoustics from magnetic nanoparticles by short bursting or frequency chirped alternating magnetic field: A theoretical feasibility analysis

et al. 2013

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Purpose:To propose an alternative method of thermoacoustic wave generation based on heating of magnetic nanoparticles (MNPs) using alternating magnetic field (AMF). Methods: The feasibility of thermoacoustic wave generation from MNPs by applying a short-burst of AMF or a frequency-modulated AMF is theoretically analyzed. As the relaxation of MNPs is strongly dependent upon the amplitude and frequency of AMF, either an amplitude modulated, fixed frequency AMF (termed time-domain AMF) or a frequency modulated, constant amplitude AMF (termed frequency-domain AMF) will result in time-varying heat dissipation from MNPs, which has the potential to generate thermoacoustic waves. Following Rosensweig's model of specific power loss of MNPs in a steady-state AMF, the time-resolved heat dissipations of MNPs of superparamagnetic size when exposed to a short bursting of AMF and/or to a linearly frequency chirped AMF are derived, and the resulted acoustic propagation is presented. Based on experimentally measured temperaturerise characteristics of a superparamagnetic iron-oxide nanoparticle (SPION) matrix in a steady-state AMF of various frequencies, the heat dissipations of the SPION under time-domain and frequencydomain AMF configurations that could have practical utility for thermoacoustic wave generation are estimated. Results:The initial rates of the temperature-rise of the SPION matrix were measured at an ironweight concentration of 0.8 mg/ml and an AMF frequency of 88.8 kHz to 1.105 MHz. The measured initial rates of temperature-rise were modeled by Rosensweig's theory, and projected to 10 MHz AMF frequency, at which a 1 μs bursting corresponding to a 1.55 mm axial resolution of acoustic detection could contain 10 complete cycles of AMF oscillation and the power dissipation is approximately 84 times of that at 1 MHz. Exposing the SPION matrix to a 1 μs bursting of AMF at 10 MHz frequency and 100 Oe field intensity would produce a volumetric heat dissipation of 7.7 μJ/cm 3 over the microsecond duration of the AMF burst. If the SPION matrix is exposed to a 1 ms long AMF train at 100 Oe field intensity that chirps linearly from 1 to 10 MHz, the volumetric heat dissipation produced over each 2π phase change of the AMF oscillation is estimated to increase from 0.15 to 1.1 μJ/cm 3 within the millisecond duration of the chirping of AMF. Conclusions: The heat dissipations upon SPION (∼1 mg/ml iron-weight concentration) by a 1 μs bursting of 100 Oe AMF at 10 MHz and a 1 ms train of 100 Oe AMF that chirps linearly from 1 to 10 MHz were estimated to determine the potential of thermal-acoustic wave generation. Although thermoacoustic wave generation from MNPs by time-or frequency-domain AMF applications is predicted, the experimental generation of such a wave remains challenging. © 2013 American Association of Physicists in Medicine. [http://dx

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Section: Discussionmentioning

confidence: 99%

“…27 Equation (33) states that an AMF of fixed frequency (at constant intensity as is CW AMF), as it gives rise to a constant q upon the mediation of MNPs, does not induce thermoacoustic wave.…”

Section: Iic Frequency-domain Magneto Thermoacoustics From Mnps Expmentioning

confidence: 99%

Magnetothermoacoustics from magnetic nanoparticles by short bursting or frequency chirped alternating magnetic field: A theoretical feasibility analysis

et al. 2013

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“…In cases where the peak optical power is limited rather than the total optical energy, the optimal tradeoff between SNR and spatial resolution can be achieved by using pulse compression. In this technique, which is well known in radar theory and also in ultrasonography and a few recent works in photoacoustics [6][7][8], the transmitted pulse has linear frequency modulation (LFM) of the form:…”

Section: Theorymentioning

confidence: 99%

A highly flexible pulsed photoacoustic setup based on a tunable laser source and external modulation

Sheinfeld¹,

Gilead²,

Eyal³

2010

J. Phys.: Conf. Ser.

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Abstract. In this paper performance enhancement in PA measurements through optical pulse shaping is explored and demonstrated. A recently introduced setup, which is based on a CW tunable laser source operating in the optical communications band (1510-1620nm) and an electro-optic modulator, offers exceptional flexibility in controlling the temporal and spectral characteristics of the excitation waveform. Despite its being remarkably simple to construct and to operate, the unique optical configuration of this setup opens the possibility for a range of attractive applications which cannot be implemented by the commonly used pulsed lasers: responsivity and sensitivity optimization through pulse-shaping, enhancement of spatial resolution through pulse compression and simple implementation of high-resolution quantitative spectroscopy. IntroductionPhotoacoustic (PA) imaging is a field of growing interest, especially for biomedical applications, where it combines the advantages of the high contrast achieved by optical absorption and the high spatial resolution obtained via ultrasound detection [1]. Photoacoustic spectroscopy (PAS) for biomedical uses has also attracted much attention mainly due to its compatibility to in-vivo applications. The optical sources in most PA setups are either Q-switched or mode-locked pulsed lasers with pulse-widths in the nanoseconds range. While providing robust and high-power excitation, such sources allow very limited control over the pulse temporal shape, and in many cases also have limited spectral tunability. One method to control the temporal characteristics of the optical excitation is via direct modulation of laser diodes, however achieving short rise times using this approach is often difficult due to dynamical effects such as ringing and pulse distortion [2].Recently we have introduced a PA setup that allows simple and accurate control of the excitation pulse via external modulation of a CW optical source [3,4]. The current implementation of the setup comprises a CW tunable laser operating in the optical communication band and an electro-optic external modulator (EOM) driven by an arbitrary waveform generator (AWG). This modulation method allows synthesis of ultra broadband waveforms with arbitrary shapes. The current spectral range of the setup, around 1550nm, has indeed a disadvantage of relatively high absorption and short penetration depth in water, which might limit its usage for biomedical imaging applications. However, this setup was constructed as a test platform for exploring and demonstrating the benefits of pulseshaping in PA applications. Similar waveform synthesis implementations at other interesting wavelength ranges are currently under development.

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“…Low cost and compact PA imaging techniques that do not rely on nanosecond pulsed laser systems are useful for educational and research laboratories with limited resources and for global healthcare. [7][8][9][10][11] In this study, we have developed a frequency-domain PA (FD-PA) imaging system by using an inexpensive laser diode, a conventional single element ultrasound transducer, and a lock-in amplifier to improve the signal-to-noise ratio. [12][13][14][15][16] The theory and the experimental implementation of FD-PA have been extensively described in the literature.…”

Section: Introductionmentioning

confidence: 99%

Feasibility of Prostate Cancer Diagnosis by Transrectal Photo-acoustic Imaging

Liu¹

2013

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Frequency-domain photothermoacoustics: Alternative imaging modality of biological tissues

Cited by 73 publications

References 36 publications

Magnetothermoacoustics from magnetic nanoparticles by short bursting or frequency chirped alternating magnetic field: A theoretical feasibility analysis

Magnetothermoacoustics from magnetic nanoparticles by short bursting or frequency chirped alternating magnetic field: A theoretical feasibility analysis

A highly flexible pulsed photoacoustic setup based on a tunable laser source and external modulation

Feasibility of Prostate Cancer Diagnosis by Transrectal Photo-acoustic Imaging

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