In this paper, a 450 km simulation circle method is used to extract all meteorological records from 1949 to 2018, and to obtain random samples. The Yanmeng typhoon wind field model is compiled by MATLAB, the optimal typhoon wind profile index α is calculated. The harmonic superposition method is used to simulate the typhoon wind field at the construction site. Stress time-history of cables under buffeting is analyzed using ANSYS and MATLAB. Palmgren-miner linear cumulative fatigue damage method is used for fatigue damage analysis, combined with rain flow counting method and S-N curve. It is shown that the damage value of cable increases with the growth of wind speed. The damage of cable has a similar trend with the variance of axial stress. The cable of middle span, about an eighth of the way to bridge tower, is extremely sensitive to the wind. The low stress region is the main circulating region of the cable. The region of low stress expands with the increase of wind speed. The amplitude of cable stress mainly circulates from low amplitude to high amplitude with the increase of wind speed.