2022
DOI: 10.1001/jamanetworkopen.2022.46327
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Frequency of Acute Kidney Injury and Association With Mortality Among Extremely Preterm Infants

Abstract: ImportanceNeonatal acute kidney injury (AKI) is common and associated with morbidity and mortality. The temporal relationship between AKI and critical illness, as well as the frequency of AKI definition components (urine output and serum creatinine [sCr] concentration change), are unknown in extremely low-birth-weight (ELBW) (<1000 g), extremely preterm (<29 weeks’ completed gestational age [GA]) infants.ObjectiveTo measure the frequency of AKI from birth to death or discharge with attent… Show more

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Cited by 12 publications
(14 citation statements)
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“…8 Further work to understand how different neonatal AKI endotypes (hypoperfusion, nephrotoxicity, sepsis, and ischemia) impact outcomes is greatly needed as outlined in recent consensus guidelines on pediatric AKI in JAMA Network Open in October 2022. 8 A third possible reason for the findings of Aziz et al 1 suggesting that AKI has a negligible influence on death is the possibility of biases and collinearity in the statistical approach. Machine learning processes are not a panacea and are still subject to bias through incorrectly classified variables and models or incorrectly collected data points.…”
Section: + Related Articlementioning
confidence: 99%
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“…8 Further work to understand how different neonatal AKI endotypes (hypoperfusion, nephrotoxicity, sepsis, and ischemia) impact outcomes is greatly needed as outlined in recent consensus guidelines on pediatric AKI in JAMA Network Open in October 2022. 8 A third possible reason for the findings of Aziz et al 1 suggesting that AKI has a negligible influence on death is the possibility of biases and collinearity in the statistical approach. Machine learning processes are not a panacea and are still subject to bias through incorrectly classified variables and models or incorrectly collected data points.…”
Section: + Related Articlementioning
confidence: 99%
“…In their study on acute kidney injury (AKI) in extremely preterm infants, Aziz et al 1 provide supportive information about the prevalence of AKI and its association with mortality in extremely low-birthweight (ELBW) neonates. Using a contemporary neonatal AKI definition, this retrospective, observational, single-center cohort study of 436 ELBW infants shows a prevalence of early AKI of 44%, and those with any AKI had a 2.77 (95% CI, 1.63-4.72) higher odds of death compared with those without AKI (odds ratio for severe AKI, 3.52; 95% CI, 2.15-5.76).…”
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confidence: 99%
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