Frequency of development of aspirin resistance in the early postoperative  period and inadequate inhibition of thromboxane A2 production  after coronary artery bypass surgery

Özkan, Hayrettin; Kiriş, İlker; Gülmen, Şenol; Okutan, Hüseyin; Solmaz, Filiz Alkaya; Kara, Kenan Abdurrahman

doi:10.5606/tgkdc.dergisi.2018.15489

Cited by 3 publications

(3 citation statements)

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“…However, the variation in the pharmacodynamics of aspirin is greater than the variation in that of ticagrelor, which is correlated with aspirin metabolism-associated SNPs such as PEAR1 and GP1BA SNPs [ 10 ]. ACA-induced platelet aggregation is typically an indicator of aspirin pharmacodynamics [ 11 , 12 ]. The significant difference in the ACA-induced platelet aggregation rate between the patients with and without bleeding events suggests that aspirin is the determinant cause of bleeding when used in combination with ticagrelor.…”

Section: Discussionmentioning

confidence: 99%

Lower Platelet Aggregation Is a Risk Factor for Dual Antiplatelet Therapy-Associated Bleeding: A Preliminary Retrospective Study with Genotype Analysis

et al. 2020

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Background The purpose of this study was to investigate factors influencing bleeding in patients with acute coronary syndrome (ACS) who are on aspirin and ticagrelor as dual antiplatelet therapy. Material/Methods This retrospective case-control study included 50 patients with ACS (25 with reported bleeding events and 25 without) on aspirin and ticagrelor. Adenosine diphosphate (ADP)- and arachidonic acid (ACA)-induced platelet aggregation rates were measured using light transmission aggregometry. Single-nucleotide polymorphisms (SNPs) in PEAR1 , GP1BA , and GSTP1 were genotyped. Results ACA-induced platelet aggregation rates were obviously lower in patients with bleeding events than in those without (13.28±8.46% vs. 24.93±9.89%, P<0.001). No significant differences in ADP-induced platelet aggregation rates were observed between the 2 groups (16.17±9.74% vs. 16.88±12.69%, P>0.05). Among those with bleeding events and among controls, 70% and 80% had an ACA-induced platelet aggregation rate of 0–18% and 18–50%, respectively. Mutation rates of rs6065 in GP1BA and rs1695, rs4891, and rs8191439 in GSTP1 also differed significantly between the 2 groups. Conclusions Lower ACA-induced platelet aggregation rates are associated with increased risk of bleeding in patients with ACS who are on aspirin and ticagrelor. An ACA-induced platelet aggregation rate of 18% may be considered the cutoff point for identifying high risk of aspirin-associated bleeding events in patients with ACS. SNP genotyping may also help predict the risk of bleeding in patients with ACS.

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Section: Discussionmentioning

confidence: 99%

Lower Platelet Aggregation Is a Risk Factor for Dual Antiplatelet Therapy-Associated Bleeding: A Preliminary Retrospective Study with Genotype Analysis

et al. 2020

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“…Popliteal artery puncture both facilitates the manipulation in this region, where the retrograde approach is technically challenging, and minimizes the before mentioned complications of contralateral femoral puncture. Also, it protects the patient from CIN thanks to low radiopaque contrast use as it is closer to the lesion [21][22][23]. Restenosis occurs in 40 to 60 percent of treated segments after one year [24,25].…”

Section: Discussionmentioning

confidence: 99%

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2019

Eu Clin Anal Med

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Aim: In recent years endovascular treatment of symptomatic peripheral arterial disease (PAD) provides many advantages like fast application, fast recovery and low cost in many cases. And it is recommended as a primary revascularization strategy in a wide range of many PAD patients rather than surgical treatment of symptomatic peripheral arterial disease (PAD). However optimal methods of catheter-based treatment for renal insufiency patients remain controversial. Material and Methods: In Yeditepe University Faculty of Medicine Hospital between 2017-2018, we performed endovascular treatment with ipsilateral popliteal artery puncture of 18 patients. Pre-op creatinin , EGFR and post-operative creatinin levels and puncture area complications were compared. Results: Primary end-point was technical success with popliteal access without any post-operative complications and low dosage contrast usage. Secondary end-point was 3 months follow-up stenosis degree. No punction area complications were notted. None of patients had any hematoma, ecchymosis or pseudoaneurisyms in puncture area. And after procedure none of patients had to have dialisysis treatment despite high level of kreatinin and low EGFR values. In third month control follow-up patients were asymptomatic and no recurren vascular disease was seen in doppler usg. Discussion: As a conclusion, balloon angioplasty performed with ipsilateral popliteal artery micro-puncture with manually low dosage opaque use, allows the shortest way to access the target lesion and it protects the kidney from opaque toxication with minimizing the amount of opaque usage for superficial femoral artery lesions. Therefore, renal protection was ensured before and after the operation without dialysis in diabetic patients with low EGFR and borderline high creatinine levels in the study group. Furthermore, the incidence of complications is lower with popliteal artery micro-puncture than femoral artery puncture.

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“…Several studies showed that cigarette smoking has a positive correlation with aspirin resistance in different clinical settings [28]. However, another studies showed no correlation [33][34][35]. This variability in findings may be related to sample size, the type of studied population, and the presence of other factors.…”

Section: Analysis Of Risk Variables For Aspirin Resistance Using Bina...mentioning

confidence: 99%

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2023

J. Med. Chem. Sci.

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Background: Transmembrane multiligand receptor RAGE is a protein found on the surface of cells that binds to the advanced glycation end products. Platelet cyclooxygenase activity is elevated in response to RAGE activation, contributing to the formation of a thrombus. Objectives: To examine the connection between RAGE gene rs80096349(C>T), rs1035798(C>T), and rs184003(G>T) polymorphisms and resistance to aspirin in CAD patients from Iraq. Patients and methods: Patients with coronary artery disease (CAD) (161 males and 64 females) were enrolled in the trial between February 2021 and October 2021. All participants were taking prophylactic Aspirin (100 mg). The control group consisted of 130 individuals, including 97 males and 33 females, who appeared to be in good health and were not taking aspirin. Serum thromboxane B2 levels were used to assess the effectiveness of aspirin (TBX2). Patients were classified as either aspirin sensitive or resistant. The polymorphism of RAGE's most closely related single nucleotide polymorphisms (SNPs) was identified using polymerase chain reaction for amplification of the extracted deoxyribonucleic acid and Sanger's method of sequencing. Results: A total of 225 cardiovascular patients compatible with inclusion criteria were enrolled. There were 161(71.6%) male and 64(28.4%) female patients with a mean age of 56.85±8.11years old. The statistical analysis revealed 17.8% (n = 40) aspirin-resistant cases in the study population. Genotypic analysis of our data showed that participants with the T allele of rs184003(G/T) had an increased prevalence in the aspirin-resistant group compared with the aspirin-sensitive group (p<0.05). In contrast, for rs10835798, the frequency was dramatically higher for T alleles in aspirin sensitive group contrasted with the resistant group (p<0.05). The aspirinresistant group was found to have significantly greater RAGE levels than the sensitive group. Conclusion: Our results provide evidence that RAGE expression and gene rs1035798(C>T), and rs184003(G>T) polymorphisms could be predictors for CAD patients' resistance to aspirin.

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Frequency of development of aspirin resistance in the early postoperative period and inadequate inhibition of thromboxane A2 production after coronary artery bypass surgery

Cited by 3 publications

References 24 publications

Lower Platelet Aggregation Is a Risk Factor for Dual Antiplatelet Therapy-Associated Bleeding: A Preliminary Retrospective Study with Genotype Analysis

Lower Platelet Aggregation Is a Risk Factor for Dual Antiplatelet Therapy-Associated Bleeding: A Preliminary Retrospective Study with Genotype Analysis

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