2023
DOI: 10.1136/ijgc-2022-004142
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Frequency of actionable germline pathogenic variants identified through tumor next-generation sequencing in a gynecologic cancer cohort

Abstract: BackgroundTumor next-generation sequencing can identify potential germline pathogenic variants associated with cancer susceptibility.ObjectiveTo describe the frequency of tumor sequencing results that met European Society of Medical Oncology (ESMO) recommendations for further germline genetic testing, and the frequency of germline variants among a cohort with gynecologic cancer.MethodsPatients with gynecologic cancer who underwent tumor sequencing between September 2019 and February 2022 in a large healthcare … Show more

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