Frequency of haemoglobinopathies and glucose-6-phosphate dehydrogenase deficiency in Basra

Hassan, Abdul Kareem F.; Taha, J Y; Al-Naama, Lamia M.; Widad, N M; Jasim, Saja Nasief

doi:10.26719/2003.9.1-2.45

Cited by 40 publications

(11 citation statements)

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“…Nearly similar results were reported by Sawsan S. Abbas (24), NelsonDA (25), and ErbagclAB. (26) Reticulocyte count generally was high, precisely the RPI (Reticulocyte Production Index), which was between 2-3 in most of the involved cases; this indicates that hemolysis exceeded the ability of bone marrow to compensate, so the true reticulocyte count may be low for the first 3-4 days and this consistent with Hassan MK (27) and ErbagclAB. (26)…”

Section: Discussionmentioning

confidence: 52%

Glucose-6 Phosphate Dehydrogenase Deficiency in terms of hemolysis indicators and management

Al-Momen¹,

Athab²,

Al-Zubaidi³

2017

JFacMedBagdad

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Background: Glucose-6 Phosphate Dehydrogenase (G6PD) Deficiency is one of the commonest inherited enzyme abnormalities in humans, caused by many mutations that reduce the stability of the enzyme and its level as red cells progress in age.Objectives: To determine the useful hematologic indicators of hemolysis, observe an early detection of G6PD enzyme deficiency (if any), and the available therapeutic measures.Patients and Methods: 123 patients with G6PD deficiency and hemolysis after exposure to fava beans whom visited AL-Elwiya Pediatric Teaching Hospital from the 1st of February 2016 till 31st of May 2016 were entered this study retrospectively. Hemolysis laboratory indicators were observed. Management supportive measures were put in consideration also.Results: We found that 10-20% levels of hematocrit and normochromic normocytic anemia were the most frequent on presentation, while a range of 15.1-20% of reticulocyte counts was the most common with lower rates in females group. Hyperbilirubinemia was seen with nil patients had abnormal renal function tests. About three quarters (76.4%) of the total number of involved cases had glucose-6-phosphate dehydrogenase (G6PD) deficiency.Only 4 patients required no blood transfusion, 102 patients (82.9%) needed transfusion once, and the rest 17 (13.8%) had more than one blood transfusion. Most of cases (91.1%) recovered within the first 3 days. However; all cases were recovered by the fourth day of admission.Conclusion: Hemoglobin and blood morphology with hyperbilirubinemia were useful hematologic indicators of hemolytic process, while blood transfusion was the most used therapeutic measure, and recovery was expected within 2-3 days.

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Section: Discussionmentioning

confidence: 52%

Glucose-6 Phosphate Dehydrogenase Deficiency in terms of hemolysis indicators and management

Al-Momen¹,

Athab²,

Al-Zubaidi³

2017

JFacMedBagdad

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“…The majority of the cases were G6PD deficiency (6.7% of neonates examined), which is common in many Eastern Mediterranean nations, including Iraq (25)(26)(27). The incidence of G6PD deficiency in central and southern Iraq has been the subject of some investigations (28)(29)(30). Due to the COVID-19 outbreak, there were more infants examined in 2021 than there were in 2019 and 2020.…”

Section: Discussionmentioning

confidence: 99%

Overview of Duhok/Iraq Project of Expanded Newborn Screening

Jameel¹,

Mehe²

2024

Mil. Med. Sci. Lett.

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Background: Newborn screening is a public health prevention system that intends to detect, early in life, a group of serious diseases that require early intervention. Institutionalizing and sustaining this system presents a remarkable challenge in developing public health systems. Duhok project for expanded newborn screening started in June 2018 with a panel of seven diseases including phenylketonuria (PKU), Galactosemia (GAL), congenital hypothyroidism (CHT), Cystic fibrosifcardiacs (CF), Congenital adrenal hyperplasia (CAH), G6PD deficiency and biotinidase deficiency. In the next few years, the panel expanded to include, finally, 72 tests, to detect various disorders of amino acids, fatty acid oxidation, organic acid, lysosomal storage disease, immunodeficiency, spinal muscular dystrophy, and others. Objectives: To evaluate the Duhok project of expanded newborn screening. Methods: In a retrospective cross-sectional study conducted between June 2018 and 31 November 2021, a total of 3872 newborns were screened from 8 governorates of Iraq and the Kurdistan region. Heel prick dry blood spot samples were obtained from all newborns for biochemical and immunoassay testing. Results: A total of 527 cases were detected, frequently detected disorders were Glucose 6 phosphate dehydrogenase deficiency, cystic fibrosis, congenital adrenal hyperplasia and phenyl ketone urea. Most of the positive cases (66%) were older than 7 days at screening. Conclusion:The article highlights the overview of the expanded newborn screening project in Duhok/Iraq. NBS has not yet become prevalent in Iraq, thus the screening for metabolic disorders is not normally requested until a patient is already experiencing symptoms.

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“…In Iraq thalassemia is a serious and real public health problem due to the unavailability of equipment and drugs during different periods of unrest and war and calls for an effective management plan, including public health education programsto facilitate early diagnosis and treatment [14,15,16] .…”

Section: Discussionmentioning

confidence: 99%

“…This high serum ferritin level most likely due to frequent blood transfusions and hemolysis of red blood cells. Leecharoenkiat et al [12] and Gardenghi et al [14] mentioned iron overload in β-thalassemia major patients as predicted by high serum ferritin level due to frequent blood transfusions, hemolysis of red blood cells, and increased gastrointestinal iron absorption due to paradoxical hepcidin suppression from dyserythropoiesis.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Reproductive Hormones in Patients with ?-Thalassemia Major in Misan Province, Iraq

2020

MLU

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Assessment of serum ferritin, FSH, LH, estradiol, testosterone levels in β-thalassemia major patients. A total 50 (30 male and 20 female) children with β-thalassemia major patients with ages range 11-16 years and 50 age and sex matched healthy adolescents as control group were included in this study. The study subjects divided into 2 more subgroups: 11-13 years, and 14-16 years to measure mean serum ferritin, FSH, LH, testosterone, estradiol hormones. There was significant increase (P <0.05) in serum ferritin level in male and female patients as compared to control groups. Male patients have significant decreased (P<0.05)serum levels of FSH, LH, testosterone and estradiol, while female patients have non-significant (P >0.05) high serum FSH and testosterone levels, but LH, estradiol levels were non-significant (P>0.05) lowas compared to control. In age subgroup 11-13 years, male patients have significant (P<0.05) decreased reproductive hormones levels as compared to control, however in 14 -16 years subgroups serum FSH,LH and estradiol levels in male patients were significantly decreased as compared to control (P<0.05), whereas,hormones levels in female patients didn't show significant differences in comparison to female control in both age subgroups (P>0.05). Serum ferritin had an inverse correlation with serum FSH, LH, testosterone, estradiol hormones levels. Patients with β-thalassemia major have iron overload with inverse correlation between gonadal hormones and serum ferritin.

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Frequency of haemoglobinopathies and glucose-6-phosphate dehydrogenase deficiency in Basra

Cited by 40 publications

References 0 publications

Glucose-6 Phosphate Dehydrogenase Deficiency in terms of hemolysis indicators and management

Glucose-6 Phosphate Dehydrogenase Deficiency in terms of hemolysis indicators and management

Overview of Duhok/Iraq Project of Expanded Newborn Screening

Evaluation of Reproductive Hormones in Patients with ?-Thalassemia Major in Misan Province, Iraq

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