Frequency of coexistent carcinoma in sessile serrated adenoma/polyps and traditional serrated adenomas removed by endoscopic resection

Saiki, Hirotsugu; Nishida, Tsutomu; Yamamoto, Masashi; Hayashi, Shiro; Shimakoshi, Hiromi; Shimoda, Akiyoshi; Amano, Takahiro; Sakamoto, Aisa; Otake, Yuriko; Sugimoto, Aya; Takahashi, Kei; Mukai, Kaori; Matsubara, Tokuhiro; Nakajima, Sachiko; Fukui, Koji; Inada, Masami; Yamamoto, Katsumi; Tokuda, Ryozo; Adachi, Shiro

doi:10.1055/s-0042-103239

Cited by 16 publications

(20 citation statements)

References 26 publications

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“…Some studies have revealed that the proximal large serrated lesion is an important risk factor for CRC . Recent studies have suggested that a number of proximal serrated polyps may be missed during colonoscopy, and the missing rate of proximal serrated lesions using white light endoscopy is higher than using chromoendoscopy. In addition, SSA/P observed during screening colonoscopy were mostly flat or sessile, whereas 38% of TSAs were found to present with flat morphology .…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological features of advanced colorectal serrated lesions: A single‐center study in China

Liu

Jin

Khan

et al. 2018

J of Digest Diseases

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Section: Discussionmentioning

confidence: 99%

Clinicopathological features of advanced colorectal serrated lesions: A single‐center study in China

Liu

Jin

Khan

et al. 2018

J of Digest Diseases

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“…Saiki et al reported that the frequencies of HPs, SSA / Ps, and TSAs in a Japanese population were 5.3 , 3.0 , and 0.6 of all resected colorectal polyps in a retrospective analysis 18 .…”

Section: Discussionmentioning

confidence: 99%

Accuracy of the Differential Diagnosis of Colorectal Serrated Polyps Using a Conventional Endoscope: A Prospective Study

Yanagisawa

Kubota

Konishi

et al. 2017

Showa Univ J Med Sci

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: Some serrated polyps SPs are thought to be precursors of colorectal cancers. However, the endoscopic diagnosis of sessile serrated adenoma / polyps SSA / Ps has been reported to have a low accuracy. The aim of this study was to clarify the ability to distinguish between SSA / Ps and non-SSA / Ps by using mucosal crypt patterns combined with endoscopic ndings. In total, 457 consecutive patients who underwent endoscopic resection for colorectal polyps at the Showa University Hospital from April 2007 to December 2010 were prospectively enrolled in this study. Before treatment, mucosal crypt patterns of the lesions were classi ed into three types hyperplastic, adenomatous, and mixed pattern . When the lesion had an adenomatous pattern with a cerebriform appearance or mixed pattern, it was diagnosed as a traditional serrated adenoma TSA . If the lesion had a hyperplastic pattern and was sized 6 mm or more in the proximal colon or 10 mm or more in the distal colon, it was diagnosed as an SSA / P by the endoscopist. We analyzed 1,151 colorectal polyps in this study. Endoscopically, 117 polyps were diagnosed as SSA / Ps or hyperplastic polyps HPs , 998 polyps were conventional adenomas, and 36 polyps were TSAs, with diagnostic accuracies of 94.7 , 94.1 , and 97.3 , respectively. Of the 117 polyps diagnosed as SSA / Ps or HPs, 59 lesions met our criteria for SSA / Ps, with a diagnostic accuracy of 70.9 . Our results indicate that the combination of mucosal crypt patterns and endoscopic findings may be useful for differentiating between SPs and non-SPs. However, additional speci c endoscopic features of SSA / Ps are still needed.

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“…Polypoid TSA are detected more frequently in men and they are less likely to progress to CRC as compared with women [36].…”

Section: Classifi Cation Of Serrated Polypsmentioning

confidence: 97%

Serrated polyps as precursor lesions of colorectal cancer: current status and future directions. Mini-review.

Kuzo

2016

Patologìâ

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Early diagnosis of colorectal cancer (CRC) is a very urgent problem, since this disease has second place among women and the third one among men in the structure of cancer pathology. According to recent data, CRC should be considered as a heterogeneous multifactorial family of diseases with different variants.Serrated polyps of the colon are obligate precancerous condition, which can transform into cancer due to genetic aberrations. Serrated polyps are a heterogeneous group of formations with different ways of appearance and potential malignancy. They are divided into major subtypes: hyperplastic polyps, sessile serrated adenoma/polyp and traditional serrated adenoma.The purpose of the study was the analysis of current data about mechanisms of formation and malignization of serrated colonic polyps.The relationship between the localization of serrated polyps and their morphology was identifi ed. Polyps located in the proximal colon are characterized by a more expressed degree of serration in the basal segment of crypts compared with polyps located in the distal part of the colon. The difference between the proximal and distal localization was confi rmed by molecular genetic testing: the majority of proximal serrated polyps develops after BRAF mutations, and the majority of polyps with distal localization develops after a KRAS mutation.It is known that a key role in the excessive proliferation and inhibition of apoptosis in the process of malignant transformation of serrated polyps is provided by the combination of different types of genome damage, both genetic and epigenetic. Molecular changes are already present in the early stages of cell dysplasia in serrated colon polyps, and their nature determines the malignant potential.Conclusions. A thorough study of the molecular mechanisms of progression along the serrated pathway and transformation of serrated polyps in the CRC opens up prospects for the development of guidelines for patient management in order to prevent the development of serrated pathway cancers. Зубчасті поліпи як прекурсор розвитку раку товстої кишки: сучасний погляд і перспективи. Міні-огляд І. О. КузьоСвоєчасна діагностика раннього раку товстої кишки є вкрай актуальним питанням сучасності, оскільки це захворювання посідає друге місце серед жінок і третє серед чоловіків у структурі онкологічної патології. Згідно з результатами останніх досліджень, рак товстої кишки слід розглядати як гетерогенну, мультифактор-зумовлену групу захворювань із різними варіан-тами перебігу.Зубчасті поліпи товстої кишки є облігатним передраковим станом. У зв'язку з цим у світі активно вивчаються молекуляр-но-генетичні та імуноморфологічні аспекти їхнього злоякісного потенціалу. Сьогодні дослідники визнають: зубчасті поліпи товстої кишки можуть малігнізуватися шляхом послідовної трансформації, що зумовлена генетичними абераціями.Мета роботи -аналіз сучасних даних щодо механізмів формування та малігнізації зубчастих поліпів товстої кишки. Зубчасті поліпи є гетерогенною групою утворень, що мають різні шляхи розвитку та з...

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Frequency of coexistent carcinoma in sessile serrated adenoma/polyps and traditional serrated adenomas removed by endoscopic resection

Cited by 16 publications

References 26 publications

Clinicopathological features of advanced colorectal serrated lesions: A single‐center study in China

Clinicopathological features of advanced colorectal serrated lesions: A single‐center study in China

Accuracy of the Differential Diagnosis of Colorectal Serrated Polyps Using a Conventional Endoscope: A Prospective Study

Serrated polyps as precursor lesions of colorectal cancer: current status and future directions. Mini-review.

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