Frequency of diabetes in family members of probands with non‐insulin‐dependent diabetes mellitus

Simmons, David; Gatland, B.; Leakehe, L.; Fleming, Carole

doi:10.1111/j.1365-2796.1995.tb01181.x

Cited by 36 publications

(19 citation statements)

References 28 publications

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“…Remarkably, Simmons et al [19] reported that the maternal predominance was particularly pronounced in the family history of those NIDDM patients who had GD before the onset of NIDDM. Moreover, a maternal excess transmission was also observed on the maternal-grandmaternal side of patients with NIDDM [20].…”

Section: Discussionmentioning

confidence: 99%

Maternal and Paternal Family History of Diabetes in Women with Gestational Diabetes or Insulin-Dependent Diabetes mellitus Type I

Harder

Franke²,

Kohlhoff³

et al. 2001

Gynecol Obstet Invest

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Animal studies have shown that prenatal exposure to a diabetic intrauterine milieu leads to an increased risk in the female offspring of developing gestational diabetes (GD). In the present study, the family history of non-insulin-dependent diabetes mellitus type II (NIDDM) and insulin-dependent diabetes mellitus type I (IDDM) was evaluated in 106 women with GD, as compared to 189 women with IDDM. In GD patients, the prevalence of diabetes was significantly greater in mothers than in fathers (p = 0.03). This was mainly due to a greater prevalence of NIDDM in the mothers (p = 0.05). Furthermore, a significant aggregation of NIDDM was also observed in the maternal-grandmaternal line of GD women, as compared to the paternal-grandpaternal side (p = 0.02). In patients with IDDM no significant difference concerning the prevalence of any type of diabetes between mothers and fathers was observed. In conclusion, an aggregation of NIDDM in mothers and grandmothers of women with GD is reported here. A history of NIDDM on the maternal side of pregnant women should be considered as a particular risk factor for GD and, hence, for intergenerative transmission of NIDDM, which therefore might be prevented, at least in part, by strict avoidance of GD.

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Section: Discussionmentioning

confidence: 99%

Maternal and Paternal Family History of Diabetes in Women with Gestational Diabetes or Insulin-Dependent Diabetes mellitus Type I

Harder

Franke²,

Kohlhoff³

et al. 2001

Gynecol Obstet Invest

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“…Gestational diabetes mellitus (GDM) and type 2 diabetes have common pathophysiologies, including beta cell dysfunction and insulin resistance. Therefore it is reasonable to assume GDM is also heritable, although direct studies are rare (but see Jaworski et al 1989;Kaprio et al 1992;Simmons et al 1995). Also, genetic variation implicated in liability to Type 2 diabetes has also been implicated in liability to GDM (Shaat et al 2005;Shehadeh et al 2005).…”

Section: Gestational Diabetesmentioning

confidence: 97%

Genetic liability to schizophrenia in Oceanic Palau: a search in the affected and maternal generation

et al. 2007

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While liability to schizophrenia (Scz) is due to genetic and environmental factors, specific factors are largely unknown. We postulate a two-hit model for Scz, in which initial liability is generated during fetal brain development: this "hit" is precipitated by environmental stressors biologically interacting with maternal genetic vulnerability to the stress. Additional liability to Scz is generated by individual genetic vulnerability. To evaluate these putative levels of vulnerability, we search in the genome of both affected individuals and their mothers for variation that differs, statistically, from that in the general population. For parental analyses, mothers were treated as "affected," rather than their offspring, and the fathers were treated as "controls". We used a sample from the Palauan population: 175 individuals diagnosed with Scz, broadly defined; 87 mothers and 45 fathers of affected individuals. Pedigree and diagnostic data were available on 2,953 living and deceased subjects. DNA from 553 individuals was genotyped for short tandem repeats (STR) spaced approximately every 10 cM across the genome. We tested for association between affection status and STR alleles; such an approach was reasonable, despite the widely spaced markers, because this population has far-ranging linkage disequilibrium (LD). Results for the truly affected individuals were modest, whereas results from the maternal generation were promising. For a recessive model and a test for excess allele matching across mothers, significant findings occurred for D20S481, D10S1221, D6S1021, D13S317, and D18S976. Regions in which at least two adjacent markers produced substantial association statistics include 2p12-11.2, 2q24.1-32.1, 6q12-14.1, 10q23.2-24.21, 12q23.2-24.21 and 17q23.2-23.3.

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“…www.bjournal.com.br groups (4,(13)(14)(15). Even in the absence of DM during pregnancy, maternal history of DM could be associated with disturbances in carbohydrate metabolism compatible with the presence of insulin resistance in offspring (2,4,6,16).…”

Section: Introductionmentioning

confidence: 99%

“…Even in the absence of DM during pregnancy, maternal history of DM could be associated with disturbances in carbohydrate metabolism compatible with the presence of insulin resistance in offspring (2,4,6,16). Since insulin resistance is also considered to be a risk factor for diabetic micro-and macrovascular complications (17,18), patients with type 2 DM and positive maternal history of DM could be at higher risk of presenting chronic complications of diabetes.…”

Section: Introductionmentioning

confidence: 99%

The prevalence of chronic diabetic complications and metabolic syndrome is not associated with maternal type 2 diabetes

Scheffel

Kramer

Rados

et al. 2008

Braz J Med Biol Res

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The maternal history of type 2 diabetes mellitus (DM) has been reported more frequently in patients with type 2 DM than paternal history. The aim of the present study was to determine if there was an association between maternal history of DM and the presence of chronic complications or metabolic syndrome (MetS) in patients with type 2 DM. A cross-sectional study was conducted with 1455 patients with type 2 DM. All outpatients with type 2 diabetes attending the endocrine clinics who fulfilled the eligibility criteria were included. Familial history of DM was determined with a questionnaire. Diabetic complications were assessed using standard procedures. The definition of MetS used was that of the World Health Organization and the National Cholesterol Education Program's Adult Treatment Panel III report criteria. Maternal history of DM was present in 469 (32.3%), absent in 713 (49.1%) and unknown in 273 patients (18.7%). Paternal history of DM was positive in 255 (17.6%), negative in 927 (63.8%) and unknown in 235 patients (16.1%). The frequency of microvascular chronic complications in patients with and without a positive maternal history of DM was similar: diabetic nephropathy (51.5 vs 52.5%), diabetic retinopathy (46.0 vs 41.7%), and diabetic sensory neuropathy (31.0 vs 37.1%). The prevalence of macrovascular chronic complications and MetS was also similar. Patients with type 2 DM were more likely to have a maternal than a paternal history of DM, although maternal history of DM was not associated with an increased prevalence of chronic complications or MetS.

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Frequency of diabetes in family members of probands with non‐insulin‐dependent diabetes mellitus

Abstract: The mother is a more important conduit for inheritance of diabetes than the father in these three ethnic groups. A history of diabetes in pregnancy confers an extra risk to the offspring above this usual maternal excess.

Cited by 36 publications

References 28 publications

Maternal and Paternal Family History of Diabetes in Women with Gestational Diabetes or Insulin-Dependent Diabetes mellitus Type I

Maternal and Paternal Family History of Diabetes in Women with Gestational Diabetes or Insulin-Dependent Diabetes mellitus Type I

Genetic liability to schizophrenia in Oceanic Palau: a search in the affected and maternal generation

The prevalence of chronic diabetic complications and metabolic syndrome is not associated with maternal type 2 diabetes

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