Frequency of delta F508 in a Mexican sample of cystic fibrosis patients.

Analysis of 16 cystic fibrosis mutations in Mexican patients

“…The frequency of the ⌬F508 mutation found in this study (45%) is slightly lower than that reported in Spain (60%) [Chillón et al, 1990;Peral et al, 1991] and other European Mediterranean countries (55%) [Nunes et al, 1991], and similar to that found for Latin Americans living in the US (45%) [Grebe et al, 1994;CFGAC, 1994]. The frequency of the ⌬F508 mutation in a previous report of Mexican CF patients of Central Mexico (39%) [Orozco et al, 1993] is similar to the value found in our study.…”

“…Recently, molecular genetic studies were initiated in Latin American populations [Rojas et al, 1992;Orozco et al, 1993]. In Mexico there is a fusion of two ethnic groups which began 500 years ago with the arrival of the Spaniards.…”

The ?F508 mutation in Ecuador, South America

“…The incidence of ∆F508 [Orozco et al, 1993] in Mexico; 50.8% in Brazil [Maróstica et al, 1998]; 57% [Chertkoff et al, 1997] to 60.9% [Luna et al, 1996] in Argentina; and 46% in Hispanics [Grebe et al, 1994]. The incidence found in Argentina and Brazil is not comparable to the rest of Latin American because of the different origin of their populations.…”

Cystic fibrosis in Uruguay

“…It was 47-48.4% among Brazilians (Raskin et al, 1993;Bernardino et al, 2000) but significant interstate differences (27-53%) were observed (Raskin et al, 1993). Only 29.2% of the CF chromosomes in the Chilean population carry ∆F508 (Ríos et al, 1994), and the frequency of this mutation in the Mexican population is about 39% (Orozco et al, 1993). Finally, in Argentina, whose population is ethnically similar to Uruguay, 57% of the analyzed CF chromosomes carry the ∆F508 deletion (Chertkoff et al 1997).…”

“…Little has been published on cystic fibrosis in Latin America (Valenzuela, 1988;Raskin et al, 1993;Orozco et al, 1993;Ríos et al, 1994;Chertkoff et al, 1997). It is difficult to compare the known populations to that of Uruguay due to differences in ethnic compositions.…”