Frequency of EEG abnormalities in age-matched siblings of autistic children with abnormal sleep EEG patterns

Chez, Michael G.; Buchanan, Thomas M.; Aimonovitch, Mary; Mrazek, Susan; Krasne, Valerie; Langburt, Wayne; Memon, Shoaib Ahmed

doi:10.1016/j.yebeh.2003.11.019

Cited by 24 publications

(9 citation statements)

References 30 publications

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“…However whether the trajectories are normative may be answered in what lies beyond the points of convergence, which will be determined by future studies that extend beyond 24 months. Many studies have documented that brain activity in siblings of individuals with ASD is different from that of the affected individual [38], [56], while there is also evidence that brain structure and function in siblings is still different from typically developing individuals [57]. Thus, reconciling whether there is normalization between high risk and typically developing infants or further differentiation along these trajectories will require further study of at risk children.…”

Section: Discussionmentioning

confidence: 99%

Developmental Trajectories of Resting EEG Power: An Endophenotype of Autism Spectrum Disorder

et al. 2012

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Current research suggests that autism spectrum disorder (ASD) is characterized by asynchronous neural oscillations. However, it is unclear whether changes in neural oscillations represent an index of the disorder or are shared more broadly among both affected and unaffected family members. Additionally, it remains unclear how early these differences emerge in development and whether they remain constant or change over time. In this study we examined developmental trajectories in spectral power in infants at high- or low-risk for ASD. Spectral power was extracted from resting EEG recorded over frontal regions of the scalp when infants were 6, 9, 12, 18 and 24 months of age. We used multilevel modeling to assess change over time between risk groups in the delta, theta, low alpha, high alpha, beta, and gamma frequency bands. The results indicated that across all bands, spectral power was lower in high-risk infants as compared to low-risk infants at 6-months of age. Furthermore high-risk infants showed different trajectories of change in spectral power in the subsequent developmental window indicating that not only are the patterns of change different, but that group differences are dynamic within the first two years of life. These findings remained the same after removing data from a subset of participants who displayed ASD related behaviors at 24 or 36 months. These differences in the nature of the trajectories of EEG power represent important endophenotypes of ASD.

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Section: Discussionmentioning

confidence: 99%

Developmental Trajectories of Resting EEG Power: An Endophenotype of Autism Spectrum Disorder

et al. 2012

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“…It has been reported that they have abnormal sleep patterns and sleep disorders [11,49], such as requiring certain duration of sleep time (time required for deep sleep) [50], sleep disturbance threshold when almost asleep [51], low quailties of sleep [52], waking up at midnight or too early [53] and abnormal sleep routine [54].…”

Section: Sleep Disorder Of Autistic Childrenmentioning

confidence: 99%

“…Approximately 43% -68% of autistic children experienced sleep epilepsy [52]. This high percentage may be due to genetic factors.…”

Section: Sleep Disorder Of Autistic Childrenmentioning

confidence: 99%

Addressing sleep disorder of autistic children with Qur’anic sound therapy

Tumiran¹,

Mohamad²,

Saat³

et al. 2013

Health

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Autism is a neural development disorder characterized by the deterioration in social interacttion, abnormal language expression, repetitive actions, imaginative game tendencies, and limited and/or obsessiveness in certain activities/ interests. Lack of sleep is one of the factors contributing to the worsening of overall negative symptoms of autistic children. From the Islamic perspective, sleep is a necessity and could function as a treatment for health problems, in addition to influencing behavior patterns. Sound therapy has been used in dealing with various health problems, including sleep problems and mental ill health. Possibly, it can also address sleep problems of the autistic children. Listening to the melodious Qur'anic recitation is known to have therapeutic effects even on individuals who do not understand the meaning of the verses being read; it could function as sound therapy. However, no established work has been done to study the effect of Qur'anic verses recitation on autistic children and their sleep problems. Similar to the use of music therapy, Qur'anic recitation is also expected to have a positive impact on speech, learning and interpersonal relationship. As a healing medium, Qur'anic therapy is also expected to have a better result as compared to other conventional sound therapy since its content could be psychotherapeutic.

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“…A rather interesting study was conducted by Chez et al (2004) where they examined the rate of EEG abnormalities of age-matched siblings of autistic children who had abnormal sleep EEGs. They report less abnormalities in these children and conclude that genetic factors alone do not explain the higher frequency of EEG abnormalities reported in ASDs.…”

Section: Eeg Abnormalities In Asdmentioning

confidence: 99%

Standard EEG: A Research Roadmap for Neuropsychiatry

Boutros¹

2013

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Frequency of EEG abnormalities in age-matched siblings of autistic children with abnormal sleep EEG patterns

Cited by 24 publications

References 30 publications

Developmental Trajectories of Resting EEG Power: An Endophenotype of Autism Spectrum Disorder

Developmental Trajectories of Resting EEG Power: An Endophenotype of Autism Spectrum Disorder

Addressing sleep disorder of autistic children with Qur’anic sound therapy

Standard EEG: A Research Roadmap for Neuropsychiatry

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