Frequency of detection of respiratory viruses in the lower respiratory tract of hospitalized adults

Minosse, Claudia; Selleri, Marina; Zaniratti, Maria S.; Cappiello, Giuseppina; Longo, Roberta; Schifano, E.; Spanò, A.; Petrosillo, Nicola; Lauria, F.; Puro, Vincenzo; Capobianchi, Maria Rosaria

doi:10.1016/j.jcv.2008.01.012

Cited by 28 publications

(34 citation statements)

References 43 publications

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“…Increasing evidence suggests that virus infection in LRTI patients has been underestimated [3,15,30,31,32,33,34,35]. Our data are in agreement with previous studies which were based on virus isolation and culture from bronchoalveolar lavage samples, PCR results from throat swabs and/or serology [3,36,37].…”

Section: Discussionsupporting

confidence: 92%

Single and Multiple Viral Infections in Lower Respiratory Tract Infection

Gencay¹,

Roth²,

Müeller

et al. 2010

Respiration

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Background: Lower respiratory tract infection (LRTI) often leads to hospitalization, and it was indicated that causative viral infections are underestimated. Objectives: It was our aim to compare the frequency of 8 relevant viruses in 109 hospitalized LRTI patients and 144 healthy controls. Methods: Virus infection was determined by seroconversion and ELISA for anti-virus antibodies in repeated serum samples. Bacterial infection was diagnosed in respiratory specimens, blood cultures and urine. Results: The LRTI patient cohort consisted of 49 patients with community-acquired pneumonia, 30 patients with acute bronchitis and 30 chronic obstructive pulmonary disease patients with acute exacerbation. Viral infection was detected in 89 (82%) LRTI patients compared with 32 (22%) in healthy controls (relative risk 3.42, 95% confidence interval 2.48–4.72; p < 0.0001). The most frequent viral pathogens were: influenza B (23%), adenovirus (16%) and parainfluenza virus 3 (12%). Importantly, infections with more than 1 virus were detected in 63% (n = 57) of LRTI patients with viral infection, which represents 52% of all LRTI patients. No multiple virus infection was detected in the healthy controls. Patients with community-acquired pneumonia were more often infected with adenovirus and respiratory syncytial virus as compared with the other LRTI patients (p = 0.046 and 0.0009, respectively). Conclusions: There is a high incidence of single and multiple viral infections in LRTI patients requiring hospitalization. The data indicate the need for regular virus diagnosis and the development of point of care tools that enables a fast diagnosis of the most common viruses and bacteria. The data also imply the need to consider antiviral therapy in positive LRTI cases.

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Section: Discussionsupporting

confidence: 92%

Single and Multiple Viral Infections in Lower Respiratory Tract Infection

Gencay¹,

Roth²,

Müeller

et al. 2010

Respiration

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“…The importance of the specimen type is highlighted in several studies. In BAL specimens a diagnostic yield ranging from 3.6% to 32.0% was reported [15][16][17]. Soccal et al evaluated paired nasopharyngeal and BAL fluid specimens and observed an overall viral positivity rate of 29.3% in the upper respiratory tract specimens and 17.2% in the BAL samples (P < 0.001) [18].…”

Section: Discussionmentioning

confidence: 99%

Clinical evaluation of a multi-parameter customized respiratory TaqMan ® array card compared to conventional methods in immunocompromised patients

Steensels

Descheemaeker

Curran

et al. 2015

Journal of Clinical Virology

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“…The frequency of respiratory viral infections (RVIs) in immunocompetent adults is often overlooked; however, available data suggest that RVIs are responsible for a significant number of respiratory infections affecting not only the elderly (persons aged ≥65 years) but also young adults. 12,13,[27][28][29][30][31][32] Although the majority of infections in young adults are not life-threatening they can impose a significant burden on communities since the affected population represents a large fraction of the work force in developing countries. Data presented in this report indicate that 65.1% (28/43) of virus-positive samples were detected in patients <60 years of age.…”

Section: Discussionmentioning

confidence: 99%