Frequency of ASCA Seropositivity in Children with Cystic Fibrosis

Condino, Adria A.; Hoffenberg, Edward J.; Accurso, Frank J.; Penvari, Chureeporn; Anthony, Meg; Gralla, Jane; OʼConnor, Judith

doi:10.1097/01.mpg.0000166801.61708.60

Cited by 27 publications

(20 citation statements)

References 18 publications

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“…The frequency of ASCA seropositivity in CF patients has only been analysed in one paediatric study [8]. In this study, ASCA were identified in 21% of patients, with ASCA-IgA being identified in 10%.…”

Section: Discussionmentioning

confidence: 88%

See 1 more Smart Citation

Prevalence and clinical significance of auto-antibodies in adults with cystic fibrosis

Lachenal

Nkana²,

Nové-Josserand³

et al. 2009

Eur Respir J

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The aim of this study was to determine the prevalence of different auto-antibodies in adult, French cystic fibrosis (CF) patients and to look for a correlation between autoimmunity, patient characteristics and survival.The sera of 144 patients were screened for a wide range of antibodies. Clinical, biological and bacteriological characteristics and the cystic fibrosis transmembrane conductance regulator genotype were recorded and progression of lung disease was examined.113 (78.5%) patients displayed one or several auto-antibodies, predominantly immunoglobulin (Ig)A anti-Saccharomyces cerevisiae antibodies (ASCA; 43.7%) and antineutrophil cytoplasmic antibodies (ANCA; 40%), of which 59% showed bactericidal/permeability-increasing protein (BPI) specificity. The presence of BPI-ANCA was associated with the number of antibiotic courses, low body mass index, Pseudomonas aeruginosa colonisation, the presence of resistant P. aeruginosa, low forced expiratory volume in 1 s, CF-related liver disease, hypergammaglobulinaemia, male sex and inflammatory syndrome. The presence of ASCA-IgA was correlated with male sex and hypergammaglobulinaemia. 41 patients presented with chronic respiratory failure and/or requested lung transplantation or died during follow-up. These events were more frequent in patients with BPI-ANCA or ASCA-IgA.These findings confirm the high frequency of auto-antibodies in CF, particularly BPI-ANCA and ASCA-IgA, and the link between BPI-ANCA, severity of lung disease and CF prognosis.

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Section: Discussionmentioning

confidence: 88%

“…Other antibodies, such as anti-Saccharomyces cerevisiae antibodies (ASCA), rheumatoid factor (RF) and antinuclear antibodies (ANA), known as antibodies with specific clinical expression, have selectively been described [8][9][10][11]. The clinical significance of the presence of such antibodies in CF and their link with disease severity is not yet established.…”

mentioning

confidence: 99%

Prevalence and clinical significance of auto-antibodies in adults with cystic fibrosis

Lachenal

Nkana²,

Nové-Josserand³

et al. 2009

Eur Respir J

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“…There have been reports of an increased prevalence of Crohn's disease, up to 12.5-fold greater in patients with CF than in the general population (Lloyd-Still 1994). Incident cases must be confirmed by biopsy, because serum markers for inflammatory bowel disease may be falsely positive or negative in patients with CF (Condino et al 2005).…”

Section: Inflammationmentioning

confidence: 99%

The Cystic Fibrosis Intestine

Lisle

Borowitz

2013

Cold Spring Harbor Perspectives in Medicine

175

203

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“…ASCA has also been detected in patients with other gastrointestinal diseases where there is an increase in intestinal permeability such as celiac disease and cystic fibrosis [27,35,36]. Significantly higher ASCA IgA levels were also reported in patients with spondyloarthopathies and, more specifically, in ankylosing spondylitis in comparison to healthy controls and patients with rheumatoid arthritis [37].…”

Section: Discussionmentioning

confidence: 93%

Anti-Saccharomyces cerevisiae Antibody Does Not Differentiate Between Crohn's Disease and Intestinal Tuberculosis

et al. 2006

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The clinical, morphological, and histological features of intestinal tuberculosis (IT) and Crohn's disease (CD) mimic so much, that it becomes difficult to differentiate between them. The sensitivity of anti-Saccharomyces cerevisiae antibody (ASCA) IgG and ASCA IgA in CD is 60%-80%, whereas the specificity is almost 90%. There are no reports of study of ASCA in patients with IT, nor has it ever been used to differentiate CD from IT. Patients with ulcerative colitis (UC; n=25), CD (n=59), and IT (n=30) and 21 healthy controls were included in this study. The location and behavior of CD were classified according to the Modified Montreal classification. Five milliliters of blood was taken from them and serum was stored at -70 degrees C. ASCA antibodies (both IgG and IgA) were estimated using commercially available ELISA kits (AESKU Diagnostics, Germany). Anti-neutrophilic cytoplasmic antibody was measured by indirect immunofluorescence test. ASCA IgA was positive in 4.7%, 28%, 33.9%, and 43.3% and ASCA IgG was positive in 4.7%, 24%, 50.8%, and 46.6% of healthy controls and patients with UC, CD, and IT, respectively. Either ASCA IgG or ASCA IgA was positive in 9.5%, 40%, 61% and 66.6% of healthy controls, UC, CD, and IT, respectively. ANCA was positive in 0%, 32%, 10.1%, and 6.6% of healthy controls, UC, CD, and IT, respectively. ASCA IgG was positive in a significantly higher number of patients with CD (P<0.0001) and IT (P<0.0001) in comparison to healthy controls. ASCA IgA was positive in a significantly higher number of patients with UC (P<0.04), CD (P<0.013), and IT (P<0.006) in comparison to healthy controls. In comparisons between diseases, ASCA IgG was positive in significantly more patients with CD (P<0.001) and IT (P<0.001) in comparison to UC. There was no significant difference in ASCA IgA (33.9% vs. 43.3%), ASCA IgG (50.86% vs. 46.6%), or ANCA (10.7%, 7.4%) in patients with CD and IT, respectively. There was no correlation between ASCA and duration, location and behavior of CD, and IT. We conclude that ASCA IgG and ASCA IgA do not help to differentiate between IT and CD.

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Frequency of ASCA Seropositivity in Children with Cystic Fibrosis

Cited by 27 publications

References 18 publications

Prevalence and clinical significance of auto-antibodies in adults with cystic fibrosis

Prevalence and clinical significance of auto-antibodies in adults with cystic fibrosis

The Cystic Fibrosis Intestine

Anti-Saccharomyces cerevisiae Antibody Does Not Differentiate Between Crohn's Disease and Intestinal Tuberculosis

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