Frequency of Beta Thalassemia and Iron Deficiency Anemia in Moderate Anaemic Pregnant Patients Visiting to Tertiary Care

Zulfiqar, Bushra

doi:10.19080/bboaj.2017.02.555593

Cited by 2 publications

(1 citation statement)

References 11 publications

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“…The World Health Organisation (WHO) figures estimate a total of 5% of the world population as a carrier of Hemoglobin disorders, with the cumulative gene frequency of hemoglobinopathies in India estimated to be 4.2% with a population of over 1.2 billion and over 12,000 infants born each year with a clinically significant hemoglobinopathy. 1,2 Dr. Reshmi Shrestha, MD ORCID ID: 0000-0002-9914-9213 Email: reshmishrestha2070@gmail.com This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.…”

Section: Introductionmentioning

confidence: 99%

Utility of basic hematological indices in early detection of hemoglobinopathies in paediatric population of southern India.

VM,

2023

J Pathol Nep

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Background: Cases diagnosed as Microcytic Hypochromic Anaemia in paediatric age group will be subjected to basic hematological indices and further confirmed in cases of high suspicion through Hemoglobin Electrophoresis and High-Performance Liquid Chromatography. This study aimed to identify simple indices and cost-effective methods to detect undiagnosed cases of thalassemia syndromes being treated for nutritional deficiency anemias. Materials and Methods: The study included 100 pediatric patients, from a period of January 2018 to June 2020. Case selection was based on children whose hemoglobin levels were below the cutoff value according to age. They were further subjected to Sehgal’s and Mentzer’s indices and suggestive cases were subjected to Gel Electrophoresis (Both Alkaline and Acid) and High-Performance Liquid Chromatography. Results: 43% of the cases showing abnormality on screening hematological indices were further subcategorized on gel electrophoresis and confirmed on HPLC. 27% of the cases were diagnosed to be β Thalassemia Trait, which constituted the most frequent type of hemoglobinopathy detected. There were 8% of the cases diagnosed to be as Sickle Cell disease which included major and minor forms. 5% of the study cases were diagnosed as β Thalassemia major. 3% of the cases were diagnosed as HbE disease, HbE trait and ȣβ Thalassemia. Conclusions: Hematological indices can be used effectively for early detection of suspected cases of hemoglobinopathies.

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Section: Introductionmentioning

confidence: 99%

Utility of basic hematological indices in early detection of hemoglobinopathies in paediatric population of southern India.

VM,

2023

J Pathol Nep

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“Prevalence of Beta-Thalassemia Trait in Pregnant Women Attending Antenatal Clinic”

Jain¹,

Gupta²,

Sengar

2021

PIJR

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INTRODUCTION- Iron deficiency anemia and thalassemia syndromes,especially beta thalassemia trait (BTT),are the two most commonly ccuring microcytic hypochromic anemias highly prevalent in countries like India. Iron deficiency anemia is the first most common cause of anemia in pregnancy,beta thalassemia trait is the second most frequent cause of anemia of pregnancy. Patients with thalassemia trait shows an increased incidence of anemia during the second trimester of pregnancy. Beta Thalassemia Trait (BTT) patients are usually asymptomatic and ignorant of their carrier state unless diagnosed by testing. Screening for thalassemia can be done by measuring HbA2 levels MATERIAL AND METHOD- This is a retrospective study. The data were collected from a clinic and associated st pathology in Shivpuri and a private maternity hospital in Gwalior from 1 January 2019 to 30 June 2021.94 patients were included in the study.All pregnant women between the age of 18-45 years and at any gestational age with hemoglobin level <10g/dL and microcytic hypochromic anemia (report of CBC) were included in the study. High-Performance Liquid Chromatography (HPLC) and serum ferritin report were collected. RESULTS- In our study the most common age group in which the anemia was found between 19-35 years (80.85%).Most of the patients were primigravida (44.68%),between 26-37 wks of gestational age (82.97%),from a rural area (70.21%). Only 2 patients had a family history (2.12%) of beta-thalassemia and 6 patients had a history (6.38%) of blood transfusion. In our study moderate anemia was found in 55.31% of cases followed by mild anemia 25.53% and severe anemia 19.14%. In our study iron deficiency anemia was found in 87.23% only minor Beta-thalassemia was found to be 4.25%, of the patient,and the coexistence of iron deficiency anemia and beta-thalassemia in pregnant women is 8.51%. In our study total of 12 patients (4 cases of only minor beta-thalassemia and 8 cases of minor beta-thalassemia associated with IDA) The prevalence rate of beta-thalassemia in our study was 7.8%. CONCLUSION- the recommendation is to diagnose beta-thalassemia in pregnant patients is essential to give proper treatment.The screening of pregnant patients prevents unnecessary parental iron therapy and iron overload in case of anemia.further studies are needed in this field and less expensive and accurate methods should come in place.

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Frequency of Beta Thalassemia and Iron Deficiency Anemia in Moderate Anaemic Pregnant Patients Visiting to Tertiary Care

Abstract: Objective: To screen out the moderate anemic patients for iron deficiency anemia, β-thalassemia or combined iron deficiency anemia & β-thalassemia.

Cited by 2 publications

References 11 publications

Utility of basic hematological indices in early detection of hemoglobinopathies in paediatric population of southern India.

Utility of basic hematological indices in early detection of hemoglobinopathies in paediatric population of southern India.

“Prevalence of Beta-Thalassemia Trait in Pregnant Women Attending Antenatal Clinic”

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