Frequency, Levels and Predictors of Potential Drug-Drug Interactions in a Pediatrics Ward of a Teaching Hospital in Pakistan

Ismail, Muhammad; Iqbal, Zafar; Khan, M. Ishaque; Javaid, Arshad; Arsalan, Hassan; Farhadullah, H; Khan, Fahadullah; Az, Khan; Nasir, F; Ja, Khan

doi:10.4314/tjpr.v12i3.19

Cited by 20 publications

(51 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In our study, the prevalence of pDDIs was larger than reported by Ismail et al who found a 25.8% prevalence. 14 It is striking that this last author reports a prevalence of 25.8% in a study similar to ours, when most published studies report between 40 and 50%. This difference could be due to the fact that the study was done at a teaching hospital and doctors may be more vigilant in the prescription stage or the doctor in charge of the area may even provide a post-prescription review.…”

Section: Discussionsupporting

confidence: 85%

Pilot study: Evaluation of potential drug–drug interactions in hospitalized pediatric patients

Medina-Barajas

Vázquez-Méndez

Pérez-Guerrero

et al. 2020

Pediatrics & Neonatology

View full text Add to dashboard Cite

drug-drug interactions; medication errors; pediatric patients; potential drug-drug interactions Purpose: Evaluate the type and severity of potential drug-drug interactions and identify risk factors involved, in pediatric patients admitted in a hospital setting. Methods: Transversal retrospective analytical study was carried out with hospitalized pediatric patients from a Hospital in the West of Mexico, second and third level. The patients included were 18 years old hospitalized in the children wards; those admitted at the emergency room, neonatal intermediate and intensive therapy units were not included. Medical prescriptions were reviewed taking into consideration anthropometric characteristics, diagnosis and number of drugs prescribed to identify potential drugedrug interactions using Micromedex 2.0 database.

show abstract

Section: Discussionsupporting

confidence: 85%

Pilot study: Evaluation of potential drug–drug interactions in hospitalized pediatric patients

Medina-Barajas

Vázquez-Méndez

Pérez-Guerrero

et al. 2020

Pediatrics & Neonatology

View full text Add to dashboard Cite

show abstract

“…This is similar to results obtained in a study conducted by Ismail et al [34] which showed 45 % potential drug-drug interactions at pulmonology ward in a tertiary care hospital at Peshawar, Pakistan. Our results confirm that drug-drug interaction is a common drug therapy problem in both government and private hospitals.…”

Section: Discussionsupporting

confidence: 82%

Evaluation of drug therapy problems among renal patients receiving care in some tertiary hospitals in Nigeria

Adibe¹,

Igboeli²,

Ukwe³

2017

Trop. J. Pharm Res

View full text Add to dashboard Cite

show abstract

“…The severity of the majority of the possible DDIs in this study was observed to be moderate. This result was found to be similar with the study done by Mohammad Ismail et al [16] and Qorraj-Bytyqi et al [25]. The drug combinations amikacin+ampicillin, paracetamol +phenytoin and ofloxacin+ondansetron were found to be the frequently observed possible DDIs of minor, moderate and major severities respectively.…”

Section: Discusssionsupporting

confidence: 91%

“…Majority of the studies investigated the possible DDIs in different specialties like general medicine, oncology, cardiology, pulmonology and psychiatry where the information is just restricted to the adult population [16][17][18][19][20][21][22][23]. Very few studies were performed in the pediatrics specialty and hence, in this study we made an attempt to study the prevalence and severity of possible drug-drug interactions in pediatrics specialty.…”

Section: Introductionmentioning

confidence: 99%

A Study on the Prevalence and Severity of Possible Drug-Drug Interactions in Pediatrics Department at an Indian Tertiary Care Teaching Hospital

Sripada

Kumar

Devanna

et al. 2018

Int J Pharm Pharm Sci

View full text Add to dashboard Cite

Objective: To study the prevalence and severity of possible drug-drug interactions in the department of pediatrics. Methods:Case records of the in-patients of the pediatrics department from the medical records department were included and the records of the ambulatory patients were excluded from the study. All the collected cases were subjected to check for the drug-drug interactions by using the software micromedex 2.0 and the interactions were categorized based on the severity into minor, moderate and major.Results: A total of 142 cases were screened for possible drug-drug interactions (DDIs) and among them 76 cases were observed to be with possible DDIs. The prevalence was found to be 53.5% in this study. Majority of the cases with possible DDIs were observed to be in females. Results of the age wise categorization revealed that majority of the possible DDIS were observed in children (2-12 y) followed by the infants (1 mo-2 y). The drug combinations amikacin+ampicillin, paracetamol+phenytoin and ofloxacin+ondansetron were found to be the frequently observed possible DDIs of minor, moderate and major severities respectively. Conclusion:Majority of the possible DDIs were of moderate severity followed by major. Clinical pharmacists should take the responsibility in assisting the pediatricians for screening the possible DDIs in the prescriptions there by preventing them and providing a better pharmaceutical care for the pediatric population.

show abstract

Frequency, Levels and Predictors of Potential Drug-Drug Interactions in a Pediatrics Ward of a Teaching Hospital in Pakistan

Abstract: Purpose: To identify the frequency, levels and predictors of potential drug-drug interactions (pDDIs) in a pediatrics ward of a teaching hospital in

Cited by 20 publications

References 17 publications

Pilot study: Evaluation of potential drug–drug interactions in hospitalized pediatric patients

Pilot study: Evaluation of potential drug–drug interactions in hospitalized pediatric patients

Evaluation of drug therapy problems among renal patients receiving care in some tertiary hospitals in Nigeria

A Study on the Prevalence and Severity of Possible Drug-Drug Interactions in Pediatrics Department at an Indian Tertiary Care Teaching Hospital

Contact Info

Product

Resources

About