Frequency of Abdominal Aortic Aneurysm in Patients &gt;60 Years of Age With Coronary Artery Disease

Maďarič, Juraj; Vulev, Ivan; Bartúnek, Jozef; Mistrik, A.; Verhamme, Katia; Bruyne, Bernard De; Riečanský, I

doi:10.1016/j.amjcard.2005.06.058

Cited by 57 publications

(46 citation statements)

References 18 publications

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“…Five out of these 7 studies reported no association, while one showed an association by univariate analysis which was no more significant by multivariate analysis (Madaric et al 2005). Shirani et al reported a significantly higher frequency of AAA in diabetic patients compared with non diabetic ones (3.2% versus 1.4%, p=0.033) (Shirani et al, 2009).…”

Section: Diabetes Mellitusmentioning

confidence: 99%

“…AAA diameter in these studies ranged between 25 and 87 mm. Five studies included a control population, age and sex matched in most cases, and without angiographic CAD (Bergersen et al, 1998;Bonamigo & Siqueira, 2003;Madaric et al, 2005;Nemati et al, 2009;Wang et al, 2008). AAA prevalence in these control groups were always significantly below the prevalence in the CAD group, ranging from 0 to 3.3%.…”

Section: Characteristics Of Abdominal Aortic Aneurysm In Coronary Artmentioning

confidence: 99%

See 1 more Smart Citation

Abdominal Aortic Aneurysm in Patients with Coronary Artery Disease: A Review Article

Elkalioubie¹,

Jude²,

Dupont³

2011

Diagnosis and Treatment of Abdominal and Thoracic Aortic Aneurysms Including the Ascending Aorta and the Aortic Arch

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Section: Diabetes Mellitusmentioning

confidence: 99%

Section: Characteristics Of Abdominal Aortic Aneurysm In Coronary Artmentioning

confidence: 99%

Abdominal Aortic Aneurysm in Patients with Coronary Artery Disease: A Review Article

Elkalioubie¹,

Jude²,

Dupont³

2011

Diagnosis and Treatment of Abdominal and Thoracic Aortic Aneurysms Including the Ascending Aorta and the Aortic Arch

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“…33 Moreover, there is evidence that the relationship between smoking and AAA is stronger among older patients (>60 years) with coronary artery disease. 34 Another study in men over the age of 50 years showed that current smokers were 7.6-fold more susceptible to AAA than nonsmokers (95% CI 3.3-17.8). 35 Moreover, exsmokers were 3-fold more likely to have an AAA (95% CI 1.4-6.4).…”

Section: Clinical Evidencementioning

confidence: 99%

“…61 It is important to note that both MMP activity and MMP-1, -2 and -9 content are decreased in the vascular tissue of diabetic patients. 34 Moreover, diabetes is associated with modification and glycation of collagen and with resistance to MMP digestion. 62 These findings may in part explain the inverse association between the incidence of diabetes and AAA observed in studies.…”

Section: Pathophysiologymentioning

confidence: 99%

Smoking and Aortic Diseases

Kakafika

Mikhailidis

2007

Circ J

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Cigarette smoking is a major cause of cardiovascular disease (CVD) and is responsible for approximately 11% of the annual total CVD deaths in the United States. 1 Smoking acts synergistically with other vascular risk factors (eg, hypertension, dyslipidaemia and diabetes) to increase vascular morbidity and mortality. 2 However, smoking has a variable magnitude of increased risk for different vascular diseases: the risk is highest for peripheral arterial disease and aortic aneurysm, and is lowest for coronary artery and cerebrovascular diseases. 2 These effects are thought to reverse after smoking cessation. The constituents of cigarette smoke with the major contribution to pathogenesis of vascular disease are nicotine, carbon monoxide, oxidant gases and polycyclic aromatic hydrocarbons. 2 Nonsmokers who are exposed to "secondhand" smoke experience on average a 30% excess risk of ischemic heart disease and nonfatal myocardial infarction. 3 Secondhand smoke exposure has been shown to activate platelets and to produce endothelial dysfunction, in both experimental animals and humans. 3 The mechanisms by which smoking causes acute cardiovascular events include endothelial dysfunction, thrombosis and inflammation.Endothelial dysfunction is an initiating event in atherogenesis, as well as a major factor in causing acute cardiovascular events. Cigarette smoking impairs flow-mediated endothelium-dependent peripheral arterial vasodilatation, an effect that is, at least partly, reversible after smoking Circulation Journal Vol.71, August 2007 cessation. 4 Smokers without atherosclerosis have coronary vasoconstrictor responses to acetylcholine that, in the presence of normal endothelium, produce vasodilatation. 5 Indeed, the oxidant chemicals of smoke degrade nitric oxide (NO) and reduce NO release, with subsequent impairment of vascular dilation and platelet function. 2 Smokers have lower than normal levels of antioxidant vitamins, reflecting their consumption in response to ongoing oxidant stress. 6 In addition, nicotine itself alters the structural and functional characteristics of vascular smooth muscle cells (VSMC) and endothelial cells. 7,8 Experimental data show that human aortic endothelial cells undergo apoptotic changes when they are exposed to cigarette smoke extracts. 9 This process may be prevented by pre-activation of NO synthase by Larginine. 9,10 Furthermore, smoking causes an increase in vascular superoxide production, which results in decreased NO bioactivity and concomitantly increases production of vasoconstrictor eicosanoids. 11 Cigarette smoke extracts, but not nicotine, also inhibit prostacyclin (PGI2: a vasodilator and inhibitor of platelet aggregation) synthesis in human, rabbit and rat vascular tissue. 12 Smoking-mediated endothelial dysfunction also results in reduced secretion of tissue plasminogen activator (tPA) 13 and increased secretion of plasminogen activator inhibitor (PAI)-1, 1 which results in impaired fibrinolysis. This acts in concert with the increased levels of tissue factor and fibrin...

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“…However, the prevalence of AAA in patients with known CAD has been reported to be about 5-8%. [22] The underlying factors in the pathogenesis of AAA and atherosclerosis were identified as being similar in a 20-year follow-up study of 8000 males. [2] Therefore, investigating the risk factors of CAD in AAA patients could be beneficial for the early diagnosis and prevention of further surgical complications.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of coronary artery disease and other risk factors in patients with abdominal aortic aneurysm

Fedakar¹

2011

Turkish J Thorac Cardiovasc Surg

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Amaç: Bu çalışmada abdominal aort anevrizması (AAA) ile koroner arter hastalığı (KAH) ve diğer risk faktörleri arasındaki ilişki araştırıldı. Ça lış ma pla nı: Ocak 1998 -Aralık 2008 tarihleri arasında kliniğimizde ameliyat edilen cerrahi sınırlardaki AAA'lı 163 hasta (145 erkek, 18 kadın; ort. yaş 64.4±8.9 yıl; dağılım 39-88 yıl) çalışmaya dahil edildi ve hastane tarafından sağlanan hasta kayıtları geriye dönük olarak incelendi. Bul gu lar: En sık eşlik eden risk faktörleri hipertansiyon (%79.8), sigara kullanımı (%70.6), KAH (%50.3), kronik obstrüktif akciğer hastalığı (KOAH) (%36.8), yüksek serum üre seviyesi (%9.2) ve periferal arter hastalığı (%2.5) idi. Hastalar KAH varlığına göre gruplandırıl-dı ve risk faktörleri açısından karşılaştırıldı. Gruplar yaş, semptomlar, anevrizma çapı ve boyu, hipertansiyon, KOAH, serum üre seviyesi, yoğun bakım ünitesinde kalış süresi, taburcu olana kadar geçen süre ve komplikasyonlar yönünden karşılaştırıldığında gruplar arasında anlamlı bir fark saptanmadı. Bununla beraber, KAH grubunda sigara içenlerin sayısı KAH'siz gruba göre anlamlı düzeyde daha yüksekti. Koroner arter bypass greftleme işlemi genellikle KAH grubundaki anevrizma çapı daha yüksek olan hastalarda yapıldı. So nuç:Aort anevrizması ile KAH ve diğer risk faktörleri arasındaki ilişki araştırıldığında, AAA'lı hastalar arasın-daki sigara kullanımı, KAH'li hastalarda anlamlı olarak daha yüksek bulundu. Koroner arter bypass greftleme işle-minin anevrizma çapı daha yüksek olan hasta grubunda daha gerekli olduğu tespit edildi.Anah tar söz cük ler: Abdominal aort anevrizması; aort cerrahisi; koroner arter hastalığı/epidemiyoloji/risk faktörleri; hipertansiyon.

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Frequency of Abdominal Aortic Aneurysm in Patients >60 Years of Age With Coronary Artery Disease

Cited by 57 publications

References 18 publications

Abdominal Aortic Aneurysm in Patients with Coronary Artery Disease: A Review Article

Abdominal Aortic Aneurysm in Patients with Coronary Artery Disease: A Review Article

Smoking and Aortic Diseases

Evaluation of coronary artery disease and other risk factors in patients with abdominal aortic aneurysm

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