Frequency, intensity and localization of pain as risk factors for frailty in older adults

Rodríguez-Sánchez, Isabel; García‐Esquinas, Esther; Mesas, Arthur Eumann; Martín-Moreno, José M.; Rodríguez‐Mañas, Leocadio; Rodríguez‐Artalejo, Fernando

doi:10.1093/ageing/afy163

Cited by 38 publications

(25 citation statements)

References 24 publications

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“…Furthermore, widespread rather than localized pain was associated with increasing frailty, and somatic rather than visceral and neuropathic pain was associated with a higher degree of frailty. On the other hand, the frailty index was not influenced by the intensity of pain, ranked as mild, moderate or severe [ 32 , 33 ]. Surprised by this finding, we chose to evaluate pain intensity separately for chronic pain, but even this analysis failed to show a relationship with the frailty index.…”

Section: Discussionmentioning

confidence: 99%

Pain and Frailty in Hospitalized Older Adults

et al. 2020

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Introduction Pain and frailty are prevalent conditions in the older population. Many chronic diseases are likely involved in their origin, and both have a negative impact on quality of life. However, few studies have analysed their association. Methods In light of this knowledge gap, 3577 acutely hospitalized patients 65 years or older enrolled in the REPOSI register, an Italian network of internal medicine and geriatric hospital wards, were assessed to calculate the frailty index (FI). The impact of pain and some of its characteristics on the degree of frailty was evaluated using an ordinal logistic regression model after adjusting for age and gender. Results The prevalence of pain was 24.7%, and among patients with pain, 42.9% was regarded as chronic pain. Chronic pain was associated with severe frailty (OR = 1.69, 95% CI 1.38–2.07). Somatic pain (OR = 1.59, 95% CI 1.23–2.07) and widespread pain (OR = 1.60, 95% CI 0.93–2.78) were associated with frailty. Osteoarthritis was the most common cause of chronic pain, diagnosed in 157 patients (33.5%). Polymyalgia, rheumatoid arthritis and other musculoskeletal diseases causing chronic pain were associated with a lower degree of frailty than osteoarthritis (OR = 0.49, 95%CI 0.28–0.85). Conclusions Chronic and somatic pain negatively affect the degree of frailty. The duration and type of pain, as well as the underlying diseases associated with chronic pain, should be evaluated to improve the hospital management of frail older people. Electronic Supplementary Material The online version of this article (10.1007/s40122-020-00202-3) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Pain and Frailty in Hospitalized Older Adults

et al. 2020

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“…Chronic pain substantially affects older adults' mood, daily activities, mobility, and physical inactivity and has been associated with an increased risk of frailty [1,3,[6][7][8][9][10][11] and disability. The estimated annual cost of chronic pain in the United States, including direct medical costs and lost productivity, is between $560 and $635 billion, further emphasizing the need for therapeutic intervention approaches [1].…”

Section: Introductionmentioning

confidence: 99%

Feasibility of a yoga intervention to decrease pain in older women: a randomized controlled pilot study

Seguin‐Fowler¹,

Graham

Ward

et al. 2020

BMC Geriatr

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Background A significant proportion of older women suffer from chronic pain, which can decrease quality of life. The objective of this pilot randomized study was to evaluate the feasibility of a flow-restorative yoga intervention designed to decrease pain and related outcomes among women aged 60 or older. Methods Flow-restorative yoga classes were held twice weekly for 1 hour and led by a certified yoga instructor. Participants randomized to the intervention group attended the yoga classes for 12 weeks and received supplemental materials for at-home practice. Those randomized to the control group were asked to maintain their normal daily routine. Feasibility was evaluated using recruitment and retention rates, class and home practice adherence rates, and participant satisfaction surveys. Outcome measures (self-reported pain, inflammatory markers, functional fitness, quality of life, resilience, and self-reported physical activity) were assessed at baseline and post-intervention. Paired t-tests or Wilcoxon signed-rank tests were used to examine changes in outcome measures within treatment groups. Results Thirty-eight participants were recruited and randomized. Participants were primarily white, college-educated, and higher functioning, despite experiencing various forms of chronic pain. Attendance and retention rates were high (91 and 97%, respectively) and the majority of participants were satisfied with the yoga program (89%) and would recommend it to others (87%). Intervention participants also experienced reductions in pain interference and improvements in energy and social functioning. Conclusions This pilot study provides essential data to inform a full scale randomized trial of flow-restorative yoga for older women with chronic pain. Future studies should emphasize strategies to recruit a more diverse study population, particularly older women at higher risk of disability and functional decline. Trial registration Clinicaltrials.gov, NCT03790098. Registered 31 December 2018 – Retrospectively registered

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“…Polypharmacy was 3.12 times more likely to increase the risk of frailty than no polypharmacy. The relationship among frailty, comorbidity and polypharmacy may go both ways [ 38 ]. The reason is that frailty is associated with certain chronic diseases and multimorbidity, which can lead to polypharmacy.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the correlation between frailty and sleep quality among elderly patients with osteoporosis: a cross-sectional study

Zhou

Liu

et al. 2022

BMC Geriatr

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Background The incidence of osteoporosis increases with age. Frailty is a distinct characteristic seen in older osteoporosis patients. Poor sleep quality is common in elderly individuals. However, there are few studies on the correlation between frailty and sleep quality in elderly patients with osteoporosis in China. Methods This cross-sectional study was conducted from December 8, 2020, to April 30, 2021. A total of 247 patients who met the inclusion and exclusion criteria were recruited in outpatient departments at West China Hospital. A self-designed demographic data questionnaire, the Pittsburgh Sleep Quality Index (PSQI), and the Frailty Phenotype scale were used to evaluate the sleep quality and frailty of the participants. Multivariate logistic regression was performed to evaluate the factors affecting frailty and sleep quality in osteoporosis patients. Results A total of 231 valid questionnaires were statistically analysed. The mean frailty score was 3.2 ± 1.6 and a total of 152 (65.8%) were frailty. The mean PSQI score was 11.9 ± 4.5 and a total of 183 (79.2%) patients had poor sleep quality (PSQI > 7). Multiple logistic regression showed that female, pain, polypharmacy, activities of daily living status (ADLs), and sleep quality were independent influencing factors for frailty, while comorbidity, ADLs and frailty status were independent influencing factors for sleep quality. Conclusion We found that frailty and sleep quality were prevalent and that frailty was positively correlated with the PSQI score in elderly patients with osteoporosis in China. The higher the frailty score is, the worse the sleep quality. It means the frailer old patients were, the worse their sleep quality, and poor sleep quality may increase the risk of frailty in elderly patients with osteoporosis. To manage elderly patients with osteoporosis effectively, medical staff should pay attention to frailty, sleep quality and its influencing factors.

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Frequency, intensity and localization of pain as risk factors for frailty in older adults

Cited by 38 publications

References 24 publications

Pain and Frailty in Hospitalized Older Adults

Pain and Frailty in Hospitalized Older Adults

Feasibility of a yoga intervention to decrease pain in older women: a randomized controlled pilot study

Evaluation of the correlation between frailty and sleep quality among elderly patients with osteoporosis: a cross-sectional study

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