Frequency of functional gastrointestinal disorders in children with familial Mediterranean fever

Ekinci, Rabia Miray Kışla; Balcı, Sibel; Akay, Eray; Tümgör, Gökhan; Doğruel, Dilek; Altıntaş, Derya Ufuk; Yılmaz, Mustafa

doi:10.1007/s10067-019-04452-1

Cited by 10 publications

(10 citation statements)

References 24 publications

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“…Five papers reported specifically on the number of children under four years with more than one FGID, with 0.4–4.5% having two FGID, [ 12 , 18 , 22 ] and 0.1–0.6% having more than two or multiple FGID [ 22 , 27 ]. Among children over four years, 4% had multiple FGID [ 14 ].…”

Section: Resultsmentioning

confidence: 99%

“…The category of IBS was classified with the sub-types of IBS with constipation, IBS with diarrhoea, IBS with constipation and diarrhoea (mixed type), and unspecified IBS. Five papers divided their IBS sub-types, with the main finding being that up to 8.8% more experience constipation-predominant IBS than diarrhoea-predominant IBS [ 14 , 15 , 20 , 25 , 26 ].…”

Section: Resultsmentioning

confidence: 99%

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Systematic Review of Pediatric Functional Gastrointestinal Disorders (Rome IV Criteria)

Vernon‐Roberts

Alexander

Day

2021

JCM

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Functional gastrointestinal disorders (FGID) are common among children and may cause a significant symptom burden. The Rome criteria are symptom-based guidelines for the assessment of FGID among children and adults. The aim of this systematic review was to estimate the prevalence of FGID utilizing the revised Rome IV criteria. Nine health databases were searched. The inclusion criteria were: prospective FGID prevalence data using the Rome IV criteria for children up to 18 years, and the exclusion criteria were: cohorts with known gastrointestinal or organic conditions. The data were presented as a percentage of children experiencing at least one FGID, as well as in individual categories. The searches identified 376 papers, with 20 included in the final analysis, providing a pooled cohort of 18,935 children. The median prevalence of FGID for children aged up to four years was 22.2% (range 5.8–40%), and aged four–eighteen years was 21.8% (range 19–40%). The most common FGID for children aged 0–12 months was infant regurgitation, the most common FGID for those aged 13–48 months were functional constipation and cyclic vomiting, and, for those aged over four years, functional constipation, functional dyspepsia, and irritable bowel syndrome. This reported overall incidence of FGID may be used as a benchmark of normative data among the general population and comparative data for those with comorbid disease.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Systematic Review of Pediatric Functional Gastrointestinal Disorders (Rome IV Criteria)

Vernon‐Roberts

Alexander

Day

2021

JCM

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“…For this reason, abdominal pain (with or without peritonitis) appears in all clinical FMF criteria [55,56] as well as in the more recent Eurofever classification criteria [21]. Although less useful for diagnostic purposes, other gastrointestinal manifestations have been often reported in FMF patients [195]. Noteworthy, inflammatory bowel diseases seem to be more frequent and severe in patients with FMF [196] and, conversely, the rate of MEFV mutations has been found higher in subjects diagnosed with inflammatory bowel diseases [197].…”

Section: Gastrointestinal Manifestationsmentioning

confidence: 99%

Hints for Genetic and Clinical Differentiation of Adult-Onset Monogenic Autoinflammatory Diseases

Gaggiano

Rigante

Vitale

et al. 2019

Mediators of Inflammation

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Monogenic autoinflammatory diseases (mAIDs) are inherited errors of innate immunity characterized by systemic inflammation recurring with variable frequency and involving the skin, serosal membranes, synovial membranes, joints, the gastrointestinal tube, and/or the central nervous system, with reactive amyloidosis as a potential severe long-term consequence. Although individually uncommon, all mAIDs set up an emerging chapter of internal medicine: recent findings have modified our knowledge regarding mAID pathophysiology and clarified that protean inflammatory symptoms can be variably associated with periodic fevers, depicting multiple specific conditions which usually start in childhood, such as familial Mediterranean fever, tumor necrosis factor receptor-associated periodic syndrome, cryopyrin-associated periodic syndrome, and mevalonate kinase deficiency. There are no evidence-based studies to establish which potential genotype analysis is the most appropriate in adult patients with clinical phenotypes suggestive of mAIDs. This review discusses genetic and clinical hints for an ideal diagnostic approach to mAIDs in adult patients, as their early identification is essential to prompt effective treatment and improve quality of life, and also highlights the most recent developments in the diagnostic work-up for the most frequent hereditary periodic febrile syndromes worldwide.

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“…Functional gastrointestinal disorders are more frequent in children with FMF, and between those, functional dyspepsia and irritable bowel syndrome are more frequent [6].…”

Section: Clinical Presentation Of Fmfmentioning

confidence: 98%

FMF is not always “fever”: from clinical presentation to “treat to target”

Maggio

Corsello

2020

Ital J Pediatr

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Familial Mediterranean Fever, a monogenic autoinflammatory disease secondary to MEFV gene mutations in the chromosome 16p13, is characterized by recurrent self-limiting attacks of fever, arthritis, aphthous changes in lips and/or oral mucosa, erythema, serositis. It is caused by dysregulation of the inflammasome, a complex intracellular multiprotein structure, commanding the overproduction of interleukin 1. Familial Mediterranean Fever can be associated with other multifactorial autoinflammatory diseases, as vasculitis and Behçet disease. Symptoms frequently start before 20 years of age and are characterized by a more severe phenotype in patients who begin earlier. Attacks consist of fever, serositis, arthritis and high levels of inflammatory reactants: C-reactive protein, erythrocyte sedimentation rate, serum amyloid A associated with leucocytosis and neutrophilia. The symptom-free intervals are of different length. The attacks of Familial Mediterranean Fever can have a trigger, as infections, stress, menses, exposure to cold, fatrich food, drugs. The diagnosis needs a clinical definition of the disease and a genetic confirmation. An accurate differential diagnosis is mandatory to exclude infective agents, autoimmune diseases, etc. In many patients there is no genetic confirmation of the disease; furthermore, some subjects with the relieve of MEFV mutations, show a phenotype not in line with the diagnosis of Familial Mediterranean Fever. For these reasons, diagnostic criteria were developed, as Tel Hashomer Hospital criteria, the "Turkish FMF Paediatric criteria", the "clinical classification criteria for autoinflammatory periodic fevers" formulated by PRINTO. The goals of the treatment are: prevention of attacks recurrence, normalization of inflammatory markers, control of subclinical inflammation in attacks-free intervals and prevention of medium and long-term complications, as amyloidosis. Colchicine is the first step in the treatment; biological drugs are effective in non-responder patients. The goal of this paper is to give a wide and broad review to general paediatricians on Familial Mediterranean Fever, with the relative diagnostic, clinical and therapeutic aspects.

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Frequency of functional gastrointestinal disorders in children with familial Mediterranean fever

Cited by 10 publications

References 24 publications

Systematic Review of Pediatric Functional Gastrointestinal Disorders (Rome IV Criteria)

Systematic Review of Pediatric Functional Gastrointestinal Disorders (Rome IV Criteria)

Hints for Genetic and Clinical Differentiation of Adult-Onset Monogenic Autoinflammatory Diseases

FMF is not always “fever”: from clinical presentation to “treat to target”

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