Frequency of etiological factors among patients with acquired premature ejaculation: prospective, observational, single-center study

Çulha, Mehmet Gökhan; Tüken, Murat; Gönültaş, Serkan; Çakır, Ömer; Şerefoğlu, Ege Can

doi:10.1038/s41443-019-0188-x

Cited by 39 publications

(29 citation statements)

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“…Our previous investigation on outpatients in the Department of Andrology found that many patients with erectile dysfunction, premature ejaculation and other diseases had anxiety and depression 26 . Besides, within many previous studies that investigated possible influencing factors for ED or PE, there're plenty of studies reported the relationship between "depression / anxiety and changes of sexual function", which have similar conclusion as the current study [27][28][29][30][31] . The significance of the results of our study is that during a pandemic disease, even with low mortality rate, decline in sexuality was associated with depression and anxiety by the disease, and worse life satisfaction and quality.…”

Section: Discussionsupporting

confidence: 83%

“…Altogether, 612 questionnaires were collected, and 251 (41.0%) respondents completed the second part of the questionnaire. The median age for all subjects was 28 years old (interquartile IQR [24][25][26][27][28][29][30][31][32][33][34][35]. A total of 322 (52.6%) subjects were unmarried, 280 (45.8%) were married and 10 (1.6%) were divorced or widowed.…”

Section: Baseline Characteristicsmentioning

confidence: 99%

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An Online Questionnaire Survey on the Sexual Life and Sexual Function of Chinese Adult Men During the Coronavirus Disease 2019 Epidemic

et al. 2020

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Introduction There has been no report regarding the impact on male sexual life or sexual function by changes in lifestyle during the coronavirus disease 2019 (COVID-19) epidemic. Aim To investigate the changes in sexual life and sexual function of Chinese men during the COVID-19 epidemic. Methods An online questionnaire was created and the survey was administered through social media to Chinese adult men. Main Outcome Measure The main end point was the deteriorated erectile function or ejaculatory control ability, defined by self-evaluation or by decreased International Index of Erectile Function-5 items (IIEF-5) scores or increased premature ejaculation diagnostic tool (PEDT) scores. Results Altogether, 612 questionnaires were collected. About 322 (52.6%) subjects were unmarried. About 8.4% and 8.5% subjects reported deteriorated erectile function or ejaculation control ability by self-evaluation, whereas 31.9% and 17.9% subjects showed decreased IIEF-5 scores or increased PEDT scores. Subjects with deteriorated erectile function by self-evaluation and decreased IIEF-5 scores had higher General Anxiety Disorder-7 (P < .001 and P = .001) and higher Patient Health Questionnaire-9 score (P < .001 and P = .002) after the epidemic, decreased frequency of sexual life (P < .001 and P < .001) and physical exercise (P = .009 and .007) after the epidemic. Subjects with deteriorated ejaculation control ability by self-evaluation and increased PEDT scores had higher General Anxiety Disorder-7 (P < .001 and P < .001) and higher Patient Health Questionnaire-9 score (P < .001 and P = .002) after the epidemic. Subjects with decreased frequency of sexual life had reduced income (P < .001), increased anxiety (P < .001) and depression (P < .001). Married subjects had higher proportion of improved depression (P = .048) and increased frequency of sexual life (P = .010). Conclusion During the COVID-19 epidemic, decreased sexual function was present in a certain proportion of adult men, and the risk factors include increased anxiety and depression, and decreased frequency of sexual life.

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Section: Discussionsupporting

confidence: 83%

Section: Baseline Characteristicsmentioning

confidence: 99%

An Online Questionnaire Survey on the Sexual Life and Sexual Function of Chinese Adult Men During the Coronavirus Disease 2019 Epidemic

et al. 2020

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“…Although the first data on PE were available more than 100 years ago, its pathophysiology has not yet been completely understood (Culha, Tuken, Gonultas, Cakir, & Serefoglu, 2020;Wiener, 1895).…”

Section: Introductionmentioning

confidence: 99%

“…Pre‐mature ejaculation (PE), especially among younger people, is one of the most frequent sexual dysfunctions (Jannini & Lenzi, 2005). Although the first data on PE were available more than 100 years ago, its pathophysiology has not yet been completely understood (Culha, Tuken, Gonultas, Cakir, & Serefoglu, 2020; Wiener, 1895). In the literature, there is no certain prevalence of PE but it was reported 20% and 25.8% of the male population are suffering from PE, 2.3% and 3% for lifelong PE, and 3.9% and 4.8% for acquired PE of the general population in Turkey and China respectively (Gao et al., 2013; Serefoglu et al., 2011).…”

Section: Introductionmentioning

confidence: 99%

Can low serum brain‐derived neurotrophic factor levels be associated with lifelong premature ejaculation?; A pilot study

et al. 2020

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This study aimed to present the association between the serum level of brain-derived neurotrophic factor (BDNF) and the lifelong premature ejaculation (PE). The data of 40 patients with lifelong PE and 40 healthy controls were evaluated prospectively. PE diagnostic tool and patient-reported outcome measures were performed to the participants. The serum BDNF level measurement was made after the collecting of blood samples in both groups. The mean ± SD age of the PE and control group was 34.43 ± 5.71 and 33.03 ± 3.97 years respectively (p = .228). Only the participant who has been married included in the study, and there was no difference in the mean marriage duration. In both groups, smoking status, alcohol use and body mass index were similar. The median PE diagnostic tool scores were 15 (11-20), and serum BDNF levels were 225.3 (26.1-689.6) ng/ml in the PE group, 5 (0-9) and 540.9 (102.9-769.2) ng/ ml in the control group respectively (p < .001 for both). The patients with PE had significantly lower serum BDNF levels. Our study suggests that lower serum BDNF levels may be directly related to lifelong PE.

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“…Premature ejaculation (PE) is the most frequently encountered sexual disorder in urology practice, with a prevalence rate above 20% among men (Culha, Tuken, Gonultas, Cakir, & Serefoglu, 2020;Jannini & Lenzi, 2005). Animal studies have revealed the role of serotonergic and dopaminergic neurotransmission, as well as the genetic factors, in pathophysiology of LPE (Ågmo & Picker, 1990;Ferrari & Giuliani, 1994;Santtila et al, 2010;Waldinger, 2016).…”

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confidence: 99%

The effect of plasma melatonin levels in the treatment of lifelong premature ejaculation with selective serotonin reuptake inhibitors

et al. 2020

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The aim of our study was to compare melatonin levels of patients with lifelong premature ejaculation (LPE) (n:60) with healthy controls (n:30) and to investigate the changes of melatonin levels in the treatment with dapoxetine and sertraline. Age, body mass index, duration of marriage, weekly intercourse number, International Index of Erectile Function scores, Intravaginal Ejaculation Latency Time (IELT) and melatonin levels were recorded. LPE patients were divided into two treatment groups. The first group was included 30 patients, who received 60 mg dapoxetine for six weeks, twice a week, an hour before intercourse. The second group received 50 mg of sertraline daily, for six weeks. IELT and melatonin measures were repeated after the treatment. IELT (dapoxetine group: 41.22 ± 21.3 s, sertraline group: 48 ± 23.11 s, control group: 195.54 ± 84.14 s; p < .001) and melatonin levels (dapoxetine group: 5.75 ± 2.04 pg/mL, sertraline group: 5.49 ± 2.88 pg/mL, control group: 13.4 ± 12.09 pg/mL; p < .001) of both LPE groups were significantly lower than control group. Following the six‐week sertraline (before: 48 ± 23.11 s, after: 101.01 ± 59.55 s; p < .001) and dapoxetine (before: 41.22 ± 21.3 s, after: 97.39 ± 44.1 s; p < .001) treatments, IELT increased. The melatonin levels increased in the sertraline group (before: 5.49 ± 2.88 pg/mL, after: 10.6 ± 7.37 pg/mL; p < .001). Our results indicate that melatonin levels of LPE patients are lower than levels of healthy volunteers. Furthermore, we found a significant increase in melatonin levels following sertraline treatment.

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Frequency of etiological factors among patients with acquired premature ejaculation: prospective, observational, single-center study

Cited by 39 publications

References 50 publications

An Online Questionnaire Survey on the Sexual Life and Sexual Function of Chinese Adult Men During the Coronavirus Disease 2019 Epidemic

An Online Questionnaire Survey on the Sexual Life and Sexual Function of Chinese Adult Men During the Coronavirus Disease 2019 Epidemic

Can low serum brain‐derived neurotrophic factor levels be associated with lifelong premature ejaculation?; A pilot study

The effect of plasma melatonin levels in the treatment of lifelong premature ejaculation with selective serotonin reuptake inhibitors

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