Frequency of combined hepatic and pancreatic steatosis

Byelyayeva, N. V.; Губергриц, Н. Б.; Лукашевич, Г. М.

doi:10.1016/j.pan.2021.05.294

Cited by 1 publication

(4 citation statements)

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“…Subsequently, 85 articles underwent the second round of review. Finally, 26 observational studies comprising a total of 67 803 patients were included in the analysis: 4 case-control studies and 22 cross-sectional studies [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24]26,[28][29][30][31][32][33][34]41,42]. No longitudinal cohort studies reporting the outcomes of interest were identified.…”

Section: Study Selectionmentioning

confidence: 99%

“…The meta-analysis of the 19 included studies [11,12,[14][15][16][17]19,[21][22][23][24]26,[29][30][31][32][33]41,42] is presented in Fig. 2.…”

Section: Association Of Nafld With the Risk Of Fatty Pancreasmentioning

confidence: 99%

“…Of the 26 articles, 24 were full-text articles, and two were conference abstracts. Nineteen studies, involving a total of 52 723 subjects, reported the odds of fatty pancreas in patients with and without NAFLD [11,12,[14][15][16][17]19,[21][22][23][24]26,[29][30][31][32][33]41,42]. Three articles, with a total of 802 patients, evaluated the odds of NAFLD in patients with and without fatty pancreas [13,28,34].…”

Section: Study Selectionmentioning

confidence: 99%

“…Age, sex, ethnicity, unhealthy lifestyle, and metabolic disorders have been recognized as the common risk factors for fatty pancreas [3,7,9]. Growing evidence has shown associations between fat content in the pancreas and the liver, suggesting a potential relationship between fatty pancreas and NAFLD [10–34]. Some research has discovered evidence that fatty pancreas contributes to fat accumulation in the liver, potentially accelerating the progression of NAFLD [18].…”

Section: Introductionmentioning

confidence: 99%

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Bidirectional association between non-alcoholic fatty liver disease and fatty pancreas: a systematic review and meta-analysis

Wongtrakul,

Untaaveesup,

Pausawadi

et al. 2023

European Journal of Gastroenterology &Amp; Hepatology

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Background Accumulating evidence suggests a potential relationship between non-alcoholic fatty liver disease (NAFLD) and fatty pancreas, as both conditions are associated with fat deposition in the liver and pancreas, respectively. The meta-analysis aimed to investigate the bidirectional association between NAFLD and fatty pancreas, as well as their respective effects on disease severity. Methods A systematic search of the EMBASE and MEDLINE databases, from inception to August 2022, was conducted to identify observational studies examining the association between NAFLD and fatty pancreas, as well as their impact on disease severity. The pooled odds ratio (OR) with a 95% confidence interval (CI) was estimated using a random-effects model. Results Our analysis included 26 case-control or cross-sectional studies, comprising 67,803 participants. We observed a significant association between NAFLD and an increased odds of having fatty pancreas (OR, 6.18; 95% CI, 4.49–8.51; I2 = 92%). Similarly, fatty pancreas was significantly associated with an increased odds of having NAFLD (OR, 9.56; 95% CI, 5.09–17.95; I2 = 83%). Furthermore, the presence of fatty pancreas was associated with a 1.75-fold increased risk of severe NAFLD based on ultrasonographic classification (95% CI, 1.46–2.10; I2 = 0%). Among NAFLD patients, the coexistence of fatty pancreas was associated with a trend towards increased odds of having non-alcoholic steatohepatitis (OR, 3.52; 95% CI, 0.65–18.93; I2 = 82%) and advanced fibrosis (OR, 2.47; 95% CI, 0.52–11.80; I2 = 76%). Conclusion This meta-analysis discloses a bidirectional association between NAFLD and fatty pancreas, emphasizing the importance of understanding the intricate relationship between these two conditions.

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