Frequency of Chemotherapy Induced Anemia in Breast Cancer Patients

Pourali, Leila; Taghizadeh, Ali; Akhoundi, M; Varshoei, Fatemeh; Zarifian, Ahmadreza; Andalibi, Mohammad Sobhan Sheikh

doi:10.17795/ijcp-4672

Cited by 17 publications

(25 citation statements)

References 18 publications

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“…The reason for the large number of patients in anemic population may be also due to considering the WHO scale for anemia in non-pregnant females. The highest rate of anemia in post chemotherapy patients was observed in stage 3 with 59.32% followed by stage 4 in 31.36%.this finding was consistent with the results of Pourali et al 15 who also had the highest rate of anemia in patients with stage 3 tumour (56.9%). This might be due to the fact that most of our patients were diagnosed at higher stages (59.2% in stage 3 and 32% in stage 4), which affects the sampling in such a way that none of the patient was with low-stage breast tumour in the study.…”

Section: Discussionsupporting

confidence: 90%

Transfusion Requirement in Anemia observed in Patients with Carcinoma Breast undergoing Chemotherapy

Nair¹,

Sasikala²,

Meena³

et al. 2019

IJCMR

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Introduction: Carcinoma Breast is the second most common malignancyaffecting women. Adjuvant chemotherapy is the mainstay treatment modality along with surgery. Anemia and thrombocytopenia are the hematological complications in patients with breast cancer who undergo chemotherapy. This study was carried out with an objective to identify the proportion of anemia and the requirement of Packed Red Cells transfusions in these patients. Material and methods: This is ahospital based prospective study, done for a period of one and a half years from January 2016 to June 2017.As per the inclusion criteria125 consecutive cases who underwent chemotherapy for Carcinoma Breast at Department of Radiotherapy, Govt. Medical College, Thiruvananthapuram were included for the study. The requirement of Packed Red Cell (PRC) was assessed in these patients. Data was analysed with SPSS software (version 21). Results: Among the 125 patients, 60% of patients were anemic in prechemotherapyphase with a preponderance of mild anemia,haemoglobin (Hb) 11-11.9gm/dl (as per the WHO classification of anemia in non pregnant females). Inpost chemotherapy phase the prevalence of anemia was 94.4% withincreasing severity; majority (56%) of patients had moderate anemia (Hb 8-10.9gm/dl). During chemotherapy, 22.4% of the study population required PRC transfusion. Conclusion: Due to the high prevalence of chemotherapyinduced anemia and itseffects on quality of life (QOL), even mild degrees of anemia should be detected and evaluated before commencing chemotherapy. PRC transfusion should be reserved for patients with severe anemia.

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Section: Discussionsupporting

confidence: 90%

Transfusion Requirement in Anemia observed in Patients with Carcinoma Breast undergoing Chemotherapy

Nair¹,

Sasikala²,

Meena³

et al. 2019

IJCMR

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“…The age ranged from 25 to 80 years with the median of 52 years. The age of study population is in concordance with the study done by Pourali et al 15 Majority of women were postmenopausal (n= 71, 56.8%) and majority were in the overweight category (n=55, 44%) while 24.8% patients were in obese category, which is considered as a risk factor for carcinoma breast. Tumour sized > 5 cm (T3) had the most prevalence among (n=74, 59.8%) patients.…”

Section: Methodssupporting

confidence: 88%

Transfusion Requirement in Thrombocytopenia Observed in Patients with Carcinoma Breast Undergoing Chemotherapy

Nair¹,

Sasikala²,

Meena³

et al. 2019

IJCMR

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Introduction: Breast cancer is the commonest cancer in urban Indian females, and the second commonest in the rural Indian women. The estimated number of breast cancer cases in India during 2012 was 145,000 cases with an incidence rate of 25.8 per 100,000 women. In Kerala, Breast cancer has an annual incidence of 14.9/100,000 population. This study was carried out with an objective to identify the proportion of thrombocytopenia and the requirement of platelet transfusions in these patients. Material and methods: This was a hospital based prospective study, done in the Department of Transfusion medicine for a period of one and a half years from January 2016 to June 2017. As per the inclusion criteria 125 consecutive cases who underwent chemotherapy for Carcinoma Breast at Department of Radiotherapy, Govt. Medical College, Thiruvananthapuram were included for the study. The requirement of platelet transfusions were assessed in these patients. Data was analysed with SPSS software (version 21). Results: Among the 125 patients, thrombocytopenia was noticed in 5.4% study population in prechemotherapy phase, majority having only grade I thrombocytopenia. In Post chemo phase thrombocytopenia was observed in 11.2% of the study group, grade I thrombocytopenia in 8.8% and grade II thrombocytopenia 2.4% of patients. Platelet transfusion was required in 5.4% of the patients during chemotherapy. Conclusion: Due to the high prevalence of chemotherapyinduced hematological complications, even mild degrees of thrombocytopenia should be detected and evaluated before commencing chemotherapy. Platelet transfusion should be reserved for patients who were really required. This study gives an insight regarding the proportion of thrombocytopenia in patients with carcinoma breast undergoing chemotherapy and their platelet transfusion requirements, which will help in taking care of these patients and inventory management of the blood banks.

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“…Pourali L. (5) and colleagues mentioned that prevalence and severity of anaemia among breast cancer patients in their advanced stages have been well documented, but the same cannot be said those amongst those in the earlier stages. Hence signifying the value of this study as it focuses on detection and evaluation of anti-anaemic treatment among breast patients across various stages (5). Imran M et al, (23) whom conducted a study amongst female breast cancer patients in Saudi Arabia to assess their QOL mentioned that there was a direct relationship between choice of treatments used for breast cancer patients, side effects, medical issues, and QOL.…”

Section: Discussionmentioning

confidence: 93%

“…Incidence of anaemia in cancer patients was reported to be 41% before receiving chemotherapy but increased to 43.1% upon anti-neoplastic therapy (5). ).…”

Section: Introductionmentioning

confidence: 99%

Impact and Association of Anaemia Severity and Its Treatment With Quality of Life of Breast Cancer Patients in Malaysia

Muthanna

Hassan

Mohammed

et al. 2021

Preprint

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Purpose This study aimed to assess the level of anaemia severity, evaluate the current treatment practice of anaemia, and to determine the association between anaemia level and its management on quality of life of breast cancer patients in Malaysia. Methods A prospective study design was conducted among breast cancer patients in multicancer centers in Malaysia including three follow ups. Clinical data were collected from their medical records and at each follow up, they were required to fill in a functional assessment chronic therapy (FACT-An) questionnaire. Descriptive and inferential statistical analysis were done using SPSS. Results Out of 120 participants, 32% received anaemia treatment. Out of 32% who received anti-anaemic medication, the majority of patients (87%) were prescribed with iron supplementation and only 13% received combination of blood transfusion and iron therapy and no one received erythropoietin stimulating agents (ESAs). Findings reported that the curve of the mean of QOL score and Hb level significantly declined across the three follow-ups (p<0.005). Statistical tests also indicated a significant association between anti-anaemic treatments with haemoglobin level and QOL scores. However, this association was insufficient to significantly improve QOL or palliate anaemia severity among participants.Conclusion There is still a lot of gaps to improve in the management of anaemia among breast cancer patients to show a significant improvement in haemoglobin level. Therefore, respective organisations and oncologists are required to raise awareness about the optimal treatment of anaemia among breast cancer patients, as a result, improve general wellbeing of them.

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Frequency of Chemotherapy Induced Anemia in Breast Cancer Patients

Cited by 17 publications

References 18 publications

Transfusion Requirement in Anemia observed in Patients with Carcinoma Breast undergoing Chemotherapy

Transfusion Requirement in Anemia observed in Patients with Carcinoma Breast undergoing Chemotherapy

Transfusion Requirement in Thrombocytopenia Observed in Patients with Carcinoma Breast Undergoing Chemotherapy

Impact and Association of Anaemia Severity and Its Treatment With Quality of Life of Breast Cancer Patients in Malaysia

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