Frequency of bacteremia in patients with sickle cell disease: a longitudinal study

Al‐Tawfiq, Jaffar A.; Rabaan, Ali A.; Al-Edreesi, Mohammed

doi:10.1007/s00277-021-04523-x

Cited by 6 publications

(4 citation statements)

References 24 publications

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“…Among 67 cases with sepsis, 54 (79.1%) were culture-proven, with 11 (20.7%) patients, showing multiple microorganisms, while bacterial, fungal, and viral microorganisms were isolated in 32 (60.4%), 6 (11.3%), and in 4 (7.5%) respectively. The most frequent organisms were gram-negative organisms, similar to the recent report of the rising gram-negative organisms, reflecting an increasing use of external lines and acquisition of hospital acquired infections 43 .…”

Section: Discussionsupporting

confidence: 84%

Multi-center study on mortality in children, and adults with sickle cell anemia-risk factors and causes of death

Alkindi,

Al-Jadidi,

Al-Adawi

et al. 2024

Sci Rep

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Sickle cell disease (SCD) is a major public health burden worldwide with increasing morbidity and mortality. The study evaluates the risk factors associated with mortality in SCD patients, between the years 2006 and 2020 at three hospitals in Oman. The analysis includes clinical manifestations, haematological, biochemical, and radiological parameters, use of antibiotics, and blood and exchange transfusions. Our cohort included 123 patients (82 males, 41 females), with a median age of 27 (Interquartile Range 21–35 years). SCD related complications included acute chest syndrome (ACS) in 52.8%, splenic sequestration in 21.1%, right upper quadrant syndrome in 19.5%, more than > 6 VOC/year in 17.9%, and stroke in 13.8%. At the terminal admission, patients had cough, reduced O2 saturation, crepitation and fever in 24.4%, 49.6%, 53.6% and 68.3% respectively. Abnormal chest X-ray and chest CT scan were seen in 57.7%, and 76.4% respectively. Laboratory parameters showed a significant drop in hemoglobin (Hb) and platelet counts from baseline, with a significant rise in WBC, LDH and CRP from baseline (p < 0.05, Wilcoxon Signed Ranks test). All patients received antibiotics, whereas, 95.9% and 93.5% received simple blood transfusions, and exchange transfusions respectively, and 66.6% required non-invasive ventilation. Among the causes of death, ACS is seen in 32 (26%), sepsis in 49 (40%), and miscellaneous in 42 (34%). Sudden death was seen in 32 (26%) of patients. Male gender, with low HbF, rapid drop in Hb and platelet, and increased in WBC, LDH, ferritin, and CRP, correlated significantly with mortality in this cohort.

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Section: Discussionsupporting

confidence: 84%

Multi-center study on mortality in children, and adults with sickle cell anemia-risk factors and causes of death

Alkindi,

Al-Jadidi,

Al-Adawi

et al. 2024

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Among 67 cases with sepsis, 54 (79.1%) were culture-proven, with 11 (20.7%) patients, showing multiple microorganisms, while bacterial, fungal, and viral microorganisms were isolated in 32 (60.4%), 6 (11.3%), and in 4 (7.5%) respectively. The most frequent organisms were gram-negative organisms, similar to the recent report of the rising gram-negative organisms, re ecting an increasing use of external lines and acquisition of hospital acquired infections [42].…”

Section: Discussionsupporting

confidence: 83%

Multi-center study on mortality in children, and adults with sickle cell anemia-risk factors and causes of death

Alkindi

Al-Jadidi

Al-Adawi

et al. 2023

Preprint

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Sickle cell disease (SCD) is a major public health burden worldwide with increasing morbidity and mortality. We studied the risk factors associated with mortality in SCD patients, between the years 2006 and 2020 at three hospitals in Oman. We analyzed clinical manifestations, haematological, biochemical, and radiological parameters, use of antibiotics, and blood and exchange transfusions. Our cohort included 123 patients (82 males, 41 females), with a median age of 27 (IQ 21–35 years). SCD related complications included acute chest syndrome (ACS) in 52.8%, splenic sequestration in 21.1%, right upper quadrant syndrome in 19.5%, more than > 6 VOC /year in 17.9%, and stroke in 13.8%. At the terminal event, patients had cough, reduced O2 saturation, crepitation and fever in 24.4%, 49.6%, 53.6% and 68.3% respectively. Abnormal chest x-ray and chest CT scan were seen in 57.7%, and 76.4% respectively. Laboratory parameters showed a significant drop in hemoglobin (Hb) and platelet counts from baseline, with a significant rise in WBC, LDH and CRP from baseline (p < 0.05, Wilcoxon Signed Ranks test).. All patients received antibiotics, whereas, 95.9% & 93.5% received simple blood transfusions, and exchange transfusions respectively, and 66.6% required non-invasive ventilation. Among the causes of death, ACS is seen in 32 (26%), sepsis in 49 (40%), and miscellaneous in 42 (34%). Sudden death was seen in 32 (26%) of patients. Male gender, with low HbF, rapid drop in Hb and platelet, and increased in WBC, LDH, ferritin, and CRP, correlated significantly with mortality in this cohort.

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“…A incidência de infecção bacteriana em crianças com DF mundialmente é de 16% e progride causando doenças de alto risco de vida em 10-25% Brazilian Journal of Health Review, Curitiba, v. 6, n. 4, p. 18603-18619, jul/aug., 2023 desses pacientes. Além disso, infecções virais também acometem frequentemente esses pacientes, sendo que aproximadamente 6,7% dessas viroses evoluem para síndrome torácica aguda, outra complicação comum da AF (ALKIND et al, 2020;TAWFIQ;RABAAN;ALEDREESI, 2021;ALZAHRANI et al, 2021;OCHOCINSKI et al, 2020).…”

Section: Infecçõesunclassified

Incidência e manejo das urgências clínicas de pacientes portadores de anemia falciforme

Conte,

De Souza,

Figueira

et al. 2023

Braz. J. Hea. Rev.

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O presente artigo teve como objetivo, por meio de uma revisão de literatura, apresentar as principais complicações na anemia falciforme, abordando sua incidência e manejo clínico. A anemia falciforme é caracterizada pela substituição do ácido glutâmico pela valina na posição 6 da cadeia de β-hemoglobina, criando uma molécula de hemoglobina com funcionalidade anômala, chamada hemoglobina S, podendo levar a hemácia a apresentar formato de “foice” e tempo de meia vida limitado. As frequentes hospitalizações provenientes dos agravos fisiopatológicos da anemia falciforme vão desde dor importante, infecções e a quadros graves, por exemplo, a crise do sequestro esplênico, o acidente vascular cerebral e a crise aplásica, que necessitam de acompanhamento em unidade de terapia intensiva e tratamentos de maior complexidade, como transfusões sanguíneas ou até mesmo transplante de medula óssea. Fatores como estes mostram a relevância da identificação e do manejo adequado das agudizações, a fim de propiciar sobrevida e qualidade de vida aos indivíduos com a anemia falciforme.

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Frequency of bacteremia in patients with sickle cell disease: a longitudinal study

Cited by 6 publications

References 24 publications

Multi-center study on mortality in children, and adults with sickle cell anemia-risk factors and causes of death

Multi-center study on mortality in children, and adults with sickle cell anemia-risk factors and causes of death

Multi-center study on mortality in children, and adults with sickle cell anemia-risk factors and causes of death

Incidência e manejo das urgências clínicas de pacientes portadores de anemia falciforme

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