Frequency of Adverse Effects of Fixed Dose Combinations, in Tuberculosis and there Effects on Treatment Outcome

Abstract

Introduction: This study was designed to assess the frequency, types and impact of adverse drug reactions (ADR) to category 1 anti-tubercular therapy using fixed drug combinations (FDC). Patients with tuberculosis started on anti TB treatment from 01st of July 2011 to 30th of June 2012 were recruitedMethodology: Patients were followed up for development of ADR. Frequency of ADR, number of patients who required prolongation of therapy, who had alternate regimes, and there treatment outcome were recorded.Results: Out of 280 patients with tuberculosis 67 (24%), 37 (55.2%) males, 30 (44.8%) females ADR. Thirty three out of 74 (44%) of total population above the age of 60 had ADR, while only 34 out of 206 (16.5%) of patients below the age of 60 had ADR (Chi= 23, p <0.0001). Incidence of ADR were - Dyspeptic symptoms 31(11.1%), itching 20 (7.1%), hepatitis 9 (3.2%), arthralgia 1 (0.4%), vertigo 1 (0.4%), peripheral neuropathy 1 (0.4%), visual impairment 1 (0.4%), rash 1 (0.4%). Out of 27 patients who had prolongation of therapy 22 (81.4%) were due to ADR (Chi = 54, p <0.0001). Nine (3.2%) were given alternate regimes (Fishers exact p = 0.000017) [6 hepatitis, 1 rash, 1 vertigo, 1 visual impairment]. None of the patients with ADR had relapses or treatment failures.Conclusion: Adverse reactions were commoner among the elderly, and were associated with prolongation and modification of anti tuberculosis therapy but over all treatment outcomes were not adversely affected.SAARC J TUBER LUNG DIS HIV/AIDS, 2015 XII (2),Page: 8-12

Adverse drug reactions associated with first line anti-tubercular drugs, their prevalence and causality assessment in patients on Directly Observed Treatment Short-course (DOTS) in a tertiary care hospital

“…15 Similarly Athira et al, found that the majority of the ADRs were related to was gastro-intestinal tract, followed by skin reactions. 23 Similar results have been reported by Sood et al, Hassan et al, and Sribaddana et al 18,26,27 However study done by Aamir et al, had reported joint pain as the most common ADR while as a study done by Kurniawati et al, found skin reactions as the most common ADRs. 17,19 Another study done by Kheirollah et al, found that the most common ADR was hepatitis.…”